Models of arthritis and the search for anti-arthritic drugs

Immunochemical quantitation of antigens by single radial immunodiffusion

1965 • 9,369 citations

Protides of the Biological Fluids

1969 • 1,623 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

Immunisation against heterologous type II collagen induces arthritis in mice

1980 • 1,025 citations

Control of vascular permeability by polymorphonuclear leukocytes in inflammation

1981 • 850 citations

Development of Arthritis, Periarthritis and Periostitis in Rats Given Adjuvants.

1956 • 847 citations

Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

1977 • 710 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

The Immunopathology of Joint Inflammation in Rheumatoid Arthritis

1973 • 561 citations

Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. I. General clinical and pathologic characteristics and some modifying factors

1959 • 421 citations

The production of arthritis in rabbits by an immunological reaction to fibrin.

1962 • 389 citations

Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.

1960 • 336 citations

Antigen‐induced arthritis in mice

1977 • 334 citations

Collagen heterogeneity in human cartilage: Identification of several new collagen chains

1979 • 324 citations

1 A Treatise on the Blood, Inflammation, and Gun-Shot Wounds

1963 • 290 citations

Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes.

1977 • 273 citations

Mechanisms of bone destruction in the development of skeletal metastases

1976 • 273 citations

Humoral and Cellular Sensitivity to Collagen in Type II Collagen-Induced Arthritis in Rats

1978 • 259 citations

Collagen arthritis as a relevant model for rheumatoid arthritis. evidence pro and con

1982 • 256 citations

Cellular Sensitivity to Collagen in Rheumatoid Arthritis

1978 • 211 citations

Treatment of Intractable Rheumatoid Arthritis with Total Lymphoid Irradiation

1981 • 210 citations

Macrophage Activation by Mycobacterial Water Soluble Compounds and Synthetic Muramyl Dipeptide

1979 • 209 citations

Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis

1976 • 205 citations

THE PATHOGENESIS OF CHRONIC INFLAMMATION IN EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS

1972 • 203 citations

Passive Transfer by Cells of Type II Collagen-Induced Arthritis in Rats

1978 • 202 citations

STUDIES OF ARTHRITIS AND OTHER LESIONS INDUCED IN RATS BY INJECTION OF MYCOBACTERIAL ADJUVANT

1961 • 202 citations

Studies of Arthritis and Other Lesions Induced in Rats by Injection of Mycobacterial Adjuvant

1960 • 188 citations

Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins

1976 • 183 citations

The pharmacology of benoxaprofen (2-[4-chlorophenyl]-α-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with anti-inflammatory activity apparently unrelated to inhibition of prostaglandin synthesis

1977 • 180 citations

Immunogenetic control of experimental type ii collagen‐induced arthritis

1981 • 178 citations

Clinical and Immunologic Effects of Fractionated Total Lymphoid Irradiation in Refractory Rheumatoid Arthritis

1981 • 167 citations

Experimental joint disease

1963 • 154 citations

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

1977 • 149 citations

Adjuvant polyarthritis iv. induction by a synthetic adjuvant: immunologic, histopathologic, and other studies

1980 • 146 citations

Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.

1975 • 144 citations

Monocytes regulate osteoclast-activating factor production by releasing prostaglandins.

1979 • 138 citations

The chronicity of inflammation and its significance in rheumatoid arthritis.

1968 • 135 citations

Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint.

1971 • 134 citations

Different HLA-D associations in adult and juvenile rheumatoid arthritis.

1979 • 132 citations

Passive Transfer of Adjuvant Arthritis in Rats with Living Lymphoid Cells of Sensitized Donors

1963 • 129 citations

The Effects of Some Anti-inflammatory Drugs on the Acute-phase Proteins in Rheumatoid Arthritis

1973 • 128 citations

Treatment of adjuvant arthritis in rats with anti‐inflammatory drugs

1966 • 119 citations

The incidence and antigenic specificity of antibodies against denatured human collagen in rheumatoid arthritis

1974 • 116 citations

Native Type II Collagen‐Induced Arthritis in the Rat

1981 • 115 citations

SUPPRESSION OF ADJUVANT DISEASE IN THE RAT BY HETEROLOGOUS ANTILYMPHOCYTE GLOBULIN

1968 • 109 citations

Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

1974 • 108 citations

Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases

1980 • 106 citations

Morphologic demonstration of two stages in the development of type II collagen-induced arthritis.

