The genetics of cell cycle checkpoints

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

1982 • 1,361 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1991 • 703 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

The Molecular biology of the yeast saccharomyces, life cycle and inheritance

1981 • 636 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

The Saccharomyces cerevisiae Cell Cycle

1981 • 539 citations

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

1994 • 502 citations

14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins

1992 • 483 citations

The cell cycle: an introduction

1994 • 466 citations

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

1993 • 464 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

1992 • 417 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Fission yeast genes involved in coupling mitosis to completion of DNA replication.

1992 • 382 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

1994 • 346 citations

14-3-3 Protein Homologs Required for the DNA Damage Checkpoint in Fission Yeast

1994 • 344 citations

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.

1991 • 329 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

1992 • 296 citations

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

1992 • 290 citations

Cell cycle checkpoints

1994 • 284 citations

Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.

1993 • 263 citations

Premature chromosome condensation in a ts DNA-mutant of BHK cells

1978 • 260 citations

Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid.

1993 • 254 citations

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase.

1994 • 231 citations

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+

1993 • 231 citations

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

1991 • 231 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

Checkpoint controls in Schizosaccharomyces pombe: rad1.

1992 • 224 citations

RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.

1993 • 195 citations

Coupling M phase and S phase: Controls maintaining the dependence of mitosis on chromosome replication

1991 • 183 citations

The cell cycle: an introduction

1994 • 164 citations

A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation

1990 • 152 citations

The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis?

1993 • 152 citations

Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.

1994 • 148 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.

1994 • 134 citations

The assembly of signalling complexes by receptor tyrosine kinases

1993 • 130 citations

Feedback controls and G2 checkpoints: Fission yeast as a model system

1993 • 113 citations

The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair.

1992 • 111 citations

RCC1, a Regulator of Mitosis, Is Essential for DNA Replication

1992 • 106 citations

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

1993 • 104 citations

Yeast pheromone response pathway: characterization of a suppressor that restores mating to receptorless mutants.

1989 • 98 citations

Fission yeast wee1 protein kinase is not required for DMA damage-dependent mitotic arrest

1993 • 87 citations

Cloning and characterization of therad4gene ofSchizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene

1991 • 72 citations

The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease.

1994 • 63 citations

Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae.

1991 • 57 citations

RCC1, a regulator of mitosis, is essential for DNA replication.

1992 • 46 citations