Glycosidases of the asparagine-linked oligosaccharide processing pathway

Biological roles of oligosaccharides: all of the theories are correct

1993 • 5,121 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Catalytic mechanism of enzymic glycosyl transfer

1990 • 1,502 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control.

1994 • 815 citations

Quality control in the secretory pathway

1995 • 679 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

Glycoside Hydrolases: Mechanistic Information from Studies with Reversible and Irreversible Inhibitors

1990 • 544 citations

Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum

1995 • 544 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

Glycoprotein biosynthesis in yeast

1993 • 514 citations

Biosynthetic Controls That Determine the Branching and Microheterogeneity of Protein-Bound Oligosaccharides

1986 • 510 citations

Amino-sugar glycosidase inhibitors: versatile tools for glycobiologists

1992 • 488 citations

The Molecular Chaperone Calnexin Binds Glc1Man9GlcNAc2 Oligosaccharide as an Initial Step in Recognizing Unfolded Glycoproteins

1995 • 417 citations

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates.

1994 • 395 citations

Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides.

1979 • 390 citations

Glycosidase inhibitors: inhibitors of N‐linked oligosaccharide processing

1991 • 373 citations

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

1988 • 336 citations

Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II

1993 • 336 citations

Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.

1994 • 336 citations

The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein

1978 • 335 citations

Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.

1990 • 313 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

Inhibitors of carbohydrate processing: A new class of anticancer agents.

1995 • 305 citations

alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.

1982 • 294 citations

Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases.

1982 • 285 citations

The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides

1978 • 282 citations

Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins.

1995 • 274 citations

The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase.

1995 • 268 citations

Synthesis and processing of protein-linked oligosaccharides in vivo.

1979 • 259 citations

Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin

1983 • 251 citations

Glucose removal from N-linked oligosaccharides is required for efficient maturation of certain secretory glycoproteins from the rough endoplasmic reticulum to the Golgi complex.

1984 • 242 citations

Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.

1979 • 228 citations

Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.

1980 • 227 citations

Insect Cells Contain an Unusual, Membrane-bound β-N-Acetylglucosaminidase Probably Involved in the Processing of Protein N-Glycans

1995 • 208 citations

Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.

1994 • 183 citations

Golgi endo-alpha-D-mannosidase from rat liver, a novel N-linked carbohydrate unit processing enzyme.

1987 • 183 citations

Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.

1977 • 178 citations

Effects of the imino sugar N-butyldeoxynojirimycin on the N-glycosylation of recombinant gp120.

1993 • 172 citations

Glycoprotein synthesis in yeast. Identification of Man8GlcNAc2 as an essential intermediate in oligosaccharide processing.

1982 • 172 citations

Mammalian α-mannosidases—multiple forms but a common purpose?

1994 • 167 citations

Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine‐linked oligosaccharides

1984 • 165 citations

Evidence for an alpha-mannosidase in endoplasmic reticulum of rat liver.

1983 • 164 citations

Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.

1991 • 155 citations

Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase.

1981 • 154 citations

Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.

1980 • 153 citations

Evaluation of the role of rat liver Golgi endo-alpha-D-mannosidase in processing N-linked oligosaccharides.

1988 • 151 citations

The use of inhibitors in the study of glycosidases

1982 • 145 citations

N-Glycosylation in trypanosomatid protozoa

1993 • 143 citations

The carbohydrate‐deficient glycoprotein syndromes: An overview

1993 • 143 citations

Purification and characterization of glucosidase II, an endoplasmic reticulum hydrolase involved in glycoprotein biosynthesis.

1982 • 138 citations

Structures of the N-Linked Oligosaccharides of the Membrane Glycoproteins from Three Lepidopteran Cell Lines (Sf-21, IZD-Mb-0503, Bm-N)

1994 • 138 citations

A New α-d-Mannosidase Occurring in Golgi Membranes

1973 • 137 citations

The use of 1-deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells.

1986 • 137 citations

Novel alpha-D-mannosidase of rat sperm plasma membranes: characterization and potential role in sperm-egg interactions.

