Structural Organization of A Multifunctional Polyketide Synthase Involved in the Biosynthesis of the Macrolide Immunosuppressant FK506

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

1991 • 883 citations

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1990 • 727 citations

MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

1990 • 674 citations

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1990 • 611 citations

The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

1994 • 585 citations

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

1995 • 436 citations

Developments in Industrial Microbiology

1960 • 423 citations

POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics

1993 • 369 citations

The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulum

1990 • 301 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases

1995 • 245 citations

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase

1996 • 244 citations

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1992 • 238 citations

Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.

1992 • 229 citations

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1989 • 226 citations

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

1992 • 182 citations

6‐Deoxyerythronolide‐B synthase 2 from Saccharopolyspora erythraea

1992 • 174 citations

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

1987 • 123 citations

Molecular cloning and sequencing of the gene for mycocerosic acid synthase, a novel fatty acid elongating multifunctional enzyme, from Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin.

1992 • 102 citations

Structural organization of the multifunctional animal fatty‐acid synthase

1991 • 99 citations

Fatty acid synthase — an example of protein evolution by gene fusion

1984 • 95 citations

Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function.

1993 • 84 citations

A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes

1995 • 83 citations

Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

1994 • 81 citations

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

1996 • 81 citations

Integrative vectors for heterologous gene expression in Streptomyces spp.

1995 • 78 citations

Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid

1990 • 68 citations

Vectors for generating nested deletions and facilitating subcloning G + C-rich DNA between Escherichia coli and Streptomyces sp.

1992 • 10 citations