The Ras/Rac1/Cdc42/SEK/JNK/c-Jun Cascade Is a Key Pathway by Which Agonists Stimulate DNA Synthesis in Primary Cultures of Rat Hepatocytes

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Liver Regeneration

1997 • 2,731 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli

1996 • 655 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway

1996 • 430 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Tumor Necrosis Factor ä-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways

1997 • 355 citations

Growth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro

1996 • 225 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Activation of the JNK pathway is essential for transformation by the Met oncogene

1997 • 183 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex.

1993 • 166 citations

Coordinate Regulation of Stress- and Mitogen-Activated Protein Kinases in the Apoptotic Actions of Ceramide and Sphingosine

1997 • 153 citations

Induction of early-immediate genes by tumor necrosis factor ? contribute to liver repair following chemical-induced hepatotoxicity

1997 • 152 citations

Activation of Jun kinase is an early event in hepatic regeneration.

1995 • 150 citations

S6 Phosphorylation and the p70^s6k/p85^s6k

1994 • 148 citations

Regulation of Raf-1 and Raf-1 Mutants by Ras-Dependent and Ras-Independent Mechanisms In Vitro

1995 • 140 citations

Induction of Apoptosis and Potentiation of Ceramide-mediated Cytotoxicity by Sphingoid Bases in Human Myeloid Leukemia Cells

1996 • 136 citations

Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury

1994 • 129 citations

Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-α in adult rat liver

1994 • 129 citations

Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats

1996 • 110 citations

Differential Regulation of the Mitogen-Activated Protein and Stress-Activated Protein Kinase Cascades by Adrenergic Agonists in Quiescent and Regenerating Adult Rat Hepatocytes

1997 • 110 citations

Signal transduction pathways involving the raf proto-oncogene

1994 • 99 citations

p120 GAP Modulates Ras Activation of Jun Kinases and Transformation

1997 • 97 citations

Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase

1996 • 97 citations

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

1997 • 71 citations

Phosphatidylinositol 3-Kinase Activity Is Required for Hepatocyte Growth Factor-induced Mitogenic Signals in Epithelial Cells

1996 • 56 citations

Tumor necrosis factor–alpha modulates CCAAT/enhancer binding proteins–DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration

1995 • 50 citations

Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP

1997 • 48 citations

Hypoglycemia-induced c-Jun Phosphorylation Is Mediated by c-Jun N-terminal Kinase 1 and Lyn Kinase in Drug-resistant Human Breast Carcinoma MCF-7/ADR Cells

1997 • 44 citations

Cell cycle progression proteins (cyclins), oncogene expression, and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor

1996 • 36 citations

Positive and negative regulation of JNK1 by protein kinase C and p42^{MAP kinase} in adult rat hepatocytes

1997 • 31 citations

A comparative study of the hepatic mitogen-activated protein kinase and Jun-NH2-terminal kinase pathways in the late-gestation fetal rat.

1996 • 27 citations

Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells.

1997 • 23 citations

[12] Determination of guanine nucleotides bound to Ras in mammalian cells

1995 • 22 citations

Inverse Regulation of Hepatic α_1B‐ and β₂‐Adrenergic Receptors

1995 • 22 citations

Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo

1996 • 21 citations

Host-cell reactivation of reporter genes introduced into cells by adenovirus as a convenient way to measure cellular DNA repair

1995 • 14 citations

Deleted Work

1955 • 0 citations