Experimental Models of Arthritis in Animals as Screening Tests for Drugs to Treat Arthritis in Man

Immunochemical quantitation of antigens by single radial immunodiffusion

1965 • 9,369 citations

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

1962 • 5,670 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

Protides of the Biological Fluids

1969 • 1,623 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Development of Arthritis, Periarthritis and Periostitis in Rats Given Adjuvants.

1956 • 847 citations

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT

1963 • 523 citations

Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. I. General clinical and pathologic characteristics and some modifying factors

1959 • 421 citations

Acute-Phase Reactants

1974 • 398 citations

The production of arthritis in rabbits by an immunological reaction to fibrin.

1962 • 389 citations

Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.

1960 • 336 citations

Antigen‐induced arthritis in mice

1977 • 334 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

THE PATHOGENESIS OF CHRONIC INFLAMMATION IN EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS

1972 • 203 citations

STUDIES OF ARTHRITIS AND OTHER LESIONS INDUCED IN RATS BY INJECTION OF MYCOBACTERIAL ADJUVANT

1961 • 202 citations

An Anti-Inflammatory Peptide from Bee Venom

1973 • 194 citations

Studies of Arthritis and Other Lesions Induced in Rats by Injection of Mycobacterial Adjuvant

1960 • 188 citations

PASSIVE TRANSFER OF ADJUVANT ARTHRITIS BY LYMPH NODE OR SPLEEN CELLS

1964 • 188 citations

THE LYMPHATIC PARTICIPATION IN HUMAN CUTANEOUS PHENOMENA

1933 • 155 citations

Experimental joint disease

1963 • 154 citations

Displacement of One Drug by Another from Carrier or Receptor Sites

1965 • 152 citations

Capacity of Mycobacterial Wax D and its Subfractions to Induce Adjuvant Arthritis in Rats

1969 • 150 citations

Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.

1975 • 144 citations

STUDIES ON LYSOSOMES

1964 • 140 citations

The chronicity of inflammation and its significance in rheumatoid arthritis.

1968 • 135 citations

Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters.

1971 • 134 citations

Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint.

1971 • 134 citations

Passive Transfer of Adjuvant Arthritis in Rats with Living Lymphoid Cells of Sensitized Donors

1963 • 129 citations

The Effects of Some Anti-inflammatory Drugs on the Acute-phase Proteins in Rheumatoid Arthritis

1973 • 128 citations

The Pharmacology of Inflammation

1986 • 121 citations

Treatment of adjuvant arthritis in rats with anti‐inflammatory drugs

1966 • 119 citations

Inflammation Biochemistry and Drug Interaction

1971 • 115 citations

SUPPRESSION OF ADJUVANT DISEASE IN THE RAT BY HETEROLOGOUS ANTILYMPHOCYTE GLOBULIN

1968 • 109 citations

Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

1974 • 108 citations

The Experimental Production of Arthritis: A Review

1960 • 107 citations

The Assessment of Rheumatoid Arthritis<subtitle>A STUDY BASED ON MEASUREMENTS OF THE SERUM ACUTE-PHASE REACTANTS</subtitle>

1972 • 103 citations

Comparative bioassay of drugs in adjuvant‐induced arthritis in rats: Flufenamic acid, mefenamic acid, and phenylbutazone

1969 • 100 citations

Comparative effect of antirheumatic drugs on adjuvant-induced polyarthritis in rats.

1966 • 99 citations

Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics

1971 • 98 citations

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins

1973 • 96 citations

Adjuvant-induced polyarthritis in rats: biologic and histologic background.

1965 • 94 citations

Effect of Prostaglandin E2 on Adjuvant Arthritis

1969 • 91 citations

The Pharmacology of Inflammation.

1969 • 90 citations

Structural Requirements for Arthritogenicity of Peptidoglycans from Staphylococcus Aureus and Lactobacillus Plantarum and Analogous Synthetic Compounds

1976 • 87 citations

Lysosomal enzyme activity in rats with adjuvant-induced arthritis.

1970 • 85 citations

Complement in acute inflammation

1969 • 83 citations

The anti‐inflammatory effect of some immunosuppressive agents

1969 • 82 citations

Sparing effect of neurological deficit and trauma on the course of adjuvant arthritis in the rat.

1965 • 81 citations

Nonsteroid Anti-Inflammatory Agents

1973 • 77 citations

Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.

