Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Principles of CDK regulation

1995 • 3,267 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.

1995 • 638 citations

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

1998 • 603 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

1996 • 412 citations

Initiation Of Eukaryotic DNA Replication In Vitro

1989 • 343 citations

Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells

1995 • 311 citations

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A

1995 • 281 citations

Transcriptional Repression of p53 Promoter by Hepatitis C Virus Core Protein

1997 • 274 citations

Molecular virology of hepatitis C virus.

1997 • 247 citations

Production of Two Phosphoproteins from the NS5A Region of the Hepatitis C Viral Genome

1994 • 217 citations

Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East.

1997 • 208 citations

Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.

1996 • 200 citations

The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

1995 • 182 citations

Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

1997 • 177 citations

Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines.

1995 • 162 citations

A reevaluation of the higher taxonomy of viruses based on RNA polymerases

1996 • 151 citations

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

1997 • 150 citations

Hepatitis C Virus Core from Two Different Genotypes Has an Oncogenic Potential but Is Not Sufficient for Transforming Primary Rat Embryo Fibroblasts in Cooperation with the H-rasOncogene

1998 • 136 citations

Cloning and characterization of a human c-myc promoter-binding protein.

1991 • 118 citations

Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells.

1992 • 81 citations

The Amino Terminal Deletion Mutants of Hepatitis C Virus Nonstructural Protein NS5A Function as Transcriptional Activators in Yeast

1997 • 77 citations

Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1.

1990 • 58 citations

Variability of the Hepatitis C Virus Genome

1998 • 54 citations

Induction of cell death in murine fibroblasts by a c-myc promoter binding protein.

1995 • 36 citations