Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Techniques of Autoradiography

1967 • 1,151 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Techniques of autoradiography

1967 • 1,044 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Diabetogenic action of streptozotocin: relationship of dose to metabolic response

1969 • 950 citations

p75 and Trk: A two-receptor system

1995 • 861 citations

Studies on the diabetogenic action of streptozotocin

1963 • 831 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

1994 • 685 citations

The nerve growth factor family of receptors

1992 • 649 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

Diabetes Mellitus: Theory and Practice.

1971 • 559 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

Epitheliomesenchymal interaction in pancreatic morphogenesis

1962 • 409 citations

Studies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury.

1980 • 402 citations

Nerve growth factor induces growth and differentiation of human B lymphocytes.

1989 • 386 citations

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

1993 • 371 citations

Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

1994 • 343 citations

Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effects

1967 • 326 citations

Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice

1993 • 325 citations

Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration

1993 • 313 citations

Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: development and regulation by neuron–Schwann cell interactions

1990 • 277 citations

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

1988 • 241 citations

Differentiation of New Insulin-Producing Cells Is Induced by Injury in Adult Pancreatic Islets¹

1997 • 231 citations

TrkA cross-linking mimics neuronal responses to nerve growth factor.

1994 • 222 citations

Some characteristics of histamine secretion from rat peritoneal mast cells stimulated with nerve growth factor.

1986 • 199 citations

On the origin of pancreatic endocrine cells

1988 • 195 citations

Streptozotocin Diabetes in the Mouse and Guinea Pig

1969 • 172 citations

Reciprocal Schwann cell-axon interactions

1993 • 156 citations

Transforming growth factor-beta 1 regulates axon/Schwann cell interactions.

1995 • 153 citations

Spatiotemporal patterns of expression of NGF and the low-affinity NGF receptor in rat embryos suggest functional roles in tissue morphogenesis and myogenesis

1992 • 147 citations

Ultrastructural studies of early morphogenesis and cytodifferentiation in the embryonic mammalian pancreas

1968 • 145 citations

Cell lineage analysis of pancreatic islet cell development: Glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct

1987 • 136 citations

Neurotrophins Cause a New Sensation

1996 • 136 citations

Peripheral nerve injury

1994 • 111 citations

Peripheral nerve regeneration: Role of growth factors and their receptors

1993 • 110 citations

Histological studies on the neuro-insular complex in the pancreas of some mammals

1959 • 98 citations

Developmental Biology

1990 • 94 citations

Expression of human nerve growth factor receptor on cells derived from all three germ layers

1988 • 86 citations

Developmental biology (3rd edn)

1992 • 80 citations

In vivo presence of the high affinity nerve growth factor receptor Trk-A in the rat pancreas: differential localization during pancreatic development.

1995 • 56 citations

Presence of nerve growth factor and its receptors in an in vitro model of islet cell development: implication in normal islet morphogenesis.

1995 • 56 citations

Expression of Functional Nerve Growth Factor Receptors in Pancreatic β-cell Lines and Fetal Rat Islets in Primary Culture

1993 • 56 citations

Induction of endocrine cell differentiation: a new approach to management of diabetes.

1989 • 51 citations

Nerve Growth Factor as a Mitogen for a Pancreatic Carcinoid Cell Line

1995 • 30 citations

Ultrastructural evidence for the presence of a glial sheath investing the islets of Langerhans in the pancreas of mammals

1984 • 30 citations

Immunostaining of a cell type in the islets of Langerhans of the monkey Macaca irus by antibodies against S-100 protein

1987 • 27 citations

Morphological and functional aspects of pancreatic islet innervation

1983 • 27 citations

Spontaneous Diabetes in Animals

1977 • 27 citations

DARPP-32 promoter directs transgene expression to renal thick ascending limb of loop of Henle

1995 • 23 citations

Spontaneous Diabetes in Animals

1985 • 11 citations