1976 • 75 citations

The Use of a Standardized Adjuvant Arthritis Assay to Differentiate Between Anti-inflammatory and Immunosuppressive Agents

1971 • 74 citations

The effects of adjuvant-induced arthritis on the liver metabolism of drugs in rats

1970 • 73 citations

Chemical changes in adjuvant-induced polyarthritis of rats.

1965 • 73 citations

STUDIES ON LYSOSOMES. VII. ACUTE AND CHRONIC ARTHRITIS PRODUCED BY INTRA-ARTICULAR INJECTIONS OF STREPTOLYSIN S IN RABBITS.

1965 • 71 citations

THE ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITIS

1974 • 71 citations

SUPPRESSION OF EXPERIMENTALLY INDUCED POLYARTHRITIS IN THE RAT BY HETEROLOGOUS ANTI-LYMPHOCYTE SERUM

1966 • 70 citations

Role of T lymphocytes in adjuvant arthritis. II. Different subpopulations of T lymphocytes functioning in the development of the disease.

1978 • 66 citations

Role of Lymph Nodes in Adjuvant-Induced Arthritis in Rats

1964 • 65 citations

Evaluation for Antiinflammatory Activity

1974 • 63 citations

Role of T lymphocytes in adjuvant arthritis. I. Evidence for the regulatory function of thymus-derived cells in the induction of the disease.

1976 • 63 citations

Studies on adjuvant‐induced polyarthritis in rats. II. Histogenesis of joint and visceral lesions

1963 • 63 citations

Studies on antigen-induced arthritis in mice. III. Cell and serum transfer experiments.

1977 • 63 citations

Studies on adjuvant‐induced polyarthritis in rats. I. Adjuvant composition, route of injection, and removal of depot site

1962 • 63 citations

Experimental arthritis produced by injection of mediators of delayed hypersensitivity

1974 • 61 citations

Acute Immunologic Arthritis in Rabbits

1972 • 58 citations

Prostaglandin e₁ (pge₁) suppression of adjuvant arthritis histopathology

1973 • 57 citations

Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism

1973 • 55 citations

Studies on adjuvant‐induced polyarthritis in rats. III. The effect of “immunosuppressive agents” on arthritis and tuberculin hypersensitivity

1964 • 53 citations

Adjuvant Disease in Rats: Biochemical Criteria for Distinguishing Several Phases of Inflammation and Arthritis

1974 • 53 citations

Experimental Arthritis in Mice with Mycoplasma pulmonis

1969 • 52 citations

Failure of oral D-penicillamine to modify adjuvant arthritis or immune response in the rat.

1972 • 51 citations

Adjuvant-induced arthritis and drug-metabolizing enzymes

1976 • 51 citations

Serum protein changes in rats with arthritis induced by mycobacterial adjuvant

1964 • 51 citations

DRUG TREATMENT OF RHEUMATOID ARTHRITIS

1975 • 50 citations

MYCOBACTERIAL ADJUVANT PERIARTHRITIS IN RODENTS AND ITS MODIFICATION BY ANTIINFLAMMATORY AGENTS

1966 • 50 citations

Further Immunologic Studies of Adjuvant Disease in the Rat

1963 • 50 citations

The role of the acute phase reaction in inflammation

1976 • 49 citations

A comparative study of the Lewis and Sprague Dawley rat in adjuvant arthritis.

1970 • 49 citations

Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice.

1977 • 48 citations

Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls

1977 • 47 citations

The systemic response to inflammation

1968 • 46 citations

THE PATHOGENESIS OF ADJUVANT DISEASE IN THE RAT. I. A HISTOLOGIC STUDY OF EARLY LESIONS IN THE JOINTS AND SKIN.

1964 • 46 citations

The mast cell in early rat adjuvant arthritis.

1971 • 45 citations

Polyarthritis Induced in the Rat with Cell Walls from Several Bacteria and Two Streptomyces Species

1973 • 45 citations

Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis

1972 • 45 citations

Comparative Effects of Some Immunosuppressive and Anti-Inflammatory Drugs on Allergic Encephalomyelitis and Adjuvant Arthritis

1967 • 44 citations

Adjuvant-Induced Arthritis in Rats I. Temporal Relationship of Physiological, Biochemical, and Hematological Parameters

1971 • 44 citations

Adjuvant-induced arthritis: effects of certain drugs on incidence, clinical severity, and biochemical changes.

