Control of the Cell Morphology and the S Phase Entry by Mitogen-activated Protein Kinase Kinase

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

1998 • 1,003 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

1996 • 326 citations

Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.

1995 • 269 citations

Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation

1998 • 230 citations

Mesoderm induction in Xenopus caused by activation of MAP kinase

1995 • 223 citations

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1

1994 • 214 citations

A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade

1997 • 181 citations

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

1993 • 179 citations

Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

1995 • 172 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

Constitutive activation of Mek1 by mutation of serine phosphorylation sites.

1994 • 145 citations

Involvement of the MAP kinase cascade in Xenopus mesoderm induction.

1995 • 136 citations

Biochemical and biological analysis of Mek1 phosphorylation site mutants.

1995 • 113 citations

Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.

1989 • 103 citations

Biochemical Properties of a Highly Purified v-ras^H p21 Protein Overproduced in Escherichia coli and Inhibition of Its Activities by a Monoclonal Antibody

1985 • 65 citations

Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.

1994 • 57 citations