1982 • 106 citations

The Assessment of Rheumatoid Arthritis<subtitle>A STUDY BASED ON MEASUREMENTS OF THE SERUM ACUTE-PHASE REACTANTS</subtitle>

1972 • 103 citations

Comparative bioassay of drugs in adjuvant‐induced arthritis in rats: Flufenamic acid, mefenamic acid, and phenylbutazone

1969 • 100 citations

Comparative effect of antirheumatic drugs on adjuvant-induced polyarthritis in rats.

1966 • 99 citations

Adjuvant-induced polyarthritis in rats: biologic and histologic background.

1965 • 94 citations

Incidence of serum antibodies to native type I and type II collagens in patients with inflammatory arthritis.

1980 • 91 citations

Effect of Prostaglandin E2 on Adjuvant Arthritis

1969 • 91 citations

Effect of Psychological Stress on the Induction of Arthritis in Rats

1980 • 88 citations

Mode of Action of Anti-Inflammatory Agents Which are Prostaglandin Synthetase Inhibitors

1979 • 87 citations

Structural Requirements for Arthritogenicity of Peptidoglycans from Staphylococcus Aureus and Lactobacillus Plantarum and Analogous Synthetic Compounds

1976 • 87 citations

Antigenicity of Collagen and its Application in the Serological Investigation of Rheumatoid Arthritis Sera

1963 • 81 citations

LEUKOCYTIC PYROGEN: A MAJOR MEDIATOR OF THE ACUTE PHASE REACTION

1982 • 76 citations

Effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migration

1979 • 76 citations

1 Immunopharmacology of Gold

1982 • 75 citations

Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.

1976 • 75 citations

Collagen-induced arthritis in the rat: modification of immune and arthritic responses by free collagen and immune anti-collagen antiserum.

1981 • 75 citations

Chemical changes in adjuvant-induced polyarthritis of rats.

1965 • 73 citations

STUDIES ON TYPE II COLLAGEN–INDUCED POLYARTHRITIS IN RATS. Effect of Antiinflammatory and Antirheumatic Agents

1981 • 73 citations

Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.

1980 • 73 citations

THE ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITIS

1974 • 71 citations

Role of Lymph Nodes in Adjuvant-Induced Arthritis in Rats

1964 • 65 citations

Do drugs change the course of rheumatoid arthritis?

1980 • 65 citations

Studies on antigen-induced arthritis in mice. III. Cell and serum transfer experiments.

1977 • 63 citations

Studies on adjuvant‐induced polyarthritis in rats. I. Adjuvant composition, route of injection, and removal of depot site

1962 • 63 citations

Evaluation for Antiinflammatory Activity

1974 • 63 citations

The occurrence of antibodies to collagen in synovial fluids

1975 • 63 citations

Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan.

1981 • 60 citations

New model of a synthetic adjuvant, N-acetylmuramyl-L-alanyl-D-isoglutamine- induced arthritis: clinical and histologic studies in athymic nude and euthymic rats.

1982 • 60 citations

Experimental Models of Arthritis in Animals as Screening Tests for Drugs to Treat Arthritis in Man

1979 • 58 citations

Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial disaccharide peptides related to different oil vehicles and their composition

1980 • 58 citations

Adjuvant Disease in Rats: Biochemical Criteria for Distinguishing Several Phases of Inflammation and Arthritis

1974 • 53 citations

Serum protein changes in rats with arthritis induced by mycobacterial adjuvant

1964 • 51 citations

DRUG TREATMENT OF RHEUMATOID ARTHRITIS

1975 • 50 citations

MYCOBACTERIAL ADJUVANT PERIARTHRITIS IN RODENTS AND ITS MODIFICATION BY ANTIINFLAMMATORY AGENTS

1966 • 50 citations

Further Immunologic Studies of Adjuvant Disease in the Rat

1963 • 50 citations

The role of the acute phase reaction in inflammation

1976 • 49 citations

Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice.

1977 • 48 citations

Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls

1977 • 47 citations

Lipids, Lipoproteins, and Drugs

1975 • 47 citations

The role of collagen autoimmunity in animal models and human diseases.

1982 • 46 citations

The systemic response to inflammation

1968 • 46 citations

Comparative Effects of Some Immunosuppressive and Anti-Inflammatory Drugs on Allergic Encephalomyelitis and Adjuvant Arthritis

1967 • 44 citations

Studies of the Mechanism whereby Adjuvant Disease is Suppressed in Rats Pretreated with Mycobacteria

1967 • 44 citations

Gold does not alter the arthritic, humoral, or cellular responses in rats with type ii collagen‐i nduced arthritis

1980 • 44 citations

Adjuvant-induced arthritis: effects of certain drugs on incidence, clinical severity, and biochemical changes.

