Structural design of a eukaryotic DNA repair polymerase: DNA polymerase β

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

Quality Control by DNA Repair

1999 • 1,469 citations

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

1998 • 1,420 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

DNA Replication Fidelity

2000 • 980 citations

The MIDAS display system

1988 • 955 citations

Requirement of mammalian DNA polymerase-β in base-excision repair

1996 • 820 citations

DNA Polymerases: Structural Diversity and Common Mechanisms

1999 • 814 citations

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)

1997 • 779 citations

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

1996 • 775 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

2000 • 700 citations

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.

1994 • 694 citations

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

1998 • 682 citations

Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

1995 • 670 citations

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

1996 • 607 citations

Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism^,

1997 • 601 citations

Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

1994 • 587 citations

The base excision repair pathway

1995 • 536 citations

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

1998 • 520 citations

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

1995 • 485 citations

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

1998 • 474 citations

Crystal Structure of Rat DNA Polymerase β: Evidence for a Common Polymerase Mechanism

1994 • 464 citations

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

1998 • 414 citations

Mammalian Abasic Site Base Excision Repair

1998 • 369 citations

The helix-hairpin-helix DNA-binding motif: a structural basis for non- sequence-specific recognition of DNA

1996 • 362 citations

Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

1997 • 344 citations

Passing the baton in base excision repair.

2000 • 338 citations

Structure of Taq polymerase with DNA at the polymerase active site

1996 • 322 citations

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

1998 • 321 citations

An open and closed case for all polymerases

1999 • 310 citations

Functional sites of interaction between release factor RF1 and the ribosome.

2000 • 297 citations

Mammalian base excision repair and DNA polymerase beta

1998 • 275 citations

Crystal Structures of Human DNA Polymerase β Complexed with DNA: Implications for Catalytic Mechanism, Processivity, and Fidelity^,

1996 • 255 citations

Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis

1996 • 254 citations

Human Thymine DNA Glycosylase Binds to Apurinic Sites in DNA but Is Displaced by Human Apurinic Endonuclease 1

1999 • 251 citations

A plethora of lesion-replicating DNA polymerases

1999 • 244 citations

The Type of DNA Glycosylase Determines the Base Excision Repair Pathway in Mammalian Cells

1999 • 236 citations

Short gap-filling synthesis by DNA polymerase beta is processive

1993 • 228 citations

Different DNA Polymerases Are Involved in the Short- and Long-Patch Base Excision Repair in Mammalian Cells

1998 • 225 citations

Role of DNA Polymerase β in the Excision Step of Long Patch Mammalian Base Excision Repair

1999 • 221 citations

FEN1 Stimulation of DNA Polymerase β Mediates an Excision Step in Mammalian Long Patch Base Excision Repair

2000 • 208 citations

Impairment of Proliferating Cell Nuclear Antigen-dependent Apurinic/Apyrimidinic Site Repair on Linear DNA

1998 • 202 citations

Eukaryotic DNA polymerases in DNA replication and DNA repair

1998 • 193 citations

Human DNA Polymerase β Deoxyribose Phosphate Lyase

1998 • 186 citations

2.3 Å crystal structure of the catalytic domain of DNA polymerase β

1994 • 168 citations

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein

1999 • 166 citations

Evidence for an Imino Intermediate in the DNA Polymerase β Deoxyribose Phosphate Excision Reaction

1996 • 165 citations

Enzyme-DNA Interactions Required for Efficient Nucleotide Incorporation and Discrimination in Human DNA Polymerase β

1996 • 165 citations

Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain.

1990 • 165 citations

Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule”

1997 • 163 citations

Stereochemical studies of the .beta.-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys

1991 • 160 citations

A Structural Basis for Metal Ion Mutagenicity and Nucleotide Selectivity in Human DNA Polymerase β^,

1996 • 158 citations

[11] Purification and domain-mapping of mammalian DNA polymerase β

1995 • 157 citations

Protection against Methylation-induced Cytotoxicity by DNA Polymerase β-Dependent Long Patch Base Excision Repair

2000 • 150 citations

Functional Analysis of the Amino-terminal 8-kDa Domain of DNA Polymerase β as Revealed by Site-directed Mutagenesis

1998 • 138 citations

The Fidelity of DNA Polymerase β during Distributive and Processive DNA Synthesis

1999 • 134 citations

Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group.