1989 • 130 citations

Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans.

1991 • 129 citations

Molecular Cloning and Expression of Rat Squalene Epoxidase

1995 • 125 citations

A novel pathway of import of alpha-mannosidase, a marker enzyme of vacuolar membrane, in Saccharomyces cerevisiae.

1990 • 125 citations

Purification and characterization of rat liver alpha-N-acetylglucosaminyl phosphodiesterase.

1981 • 122 citations

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Isolation and characterization of the gene encoding a specific processing alpha-mannosidase

1991 • 117 citations

Early steps in processing of yeast glycoproteins.

1984 • 114 citations

The calmodulin-binding domain mediates the self-association of the plasma membrane Ca2+ pump.

1991 • 113 citations

Processing of the carbohydrate units of thyroglobulin.

1981 • 112 citations

A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme.

1982 • 110 citations

Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides

1980 • 106 citations

Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II.

1990 • 106 citations

Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.

1980 • 106 citations

Immunolocalization of the oligosaccharide trimming enzyme glucosidase II.

1986 • 104 citations

Purification and properties of glucosidase I from mung bean seedlings

1986 • 102 citations

Characterization of a specific alpha-mannosidase involved in oligosaccharide processing in Saccharomyces cerevisiae.

1985 • 102 citations

Nucleotide sequence ofAMS1, the structure gene of vacuolarα-mannosidase of Saccharomyces cerevisiae

1989 • 102 citations

Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processing

1989 • 101 citations

Purification and characterization of the alpha-D-mannosidase of rat liver cytosol.

1976 • 101 citations

Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.

1995 • 98 citations

Release of glucose-containing polymannose oligosaccharides during glycoprotein biosynthesis. Studies with thyroid microsomal enzymes and slices.

1983 • 98 citations

Isolation of a homogeneous glucosidase II from pig kidney microsomes

1984 • 97 citations

The soluble form of rat liver alpha-mannosidase is immunologically related to the endoplasmic reticulum membrane alpha-mannosidase.

1986 • 97 citations

The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats.

1990 • 94 citations

Purification and characterization of a neutral processing mannosidase from calf liver acting on (Man)₉(GlcNAc)₂ oligosaccharides

1986 • 93 citations

Processing of carbohydrate units of glycoproteins. Characterization of a thyroid glucosidase.

1979 • 88 citations

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Purification of the alpha-mannosidase which removes one specific mannose residue from Man9GlcNAc.

1988 • 87 citations

Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.

1981 • 87 citations

Inhibition of glucose trimming by castanospermine results in rapid degradation of unassembled major histocompatibility complex class I molecules.

1993 • 86 citations

Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals

1994 • 86 citations

Calnexin Fails to Associate with Substrate Proteins in Glucosidase-deficient Cell Lines

1995 • 86 citations

Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol.

1982 • 84 citations

Co-translational excision of alpha-glucose and alpha-mannose in nascent vesicular stomatitis virus G protein.

1984 • 83 citations

HEMPAS disease: genetic defect of glycosylation

1990 • 83 citations

Biosynthesis and processing of ribophorins in the endoplasmic reticulum.

1984 • 83 citations

Inhibitors of protein glycosylation and glycoprotein processing in viral systems

1987 • 82 citations

Purification to homogeneity and properties of mannosidase II from mung bean seedlings

1990 • 80 citations

Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase.

1990 • 79 citations

Calnexin: a molecular chaperone with a taste for carbohydrate

1995 • 79 citations

Cloning and Expression of Glucosidase I from Human Hippocampus

1995 • 78 citations

Purification to homogeneity and properties of glucosidase II from mung bean seedlings and suspension-cultured soybean cells.

1990 • 77 citations

Isolation and expression of murine and rabbit cDNAs encoding an alpha 1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides

1994 • 77 citations

Endoplasmic reticulum-to-cytosol transport of free polymannose oligosaccharides in permeabilized HepG2 cells.

