Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB

STATs and Gene Regulation

1997 • 3,927 citations

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

1999 • 2,796 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Calcium - a life and death signal

1998 • 2,040 citations

Efficient Initiation of HCV RNA Replication in Cell Culture

2000 • 1,412 citations

Free radicals, antioxidant enzymes, and carcinogenesis

1990 • 1,090 citations

Internal ribosome entry site within hepatitis C virus RNA

1992 • 914 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA

1997 • 718 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Replication of hepatitis C virus

2000 • 625 citations

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

1998 • 603 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

Hepatitis C and hepatocellular carcinoma

1997 • 565 citations

Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties

2000 • 505 citations

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

2001 • 436 citations

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism

1993 • 435 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease

2000 • 357 citations

Signal Transduction From the Endoplasmic Reticulum to the Cell Nucleus

1999 • 354 citations

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.

1993 • 342 citations

Cellular Factors in the Transcription and Replication of Viral RNA Genomes: A Parallel to DNA-Dependent RNA Transcription

1998 • 279 citations

Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner

2001 • 248 citations

Hepatitis C Virus RNA Polymerase and NS5A Complex with a SNARE-like Protein

1999 • 246 citations

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

1999 • 229 citations

Production of Two Phosphoproteins from the NS5A Region of the Hepatitis C Viral Genome

1994 • 217 citations

Activation of NF‐κB by ER stress requires both Ca²⁺ and reactive oxygen intermediates as messengers

1996 • 215 citations

Regulation of mitochondrial metabolism by ER Ca 2+ release: an intimate connection

2000 • 213 citations

Genetic Analysis of Internal Ribosomal Entry Site on Hepatitis C Virus RNA: Implication for Involvement of the Highly Ordered Structure and Cell Type-Specific Transacting Factors

1997 • 209 citations

Activation of nuclear factor ?B in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis

2000 • 188 citations

Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

1997 • 177 citations

Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth.

1999 • 172 citations

Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B

1999 • 165 citations

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

1997 • 150 citations

Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

1998 • 149 citations

Expression of Hepatitis C Virus Proteins Interferes with the Antiviral Action of Interferon Independently of PKR-Mediated Control of Protein Synthesis

2000 • 123 citations

Internal Ribosome Entry Site-Mediated Translation in Hepatitis C Virus Replication

2000 • 110 citations

Severe impairment of antioxidant system in human hepatoma

1986 • 105 citations

Involvement of intracellular Ca²⁺ in oxidant‐induced NF‐κB activation

1996 • 105 citations

Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.

1994 • 90 citations

Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase.

1996 • 78 citations

Preface: STAT signaling

2000 • 58 citations

Apoptosis : a practical approach

1999 • 54 citations

White House Enlists Science for Public Education Effort

1997 • 11 citations

Metabolic alterations associated with apoptosis

1999 • 8 citations