Directex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Phototyping: comprehensive DNA typing for HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence‐specific primers (PCR‐SSP)

1995 • 1,018 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8⁺and CD4⁺T lymphocytes

2000 • 392 citations

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division

1998 • 379 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

1997 • 235 citations

Specificity of CTL Interactions with Peptide-MHC Class I Tetrameric Complexes Is Temperature Dependent

1999 • 197 citations

Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells

1997 • 169 citations

Detection of Low HIV-1 RNA Levels in Plasma

1997 • 156 citations

Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency

1993 • 147 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice.

1995 • 116 citations

T cell responses are governed by avidity and co‐stimulatory thresholds

1996 • 107 citations

A rapid and simple method for extracting human immunodeficiency virus type 1 RNA from plasma: enhanced sensitivity

1997 • 79 citations

Homeostatic regulation of CD8⁺ T cells after antigen challenge in the absence of Fas (CD95)

1996 • 70 citations

Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

2000 • 70 citations

T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions

1996 • 66 citations

Agonist‐induced T cell receptor down‐regulation: molecular requirements and dissociation from T cell activation

1997 • 66 citations

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

1998 • 51 citations

Four types of Ca²⁺ signals in naive CD8⁺ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists

1997 • 26 citations

Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation

1998 • 24 citations

T cell receptor α‐chain tail is required for protein kinase C‐mediated down‐regulation, but not for signaling

1997 • 20 citations