A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain

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2001 • 133,517 citations

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1990 • 87,358 citations

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1990 • 2,029 citations

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1990 • 727 citations

Compilation and analysis of DNA sequences associated with apparent streptomycete promoters

1992 • 486 citations

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

1995 • 436 citations

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1995 • 245 citations

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1996 • 244 citations

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1992 • 240 citations

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1992 • 238 citations

Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate‐forming enzymes

1992 • 205 citations

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

1992 • 182 citations

Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack.

1991 • 162 citations

Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

1989 • 159 citations

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase

1996 • 142 citations

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin‐producing polyketide synthase from Saccharopolyspora erythraea

1992 • 137 citations

Physical map of the Streptomyces lividans 66 genome and comparison with that of the related strain Streptomyces coelicolor A3(2)

1993 • 137 citations

Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacteriumPseudomonas aureofaciens30–84

1995 • 132 citations

Cloning and Nucleotide Sequence of the Gene Responsible for Chlorination of Tetracycline

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1986 • 91 citations

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1994 • 81 citations

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Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid

1990 • 68 citations

A cDNA encoding 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Solanum tuberosum L.

1990 • 67 citations

The nucleotide sequence of the aroF gene of Escherichia coli and the amino acid sequence of the encoded protein, the tyrosine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

1984 • 52 citations

Cloning, primary structure and regulation of the ARO4 gene, encoding the tyrosine-inhibited 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae

1992 • 52 citations

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1993 • 45 citations

Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium Pseudomonas aureofaciens 30–84

1995 • 44 citations

The cyclohexane moiety of rapamycin is derived from shikimic acid inStreptomyces hygroscopicus

1993 • 44 citations

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1997 • 37 citations

Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253

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Cloning and Nucleotide Sequence of a Complementary DNA Encoding 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase from Tobacco

1991 • 31 citations

The Nature of the Starter Unit for the Rapamycin Polyketide Synthase

1996 • 30 citations

Evidence for a sex factor in Streptomyces erythreus

1985 • 25 citations

Cloning and Sequencing of a Second cDNA Encoding 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase from Solanum tuberosum L.

1992 • 23 citations