Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

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1982 • 53,055 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

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Glutamate and the pathophysiology of hypoxic–ischemic brain damage

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The influence of immaturity on hypoxic‐ischemic brain damage in the rat

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1991 • 2,061 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

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1993 • 1,005 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1995 • 517 citations

Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis

1992 • 462 citations

Experimental Biology of Cerebral Hypoxia-Ischemia: Relation to Perinatal Brain Damage

1990 • 430 citations

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

1986 • 377 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat

1994 • 318 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

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Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death

1992 • 270 citations

Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations

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Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases.

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Apoptosis: the biochemistry and molecular biology of programmed cell death

1993 • 222 citations

Programmed Cell Death in Neurons: Focus on the Pathway of Nerve Growth Factor Deprivation-Induced Death of Sympathetic Neurons

1997 • 220 citations

Electron microscopic analysis of adrenalectomy‐induced hippocampal granule cell degeneration in the rat: Apoptosis in the adult central nervous system

1993 • 216 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

1996 • 192 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Marked age‐dependent neuroprotection by brain‐derived neurotrophic factor against neonatal hypoxic—ischemic brain injury

1997 • 185 citations

Cell Death During Development Of The Nervous System

1991 • 168 citations

CYTOKINES AND PERINATAL BRAIN INJURY

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The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Neurotransmitter alterations in a model of perinatal hypoxic‐ischemic brain injury

1983 • 158 citations

Nerve growth factor protects the neonatal brain against hypoxic–ischemic injury

1996 • 154 citations

Selective sparing of NADPH‐diaphorase neurons in neonatal hypoxia‐ischemia

1988 • 153 citations

Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil

1994 • 150 citations

DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat

1995 • 135 citations

Cold thoughts of death: the role of ICE proteases in neuronal cell death

1996 • 118 citations

Cloning and Expression of a Rat Brain Interleukin-1β-Converting Enzyme (ICE)-Related Protease (IRP) and Its Possible Role in Apoptosis of Cultured Cerebellar Granule Neurons

1997 • 92 citations

Mechanisms And Functions Of Cell Death

1991 • 77 citations

Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats

1997 • 76 citations

Effects of hypoxia‐ischemia on monoamine metabolism in the immature brain

1984 • 74 citations

Adenovirus-mediated over-expression of Interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats

1996 • 70 citations

Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.

1992 • 70 citations

Potential New Therapies for Perinatal Cerebral Hypoxia-Ischemia

1993 • 60 citations

Caspases: A treatment target for neurodegenerative disease?

1997 • 52 citations

Organization of the proximal, orbital segment of the infraorbital nerve at multiple intervals after axotomy at birth: A quantitative electron microscopic study in rat

1993 • 14 citations