Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Endomembrane Trafficking of Ras

1999 • 753 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1998 • 360 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase

2000 • 340 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi

1999 • 227 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

1993 • 154 citations

Mitogenic and oncogenic properties of the small G protein Rap1b

1998 • 140 citations

Ras-like GTPases

1997 • 132 citations

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

1991 • 128 citations

Human SPA-1 Gene Product Selectively Expressed in Lymphoid Tissues Is a Specific GTPase-activating Protein for Rap1 and Rap2

1997 • 128 citations

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

1999 • 126 citations

Activation of R-Ras by Ras-Guanine Nucleotide-releasing Factor

1997 • 126 citations

[10] Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

1995 • 124 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

1992 • 107 citations

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N)

1997 • 106 citations

Costimulation through CD28 Suppresses T Cell Receptor-dependent Activation of the Ras-like Small GTPase Rap1 in Human T Lymphocytes

1998 • 103 citations

Chapter 24 Postembedding Labeling on Lowicryl K4M Tissue Sections: Detection and Modification of Cellular Components

1989 • 103 citations

Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1

1997 • 100 citations

Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes

1998 • 92 citations

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

1999 • 89 citations

The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

1999 • 84 citations

Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases.

1992 • 78 citations

Identification and Characterization of Potential Effector Molecules of the Ras-related GTPase Rap2

1999 • 76 citations

Identification of a specific effector of the small GTP‐binding protein Rap2

1998 • 63 citations

Activity of Rap1 Is Regulated by Bombesin, Cell Adhesion, and Cell Density in NIH3T3 Fibroblasts

1998 • 63 citations

smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells.

1992 • 63 citations

Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants

1986 • 56 citations

Transformation of rat cells by fusion-infection with Rous sarcoma virus

1980 • 52 citations

In search of a function for the Ras‐like GTPase Rap1

1997 • 45 citations

Monoclonal antibody highly sensitive for the detection of ras p21 in immunoblotting analysis.

1987 • 45 citations

Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21.

1992 • 40 citations

Mechanism of fluoride activation of G protein-gated muscarinic atrial K+ channels.

1991 • 40 citations

Rap1A antagonizes the ability of Ras and Ras-Gap to inhibit muscarinic K+ channels.

1991 • 39 citations

Post-translational processing and subcellular localization of the Ras-related Rap2 protein.

1991 • 35 citations

Effects of the ras‐related rap2 protein on cellular proliferation

1991 • 33 citations

Regulation of the GTPase activity of the ras-related rap2 protein

1992 • 17 citations