Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

β-Cell death during progression to diabetes

2001 • 883 citations

Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry

2000 • 690 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice

1998 • 572 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

1997 • 359 citations

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

2000 • 344 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

Development of Spontaneous Autoimmune Peripheral Polyneuropathy in B7-2–Deficient Nod Mice

2001 • 225 citations

Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

1996 • 211 citations

Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes

1986 • 184 citations

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

1998 • 179 citations

Induction of Glutamic Acid Decarboxylase 65-Specific Th2 Cells and Suppression of Autoimmune Diabetes at Late Stages of Disease Is Epitope Dependent

1999 • 173 citations

Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation

2001 • 172 citations

Differential Expression of GAD65 and GAD67 in Human, Rat, and Mouse Pancreatic Islets

1993 • 165 citations

Genetic and pathogenic basis of autoimmune diabetes in NOD mice

1994 • 136 citations

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains.

1996 • 130 citations

Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study

2002 • 127 citations

Conditional Ablation of Cerebellar Astrocytes in Postnatal Transgenic Mice

1996 • 124 citations

Regulation of naive T cell differentiation by varying the potency of TCR signal transduction

1999 • 102 citations

Intermolecular Antigen Spreading Occurs During the Preclinical Period of Human Type 1 Diabetes

2001 • 93 citations

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

1995 • 93 citations

Type I Diabetes and Multiple Sclerosis Patients Target Islet Plus Central Nervous System Autoantigens; Nonimmunized Nonobese Diabetic Mice Can Develop Autoimmune Encephalitis

2001 • 85 citations

β-Cell Destruction May Be a Late Consequence of the Autoimmune Process in Nonobese Diabetic Mice

1996 • 77 citations

Mycobacterium leprae-Specific, HLA Class II-Restricted Killing of Human Schwann Cells by CD4+ Th1 Cells: A Novel Immunopathogenic Mechanism of Nerve Damage in Leprosy

2001 • 75 citations

The use of Seldi ProteinChip? Arrays to monitor production of Alzheimer's ?-amyloid in transfected cells

2000 • 72 citations

Persistent T Cell Anergy in Human Type 1 Diabetes

1999 • 66 citations

Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells

1998 • 61 citations

Morphological Characteristics of Schwann Cells in the Islets of Langerhans of the Murine Pancreas.

2001 • 52 citations

Gene Expression of Islet Cell Antigen p69 in Human, Mouse, and Rat

1996 • 35 citations

ICA69null Nonobese Diabetic Mice Develop Diabetes, but Resist Disease Acceleration by Cyclophosphamide

2002 • 31 citations

Ultrastructural evidence for the presence of a glial sheath investing the islets of Langerhans in the pancreas of mammals

1984 • 30 citations

Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse.

1996 • 27 citations

Structural modification of Schwann cells in the pancreatic islets of the dog

1975 • 26 citations

Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms

1995 • 23 citations

Peptide Dose, MHC Affinity, and Target Self-Antigen Expression Are Critical for Effective Immunotherapy of Nonobese Diabetic Mouse Prediabetes

2000 • 21 citations

Histophysiology of the Obesity-Diabetes Syndrome in Sand Rats

1994 • 6 citations

Introduction

1994 • 2 citations