Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

The Protein Data Bank

2000 • 35,287 citations

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1993 • 26,634 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

1977 • 19,896 citations

The PyMOL Molecular Graphics System

2002 • 18,218 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

LINCS: A linear constraint solver for molecular simulations

1997 • 14,411 citations

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins

1998 • 13,827 citations

Comparative Protein Modelling by Satisfaction of Spatial Restraints

1993 • 12,640 citations

GROMACS: A message-passing parallel molecular dynamics implementation

1995 • 9,228 citations

GROMACS 3.0: a package for molecular simulation and trajectory analysis

2001 • 6,608 citations

Protein secondary structure prediction based on position-specific scoring matrices 1 1Edited by G. Von Heijne

1999 • 5,382 citations

Protein Structure Comparison by Alignment of Distance Matrices

1993 • 3,989 citations

Interactions with Aromatic Rings in Chemical and Biological Recognition

2003 • 3,313 citations

Comparative Protein Structure Modeling of Genes and Genomes

2000 • 3,120 citations

Analytical molecular surface calculation

1983 • 2,454 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Recognition of errors in three-dimensional structures of proteins

1993 • 2,084 citations

Modeling of loops in protein structures

2000 • 2,081 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

2006 • 1,686 citations

PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

1999 • 1,622 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

INDUCTION OF CYTOCHROME P4501A1

1999 • 1,124 citations

Evaluation of comparative protein modeling by M<scp>ODELLER</scp>

1995 • 1,066 citations

Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

1998 • 1,017 citations

AH RECEPTOR SIGNALING PATHWAYS

1996 • 898 citations

DaliLite workbench for protein structure comparison

2000 • 891 citations

The mammalian basic helix–loop–helix/PAS family of transcriptional regulators

2003 • 569 citations

Ligand binding and activation of the Ah receptor

2002 • 479 citations

An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies

1996 • 474 citations

Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction

2001 • 462 citations

Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus

1998 • 439 citations

1.4 .ANG. Structure of Photoactive Yellow Protein, a Cytosolic Photoreceptor: Unusual Fold, Active Site, and Chromophore

1995 • 433 citations

Large-scale protein structure modeling of the Saccharomyces cerevisiae genome

1998 • 358 citations

Structure of a biological oxygen sensor: A new mechanism for heme-driven signal transduction

1998 • 356 citations

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

1994 • 327 citations

Identification of Functional Domains of the Aryl Hydrocarbon Receptor

1995 • 322 citations

Analysis of the four alleles of the murine aryl hydrocarbon receptor.

1994 • 288 citations

The role of chaperone proteins in the aryl hydrocarbon receptor core complex

2002 • 282 citations

The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals

1998 • 254 citations

Induction of CYP1A1. The AhR / DRE Paradigm Transcription, Receptor Regulation, and Expanding Biological Roles

2001 • 221 citations

Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor

2003 • 218 citations

Current Protocols in Toxicology

2001 • 202 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Structure and Interactions of PAS Kinase N-Terminal PAS Domain

2002 • 152 citations

Structural Basis of ARNT PAS-B Dimerization: Use of a Common Beta-sheet Interface for Hetero- and Homodimerization

2005 • 140 citations

Solution Structure and Backbone Dynamics of the Photoactive Yellow Protein^,

1998 • 123 citations

Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation

2003 • 115 citations

Histidine−Aromatic Interactions in Proteins and Protein−Ligand Complexes: Quantum Chemical Study of X-ray and Model Structures

2005 • 113 citations

Physicochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocator: characterization of two monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator.

1994 • 110 citations

Definition of a Dioxin Receptor Mutant That Is a Constitutive Activator of Transcription

2001 • 97 citations

Crystal Structure and Interactions of the PAS Repeat Region of the Drosophila Clock Protein PERIOD

2005 • 89 citations

Structure of the NCoA-1/SRC-1 PAS-B Domain Bound to the LXXLL Motif of the STAT6 Transactivation Domain

2004 • 74 citations

The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression

2002 • 62 citations

Mapping the 90 kDa heat shock protein binding region of the Ah receptor

1996 • 60 citations

A model for recognition of polychlorinated dibenzo‐p‐dioxins by the aryl hydrocarbon receptor

2002 • 60 citations

Toxicant-Receptor Interactions

1998 • 57 citations

Analysis of the Aryl Hydrocarbon Receptor (<scp>Ah</scp><scp>R</scp>) Signal Transduction Pathway

2002 • 50 citations

Agonist but Not Antagonist Ligands Induce Conformational Change in the Mouse Aryl Hydrocarbon Receptor as Detected by Partial Proteolysis

2003 • 49 citations

Molecular Polarizability as a Tool for Understanding the Binding Properties of Polychlorinated Dibenzo-p-Dioxins: Definition of a Reliable Computational Procedure

1996 • 45 citations

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity

2005 • 40 citations

In vitro transformation of the human Ah receptor and its binding to a dioxin response element.

1992 • 33 citations

A hypothesis on the mechanism of PCDD biological activity based on molecular electrostatic potential modeling. Part 2

1995 • 28 citations

Aryl Hydrocarbon Receptor

2008 • 6 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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