1995 • 75 citations

Comparison between 1-deoxynojirimycin and N-methyl-1-deoxynojirimycin as inhibitors of oligosaccharide processing in intestinal epithelial cells

1985 • 73 citations

The purification and characterization of mannosidase IA from rat liver Golgi membranes.

1988 • 72 citations

Enzymatic excision of glucosyl units linked to the oligosaccharide chains of glycoproteins

1978 • 72 citations

Potential regulation of N-glycosylation precursor through oligosaccharide-lipid hydrolase action and glucosyltransferase-glucosidase shuttle.

1991 • 70 citations

Molecular cloning and primary structure of Man₉‐mannosidase from human kidney

1993 • 69 citations

Microsomal Glucosidases of Rat Liver. Partial Purification and Inhibition by Disaccharides

2005 • 68 citations

Purification and Properties of a Glycoprotein Processing α-Mannosidase from Mung Bean Seedlings

1986 • 67 citations

Purification and characterization of a phospholipid-dependent alpha-mannosidase from rabbit liver.

1981 • 67 citations

Evidence for a non-lysosomal α-mannosidase in rat liver homogenates

1971 • 66 citations

Characterization of endomannosidase inhibitors and evaluation of their effect on N-linked oligosaccharide processing during glycoprotein biosynthesis

1993 • 66 citations

Substrate specificities of rat kidney lysosomal and cytosolic alpha-D-mannosidases and effects of swainsonine suggest a role of the cytosolic enzyme in glycoprotein catabolism.

1987 • 64 citations

Characterization of trimming Man9-mannosidase from pig liver. Purification of a catalytically active fragment and evidence for the transmembrane nature of the intact 65 kDa enzyme

1989 • 63 citations

Molecular and Genetic Analysis of the Drosophila mas-1 (mannosidase-1) Gene Which Encodes a Glycoprotein Processing α1,2-Mannosidase

1995 • 61 citations

Transformation by the v-fms oncogene product: role of glycosylational processing and cell surface expression.

1985 • 61 citations

Action of glycosidases on the saccharide moiety of the glucose—containing dolichyl diphosphate oligosaccharide

1978 • 59 citations

Mannostatin A, a new glycoprotein-processing inhibitor

1990 • 59 citations

Catabolism of glycan moieties of lipid intermediates leads to a single Man₅GlcNAc oligosaccharide isomer: a study with permeabilized CHO cells

1995 • 58 citations

Effect of substrate structure on the activity of Man₉‐mannosidase from pig liver involved in N‐linked oligosaccharide processing

1992 • 58 citations

Purification and characterization of a novel broad‐specificity (α1 → 2, α1 → 3 and α1 → 6) mannosidase from rat liver

1991 • 57 citations

Phosphorylation of the oligosaccharide of uteroferrin by UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferases from rat liver, Acanthamoeba castellani, and Dictyostelium discoideum requires alpha 1,2-linked mannose residues.

1986 • 55 citations

Nonselective utilization of the endomannosidase pathway for processing glycoproteins by human hepatoma (HepG2) cells.

1992 • 54 citations

Purification and characterization of trimming glucosidase I from pig liver

1989 • 54 citations

Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannojirimycin-sensitive alpha-mannosidase activities.

1988 • 53 citations

Purification and characterization of glucosidase II involved in N-linked glycoprotein processing in bovine mammary gland

1987 • 53 citations

.alpha.-Mannosidase-catalyzed trimming of high-mannose glycans in noninfected and baculovirus-infected Spodoptera frugiperda cells (IPLB-SF-21AE). A possible contributing regulatory mechanism for assembly of complex-type oligosaccharides in infected cells

1991 • 53 citations

Human Lysosomal Alpha-Mannosidase: Isolation and Nucleotide Sequence of the Full-Length cDNA

1994 • 52 citations

Processing of asparagine-linked oligosaccharides in insect cells: evidence for ?-mannosidase II

1995 • 52 citations

Clinical Aspects of Glycoprotein Biosynthesis

1993 • 51 citations

Isolation of a rat liver Golgi mannosidase II clone by mixed oligonucleotide-primed amplification of cDNA.