1966 • 44 citations

Experimental immune synovitis in the rabbit. Relative roles of cell mediated and humoral immunity

1974 • 42 citations

Studies on Antigen-Induced Arthritis in Mice

1977 • 42 citations

Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.

1975 • 42 citations

Action of gold salts in some inflammatory and immunological models

1980 • 42 citations

Treatment of primary gout: The present status (The W. Paul Holbrook Memorial Lecture)

1965 • 41 citations

Investigations on the influence of Cyclophosphamide, gold sodium thiomalate andd-penicillamine on nystatin oedema and adjuvant arthritis

1975 • 41 citations

Assessment in Rheumatoid Arthritis

1968 • 41 citations

A STUDY OF ADJUVANT‐INDUCED POLYARTHRITIS IN THE RAT WITH SPECIAL REFERENCE TO ASSOCIATED IMMUNOLOGICAL PHENOMENA*

1969 • 41 citations

Effect of cyclophosphamide, hydrocortisone, and levamisole on collagen‐induced arthritis in rats

1981 • 40 citations

Studies on Antigen-Induced Arthritis in Mice

1977 • 40 citations

Lymphocyte transformation to denatured type i collagen and b lymphocyte alloantigens in rheumatoid arthritis

1980 • 40 citations

Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

1971 • 39 citations

Light and electron microscope studies in carragheenin, adjuvant, and tuberculin-induced arthris.

1969 • 39 citations

Experimental Arthritis Associated with Auto-Immunization to Inflammatory Exudates

1966 • 39 citations

N-Carboxyphenyl)-4-chloroanthranilic acid disodium salt: a novel anti-arthritic agent without anti-inflammatory and immunosuppressive activities

1977 • 35 citations

The effect of drugs in established rabbit monoarticular arthritis

1977 • 35 citations

Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease

1972 • 34 citations

Suppression of rat adjuvant disease by cyclophosphamide pretreatment: evidence for an antibody mediated component in the pathogenesis of the disease.

1978 • 34 citations

Fibrinogen and experimental inflammation

1969 • 33 citations

LYMPHATIC DRAINAGE AND ADJUVANT-INDUCED ARTHRITIS IN RATS.

1964 • 33 citations

The anti-inflammatory properties of isoxicam (4-hydroxy-2-methyl-N-[5-Methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide])

1975 • 33 citations

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

1976 • 32 citations

The effects of oral D-penicillamine treatment on experimental arthritis and the associated immune response in rabbits. II. The effects on cellular parameters.

1978 • 31 citations

The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis

1980 • 31 citations

N-(2-Carboxyphenyl)-4-chloroanthranilic acid disodium salt: prevention of autoimmune kidney disease in NZB/NZW F1 hybrid mice

1978 • 31 citations

Action of anti-inflammatory agents upon blood and histopathologic changes induced by periarthritis in rats

1966 • 30 citations

Influence of gold salts on adjuvant arthritis in the rat.

1968 • 30 citations

Adjuvant arthritis in the rat: Distribution of fluorescent material after footpad injection of rhodamine-labelled tubercle bacilli

1976 • 27 citations

Persistence of antigen in nonarthritic joints.

1975 • 26 citations

Serum protein alterations in adjuvant-induced arthritis

1968 • 26 citations

Adjuvant Arthritis Induced by Corynebacterium rubrum

1970 • 25 citations

Effect of Gold Preparations on the Development and Passive Transfer of Experimental Allergic Encephalomyelitis in Rats

1972 • 25 citations

Contribution to the study of the structure of adjuvant active waxes D from mycobacteria: Isolation of a peptidoglycan

1968 • 25 citations

Applied Drug Therapy of the Rheumatic Diseases

1983 • 24 citations

Inhibition of the primary lesion of adjuvant. induced polyarthritis in rats (18-hour arthritis test) for specific detection of clinically effective anti-arthritic drugs.

1975 • 24 citations

Rheumatoid arthritis: effects of a new agent (ICI 55 897) on serum acute phase proteins and the erythrocyte sedimentation rate.

1980 • 23 citations

Effects of Oral Cysteine, Penicillamine and N-Acetyl-penicillamine on Adjuvant Arthritis in Rats

1968 • 23 citations

Stimulation of collagenase secretion from rheumatoid synovial tissue by human collagen peptides.

1982 • 23 citations

Pharmacology of a new analgesic, antipyretic, and anti-inflammatory agent, 4-allyloxy-3-chlorophenylacetic acid.