1966 • 44 citations

Studies of the Mechanism whereby Adjuvant Disease is Suppressed in Rats Pretreated with Mycobacteria

1967 • 44 citations

Differences in the Severity of Adjuvant Arthritis in Four Strains of Rats

1969 • 43 citations

SK&F 36914--an agent for oral chrysotherapy.

1972 • 42 citations

Studies on Antigen-Induced Arthritis in Mice

1977 • 42 citations

Experimental immune synovitis in the rabbit. Relative roles of cell mediated and humoral immunity

1974 • 42 citations

Antiarthritic and Antiinflammatory Effects of Certain Prostaglandins

1972 • 42 citations

Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.

1975 • 42 citations

A STUDY OF ADJUVANT‐INDUCED POLYARTHRITIS IN THE RAT WITH SPECIAL REFERENCE TO ASSOCIATED IMMUNOLOGICAL PHENOMENA*

1969 • 41 citations

Assessment in Rheumatoid Arthritis

1968 • 41 citations

Effect of bee venom on experimental arthritis.

1973 • 40 citations

Studies on Antigen-Induced Arthritis in Mice

1977 • 40 citations

Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

1971 • 39 citations

Experimental Arthritis Associated with Auto-Immunization to Inflammatory Exudates

1966 • 39 citations

Light and electron microscope studies in carragheenin, adjuvant, and tuberculin-induced arthris.

1969 • 39 citations

Inhibition by 6-Mercaptopurine of Polyarthritis induced by Freund's Adjuvant

1964 • 35 citations

Evidence for an endogenous antigen in the adjuvant arthritic rat

1973 • 34 citations

Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease

1972 • 34 citations

Plasma inflammation units: An objective method for investigating effects of drugs on experimental inflammation

1966 • 34 citations

An X-ray analysis of adjuvant arthritis in the rat. The effect of prednisolone and indomethacin

1977 • 34 citations

Impaired Drug Metabolism in Rats Associated with Acute Inflammation: A Possible Assay for Anti-injury Agents

1974 • 33 citations

Fibrinogen and experimental inflammation

1969 • 33 citations

LYMPHATIC DRAINAGE AND ADJUVANT-INDUCED ARTHRITIS IN RATS.

1964 • 33 citations

THE PRIMARY CAUSE OF RHEUMATOID ARTHRITIS IS AN INFECTION—THE INFECTIOUS AGENT EXISTS IN MILK

1972 • 33 citations

The anti-inflammatory properties of isoxicam (4-hydroxy-2-methyl-N-[5-Methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide])

1975 • 33 citations

Arthritis induced by Filipin in rabbits

1967 • 32 citations

Role of the Liver in Inflammation

1971 • 32 citations

Arthritis of mice induced by Mycoplasma arthritidis. Humoral antibody and lymphocyte responses of CBA mice.

1976 • 30 citations

Action of anti-inflammatory agents upon blood and histopathologic changes induced by periarthritis in rats

1966 • 30 citations

Influence of gold salts on adjuvant arthritis in the rat.

1968 • 30 citations

Chemotherapy of experimental allergic encephalomyelitis (EAE).

1969 • 29 citations

Anti-lymphocytic antibody and autoimmune disease: a review.

1969 • 29 citations

Chronic Self-Perpetuating Arthritis Induced in Rabbits by a Cell-Free Extract of Group A Streptococci

1973 • 29 citations

Experimental immune inflammation in the synovial membrane. I. The immunological mechanism.

1968 • 29 citations

Arthritis in Mice Due to Infection with Mycoplasma pulmonis, I. Clinical and Microbiologic Features

1973 • 29 citations

Reproducible polyarthritis in rats caused by Mycoplasma arthritidis.

1971 • 28 citations

A comparison of immunosuppressive and anti-inflammatory agents in the rat.

1971 • 28 citations

Role of T Lymphocytes in Adjuvant Arthritis

1976 • 27 citations

Adjuvant arthritis in the rat: Distribution of fluorescent material after footpad injection of rhodamine-labelled tubercle bacilli

1976 • 27 citations

Persistence of antigen in nonarthritic joints.