1989 • 51 citations

Characterization of a novel alpha-D-mannosidase from rat brain microsomes.

1985 • 49 citations

Release of oligomannoside-type glycans as a marker of the degradation of newly synthesized glycoproteins

1994 • 49 citations

Demonstration of the enzymatic mechanisms of α-N-acetyl-d-glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called α-N-acetylglucosaminylphosphodiesterase) and lysosomal α-N-acetylglucosaminidase

1983 • 49 citations

Microsomal glucosidases acting on the saccharide moiety of the glucose-containing dolichyl diphosphate oligosaccharide

1979 • 49 citations

Substrate specificity of rat liver cytosolic α‐<scp>d</scp>‐mannosidase Novel degradative pathway for oligomannosidic type glycans

1991 • 48 citations

Studies on the Substrate Specificity of Neutral α-Mannosidase Purified from Japanese Quail Oviduct by Using Sugar Chains from Glycoproteins1

1991 • 48 citations

Processing of MOPC 315 immunoglobulin A oligosaccharides: evidence for endoplasmic reticulum and trans Golgi alpha 1,2-mannosidase activity.

1984 • 47 citations

Purification and characterization of an α-1,2-mannosidase involved in processing asparagine-linked oligosaccharides

1989 • 47 citations

alpha-Glucosidase II-deficient cells use endo alpha-mannosidase as a bypass route for N-linked oligosaccharide processing

1991 • 47 citations

Calcium ion activation of rabbit liver alpha 1,2-mannosidase.

1990 • 46 citations

Glucosidase II, a glycoprotein of the endoplasmic reticulum membrane. Proteolytic cleavage into enzymically active fragments

1985 • 46 citations

Glycoprotein biosynthesis in yeast: purification and characterization of the endoplasmic reticulum Man₉ processing α-mannosidase

1991 • 45 citations

A glucosylated oligosaccharide lipid intermediate in calf brain. Evidence for the transfer of the oligosaccharide into membrane glycoprotein and subsequent removal of glucosyl residues.

1979 • 44 citations

Purification and characterization of trimming glucosidase I from Saccharomyces cerevisiae

1986 • 43 citations

Molecular cloning and nucleotide sequence of the 1,2-α-d-mannosidase gene, msdS, from Aspergillus saitoi and expression of the gene in yeast cells

1995 • 43 citations

Cloning and sequence analysis of GmII, a Drosophila melanogaster homologue of the cDNA encoding murine Golgi α-mannosidase II

1995 • 43 citations

Transfer of nonglucosylated oligosaccharide from lipid to protein in a mammalian cell.

1986 • 42 citations

Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies.

1985 • 41 citations

Molecular cloning and characterization of the structural gene coding for the developmentally regulated lysosomal enzyme, alpha-mannosidase, in Dictyostelium discoideum.

1992 • 41 citations

Cell type-specific post-Golgi apparatus localization of a "resident" endoplasmic reticulum glycoprotein, glucosidase II.

1990 • 40 citations

Effect of bromoconduritol on glucosidase II from rat liver

1993 • 38 citations

Purification and characterization of rat epididymal-fluid α-<scp>d</scp>-mannosidase: similarities to sperm plasma-membrane α-<scp>d</scp>-mannosidase

1993 • 38 citations

Characterization of a mannosidase acting on α1 → 3‐ and α1 → 6‐linked mannose residues of oligomannosidic intermediates of glycoprotein processing

1987 • 36 citations

A human lysosomal alpha-mannosidase specific for the core of complex glycans.

