Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

A complementation analysis of the restriction and modification of DNA in Escherichia coli

1969 • 3,866 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

Rapid and efficient cosmid cloning

1981 • 1,897 citations

Cloning and Expression of the Tyrosinase Gene from Streptomyces antibioticus in Streptomyces lividans

1983 • 640 citations

Macrolide antibiotics. Chemistry, biology, and practice

1985 • 482 citations

Construction and characterisation of a series of multi-copy promoter-probe plasmid vectors for Streptomyces using the aminoglycoside phosphotransferase gene from Tn5 as indicator

1986 • 403 citations

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

1984 • 358 citations

Control Mechanisms in the Synthesis of Saturated Fatty Acids

1977 • 324 citations

Genetics and Molecular Biology of Industrial Microorganisms

1989 • 319 citations

Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)

1989 • 288 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction

1982 • 229 citations

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1989 • 226 citations

Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

1987 • 164 citations

Cloning and Expression in Streptomyces lividans of Clustered Erythromycin Biosynthesis Genes from Streptomyces erythreus

1986 • 127 citations

The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains

1986 • 126 citations

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

1987 • 123 citations

Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.

1988 • 121 citations

Genetic analysis of erythromycin production in Streptomyces erythreus

1985 • 110 citations

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea

1990 • 101 citations

INDUCIBLE ERYTHROMYCIN RESISTANCE IN BACTERIA

1984 • 63 citations

New antibiotics from genetically engineered actinomycetes. I. 2-norerythromycins, isolation and structural determinations.

1987 • 62 citations

Multigene families for anthracycline antibiotic production in Streptomyces peucetius.

1989 • 62 citations

Mutants Blocked in Antibiotic Synthesis

1978 • 56 citations

Studies on the Biosynthesis of the Erythromycins. II. Isolation and Structure of a Biosynthetic Intermediate, 6-Deoxyerythronolide B^*

1967 • 55 citations

Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus)

1989 • 49 citations

The use of a chromosome integration vector to map erythromycin resistance and production genes in Saccharopolyspora erythraea (Streptomyces erythraeus)

1988 • 47 citations

Site-specific integration in Saccharopolyspora erythraea and multisite integration in Streptomyces lividans of actinomycete plasmid pSE101

1988 • 43 citations

Expression of the macrolide-lincosamide-streptogramin-B-resistance methylase gene, ermE, from Streptomyces erythraeus in Escherichia coli results in N6-monomethylation and N6,N6-dimethylation of ribosomal RNA

1987 • 25 citations

A cryptic plasmid in the chloramphenicol-producing actinomycete,Streptomyces phaeochromogenes

1983 • 15 citations