1970 • 23 citations

Persistence of antigen in rabbit synovial membrane.

1971 • 22 citations

The effects of oral D-penicillamine treatment on experimental arthritis and the associated immune response in rabbits.

1978 • 21 citations

Periarthritis produced in rats with Freund's adjuvants

1960 • 21 citations

Effects of prednisolone in an experimental model of arthritis in the rabbit.

1971 • 21 citations

Stimulation of collagenase secretion from rheumatoid synovial tissue by human collagen peptides.

1982 • 20 citations

Adjuvant‐Polyarthritogenicity of Cell Walls of Mycobacteria, Nocardia and Corynebacteria

1972 • 20 citations

Genetic control of adjuvant-induced arthritis in rats

1971 • 20 citations

Alclofenac and D-penicillamine. Comparative trial in rheumatoid arthritis.

1978 • 19 citations

Correlation of adjuvant activity and chemical structure of mycobacterial wax D fractions: The importance of amino sugars

1964 • 18 citations

α-2-GP response in adjuvant-induced polyarthritis: An immunoassay for anti-inflammatory activity

1967 • 18 citations

Antirheumatic activity of fenclofenac.

1980 • 18 citations

Breeding experiments on the frequency of adjuvant arthritis in the rat.

1973 • 17 citations

A biochemical comparison of alclofenac and D-penicillamine in rheumatoid arthritis.

1980 • 17 citations

The Adjuvant Arthritic Rat: Inflammatory Parameters during Development and Regression of Gross Lesions

1968 • 17 citations

Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.

1977 • 17 citations

Immunopharmacologic effects of cycloleucine.

1972 • 16 citations

The prophylactic and therapeutic effects of gold sodium thiomalate against adjuvant-induced polyarthritis in rats

1973 • 15 citations

Inflammation: Mechanisms and Treatment

1980 • 15 citations

Chronic immune synovitis in rabbits. II. Modulation by anti-inflammatory and anti-rheumatic agents

1981 • 15 citations

Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.

1979 • 14 citations

Immunosuppression by fractionated total lymphoid irradiation in collagen arthritis

1982 • 14 citations

ANTI‐INFLAMMATORY AND RELATED PROPERTIES OF 4‐(P‐BIPHENYLYL)‐3‐HYDROXYBUTYRIC ACID

1968 • 13 citations

Fenoprofen and Benoxaprofen

1979 • 13 citations

Reevaluation of Inguinal Lymph Node Injection for Production of Adjuvant Arthritis in the Rat

1976 • 12 citations

Blood changes in experimental arthritis in two types of genetically different rats

1973 • 11 citations

Recent developments in disease-modifying antirheumatic drugs

1980 • 11 citations

Evaluation for Immunosuppressive and Antiallergic Activity

1974 • 11 citations

Potential Antiarthritic Agents I: Benzoylacetonitriles

1979 • 11 citations

Cytostats with Effects in Chronic Inflammation

1979 • 10 citations

Use of the rotarod in determining grip strength in rats with adjuvant-induced arthritis.

1968 • 10 citations

Anti-rheumatic drugs

1981 • 10 citations

Resistance and susceptibility to the induction of rat adjuvant disease. Diverging susceptibility and severity achieved by selective breeding.

1979 • 9 citations

Adjuvant Arthritis in Mice and Hamsters

1971 • 9 citations

Is local antigen persistence responsible for the chronicity of the experimental immune arthritis of the rabbit?

1976 • 8 citations

Nonsteroidal acidic anti-inflammatory agents: Do they constitute a single drug class?

1979 • 7 citations

Effects of benoxaprofen on the inflammatory, humoral and cellular components of type II collagen-induced arthritis in rats.

1982 • 7 citations

Effect of fenclofenac on prostaglandin production in carageenin air bleb exudates in rats

1978 • 7 citations

Aspects of resorption and formation of connective tissue during chronic inflammation in rheumatoid arthritis.

1982 • 6 citations

Experimental and Clinical Evaluation of Two “Atromid-S” Analogues in Relation to their Differential Modes of Action

1975 • 5 citations

Effect of phospholipids on histamine release.

1972 • 5 citations

Study of the mode of cyclophosphamide action on the rabbit arthritis according to Glynn's model.

1975 • 3 citations

Effect of ICI 55897 (Clozic), indomethacin and dexamethasone on collagenase and prostaglandin production by cultured rheumatoid synovial tissue (Abstract)

1980 • 2 citations

Resistance of rats to carrageenan and to adjuvant-induced arthritis

1972 • 2 citations