1992 • 36 citations

Purification and Properties of a Golgi-Derived (.alpha.1,2)-Mannosidase-I from Baculovirus-Infected Lepidopteran Insect Cells (IPLB-SF21AE) with Preferential Activity toward Mannose6-N-Acetylglucosamine2

1995 • 35 citations

Disruption of the processing α-mannosidase gene does not prevent outer chain synthesis in Saccharomyces cerevisiae

1993 • 35 citations

Molecular cloning and nucleotide sequence of the genomic DNA for 1,2-α-d-mannosidase gene, msdC from Penicillium citrinum

1995 • 34 citations

Man₉‐Mannosidase from Human Kidney is Expressed in COS Cells as a Golgi‐Resident Type II Transmembrane N‐Glycoprotein

1995 • 34 citations

Deoxynojirimycin inhibits the formation of Glc₃Man₉GlcNAc₂‐PP‐dolichol in intestinal epithelial cells in culture

1985 • 32 citations

Catabolic pathway of oligosaccharide-diphospho-dolichol. Study of the fate of the oligosaccharidic moiety in mouse splenocytes

1987 • 31 citations

The Saccharomyces cerevisiae Processing α1,2-Mannosidase Is an Inverting Glycosidase

1995 • 30 citations

Subcellular distribution in rat liver of a novel broad‐specificity (α1 → 2, α1 → 3 and α1 → 6) mannosidase active on oligomannose glycans

1992 • 28 citations

Glucosidase II from rat liver microsomes. Kinetic model for binding and hydrolysis

1991 • 28 citations

Production, purification and characterization of recombinant yeast processing αl,2-mannosidase

1994 • 28 citations

Oligosaccharide trimming Man9-mannosidase is a resident ER protein and exhibits a more restricted and local distribution than glucosidase II.

1990 • 27 citations

Soluble forms of α‐<scp>d</scp>‐mannosidases from rat liver

1994 • 26 citations

Ricin-resistant mutants of baby-hamster-kidney cells deficient in alpha-mannosidase-II-catalyzed processing of asparagine-linked oligosaccharides

1986 • 25 citations

Enzymatic cleavage of glycosides: How does it happen?

1995 • 24 citations

Ligand affinity chromatographic purification of rat liver Golgi endomannosidase.

1994 • 22 citations

Purification and Characterization of Neutral α-Mannosidase That Is Activated by Co2+ from Japanese Quail Oviduct1

1991 • 22 citations

Inhibition of myoblast fusion by the glucosidase inhibitor N-methyl-1-deoxynojirimycin, but not by the mannosidase inhibitor 1-deoxymannojirimycin

1986 • 20 citations

Purification and kinetic parameters of bovine liver N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase.

1994 • 19 citations

Topology of ER processing α-mannosidase of Saccharomyces cerevisae

1992 • 18 citations

Characterization of a novel mouse recombinant processing α-mannosidase

1994 • 18 citations

Purification and Characterization of Human Serum N-Acetylglucosamine-1-phosphodiester α-N-Acetylglucosaminidase

1995 • 18 citations

Inhibition of myoblast fusion by bromoconduritol

1988 • 18 citations

Continuous Foreign Gene Expression in Transformed Lepidopteran Insect Cells

2003 • 17 citations

Characterization and immunolocalization of bovine N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase.

1994 • 16 citations

Effect of phospholipids on alpha-1,2-mannosidase activity.

1982 • 16 citations

Asparagine-linked glycoprotein biosynthesis in rat brain: Identification of glucosidase I, glucosidase II, and an endomannosidase (glucosyl mannosidase)

1990 • 13 citations

Role of sulfhydryl groups in the function of glucosidase I from mammary gland.

1993 • 12 citations

Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11

1983 • 10 citations

Chemical modification of Penicillium 1,2-α-<scp>d</scp>-mannosidase by water-soluble carbodi-imide: identification of a catalytically important aspartic acid residue

1994 • 9 citations

Bromoconduritol treatment delays intracellular transport of secretory glycoproteins in human hepatoma cell cultures

1989 • 7 citations

S2.26 Cloning of a murine homolog of theDictyostelium disciodeum lysosomal?-mannosidase

1993 • 3 citations

S2.25 Isolation of a mouse cDNA encoding a processing mannosidase

1993 • 1 citations