Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

1999 • 257 citations

Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways

1999 • 230 citations

Dysregulation of Apoptosis as a Mechanism of Liver Disease: An Overview

1998 • 189 citations

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1998 • 187 citations

The transforming growth factor ?1-inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress

1999 • 157 citations

Inherent increase of apoptosis in liver tumors: Implications for carcinogenesis and tumor regression

1997 • 150 citations

EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL

1998 • 112 citations

Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor ? in fetal rat hepatocytes in primary culture

1997 • 105 citations

The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor ?-mediated rat hepatocyte survival and apoptosis

2000 • 103 citations

Activation of caspase-8 in transforming growth factor-?-induced apoptosis of human hepatoma cells

1999 • 99 citations

Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

1999 • 92 citations

Inhibition by dexamethasone of transforming growth factor ?1,-induced apoptosis in rat hepatoma cells: A possible association with Bcl-xL induction

1998 • 83 citations

Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens.

1998 • 82 citations

Involvement of caspase family proteases in transforming growth factor-beta-induced apoptosis.

1997 • 81 citations

Regulation of Bcl-x_Lexpression in human keratinocytes by cell–substratum adhesion and the epidermal growth factor receptor

1997 • 80 citations

Apoptosis in the liver and its role in hepatocarcinogenesis.

1997 • 77 citations

Role for Bcl-xLin the Regulation of Apoptosis by EGF and TGFβ1 in c-myc Overexpressing Mammary Epithelial Cells

1996 • 75 citations

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor‐beta in fetal hepatocytes in primary culture

1996 • 70 citations

Dysregulation of Apoptosis in Hepatocellular Carcinoma

1998 • 70 citations

Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones

1992 • 67 citations

Induction of p53 and Bax during TGF-β1 Initiated Apoptosis in Rat Liver Epithelial Cells

1998 • 64 citations

Transforming growth factor β modulates growth and differentiation of fetal hepatocytes in primary culture

1995 • 60 citations

Hepatocyte death in hepatocarcinogenesis

1998 • 52 citations

Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: hormonal effects

1989 • 32 citations

Measurement of the activity of individual respiratory chain complexes in isolated fibroblast mitochondria

1992 • 27 citations

Phorbol esters down-regulate alpha-fetoprotein gene expression without affecting growth in fetal hepatocytes in primary culture

1998 • 11 citations

Effect of phorbol ester (PMA) on antioxidant enzyme expression in TGF‐β1‐induced apoptosis in primary cultures of hepatocytes

1998 • 6 citations