1994 • 132 citations

DNA Polymerase β: Structure−Fidelity Relationship from Pre-Steady-State Kinetic Analyses of All Possible Correct and Incorrect Base Pairs for Wild Type and R283A Mutant

1997 • 119 citations

Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli.

1992 • 99 citations

Steady-state kinetics of mouse DNA polymerase .beta.

1979 • 98 citations

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines

1998 • 98 citations

Evidence for a role for DNA polymerase β in mammalian meiosis

1997 • 97 citations

Replication of non-hydrogen bonded bases by DNA polymerases: A mechanism for steric matching

1998 • 97 citations

Structural insights into DNA polymerase β fidelity: hold tight if you want it right

1998 • 88 citations

Strategic down-regulation of DNA polymerase β by antisense RNA sensitizes mammalian cells to specific DNA damaging agents

1995 • 82 citations

Catalytic Center of DNA Polymerase β for Excision of Deoxyribose Phosphate Groups

1998 • 80 citations

Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase β. Correlation with DNA binding and dRP lyase activity 1 1Edited by P. E. Wright

2000 • 77 citations

Characterization of the Metal Ion Binding Helix−Hairpin−Helix Motifs in Human DNA Polymerase β by X-ray Structural Analysis^,

1996 • 75 citations

Thermodynamics of Human DNA Ligase I Trimerization and Association with DNA Polymerase β

1998 • 73 citations

Mapping of the 5′-2-Deoxyribose-5-phosphate Lyase Active Site in DNA Polymerase β by Mass Spectrometry

2000 • 69 citations

Delayed DNA joining at 3' mismatches by human DNA ligases

1999 • 61 citations

Spectroscopic studies of the structural domains of mammalian DNA beta-polymerase.

1991 • 60 citations

The Mutator Form of Polymerase β with Amino Acid Substitution at Tyrosine 265 in the Hinge Region Displays an Increase in both Base Substitution and Frame Shift Errors

1998 • 60 citations

Base Substitution Specificity of DNA Polymerase β Depends on Interactions in the DNA Minor Groove

1999 • 57 citations

DNA polymerases on the move

1998 • 56 citations

Identification of residues in the single-stranded DNA-binding site of the 8-kDa domain of rat DNA polymerase beta by UV cross-linking.

1993 • 50 citations

DNA Polymerase β and DNA Synthesis in Xenopus Oocytes and in a Nuclear Extract

1992 • 48 citations

Replication of Template-Primers Containing Propanodeoxyguanosine by DNA Polymerase β

1997 • 42 citations

Involvement of Phenylalanine 272 of DNA Polymerase Beta in Discriminating between Correct and Incorrect Deoxynucleoside Triphosphates

1999 • 41 citations

Transition between different binding modes in rat DNA polymerase β-ssDNA complexes

1998 • 39 citations

DNA Polymerase β in Abasic Site Repair: A Structurally Conserved Helix−Hairpin−Helix Motif in Lesion Detection by Base Excision Repair Enzymes

1997 • 39 citations

Changes in the DNA polymerase β gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination

1990 • 37 citations

DNA Polymerases α and β Are Required for DNA Repair in an Efficient Nuclear Extract from Xenopus Oocytes

1996 • 36 citations

Fidelity and Mutational Specificity of Uracil-initiated Base Excision DNA Repair Synthesis in Human Glioblastoma Cell Extracts

1998 • 34 citations

Active-site modification of mammalian DNA polymerase .beta. with pyridoxal 5'-phosphate: mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket

1989 • 34 citations

Insights into the mechanism of the β-elimination catalyzed by the N-terminal domain of DNA polymerase β

1997 • 17 citations