1975 • 26 citations

Induction of Adjuvant Arthritis in the Rat by Various Bacterial Cell Walls and their Water-Soluble Components

1976 • 26 citations

Serum protein alterations in adjuvant-induced arthritis

1968 • 26 citations

Induction of proliferative synovitis in rabbits by intra‐articular injection of immune complexes

1967 • 25 citations

Adjuvant Arthritis Induced by Corynebacterium rubrum

1970 • 25 citations

Action of antiinflammatory drugs on the lysozyme activity and "turbidity" of serum from rats with adjuvant arthritis or endocrine deficiency.

1969 • 25 citations

Contribution to the study of the structure of adjuvant active waxes D from mycobacteria: Isolation of a peptidoglycan

1968 • 25 citations

Prolonged pentobarbital sleeping time in adjuvant-induced polyarthritic rats.

1974 • 24 citations

Effects of Oral Cysteine, Penicillamine and N-Acetyl-penicillamine on Adjuvant Arthritis in Rats

1968 • 23 citations

Protection of Rats against Adjuvant Arthritis by Bacterial Lipopolysaccharides

1962 • 23 citations

Two Anti-inflammatory Components in Antilymphocytic Serum

1970 • 22 citations

Persistence of antigen in rabbit synovial membrane.

1971 • 22 citations

Separation of Anti-inflammatory and Immunosuppressive Activities in Heterologous Antilymphocyte Serum

1969 • 22 citations

Periarthritis produced in rats with Freund's adjuvants

1960 • 21 citations

Effects of prednisolone in an experimental model of arthritis in the rabbit.

1971 • 21 citations

Effect of Sensitization to BSA on Adjuvant Disease in Normal and Neonatally Thymectomized Rats.

1965 • 20 citations

Abnormal drug metabolism in rats after an inflammatory insult

1973 • 20 citations

Suppression of adjuvant arthritis by estrone in adrenalectomized and ovariectomized rats

1967 • 20 citations

Chronic arthritis produced by streptococcal L‐forms

1969 • 20 citations

Adjuvant‐Polyarthritogenicity of Cell Walls of Mycobacteria, Nocardia and Corynebacteria

1972 • 20 citations

Genetic control of adjuvant-induced arthritis in rats

1971 • 20 citations

Adjuvant arthritis in the rat. Effect of intraperitoneal injections of either whole dead mycobacteria or tuberculin.

1970 • 19 citations

Abnormal Sulfhydryl-Disulfide Interchange in Serum of Rats with Adjuvant Arthritis: Correction by Anti-inflammatory Agents

1969 • 19 citations

Correlation of adjuvant activity and chemical structure of mycobacterial wax D fractions: The importance of amino sugars

1964 • 18 citations

Arthritis produced by intra‐articular injections of streptolysin S in rabbits

1966 • 18 citations

α-2-GP response in adjuvant-induced polyarthritis: An immunoassay for anti-inflammatory activity

1967 • 18 citations

Effects of salmon calcitonin and combination drug therapy on rat adjuvant arthritis

1974 • 18 citations

The Adjuvant Arthritic Rat: Inflammatory Parameters during Development and Regression of Gross Lesions

1968 • 17 citations

Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.

1977 • 17 citations

Experimental viral arthritis induced with herpes simplex

1973 • 16 citations

Experimental immune inflammation in the synovial membrane. II. The origin and local activity of inflammatory cells.

1969 • 16 citations

Effect of hepatic injury on adjuvant arthritis.

1973 • 16 citations

Immunopharmacologic effects of cycloleucine.

1972 • 16 citations

The prophylactic and therapeutic effects of gold sodium thiomalate against adjuvant-induced polyarthritis in rats

1973 • 15 citations

Effects of Topical Hydrocortisone and Acetylsalicylic Acid on the Primary Lesion of Adjuvant-Induced Arthritis

1971 • 15 citations

Inhibition of adjuvant arthritis by protein antigens. I. Inhibitory capacities and dose relationships of different proteins.

1969 • 15 citations

Cis-dichlorodiammineplatinum (II): Suppression of adjuvant-induced arthritis in rats

1974 • 14 citations

ANTI‐INFLAMMATORY AND RELATED PROPERTIES OF 4‐(P‐BIPHENYLYL)‐3‐HYDROXYBUTYRIC ACID

1968 • 13 citations

The histochemical demonstration of hydrolytic enzymes in adjuvant-induced arthritis in rats

1974 • 13 citations

Lysosomes as mediators of parenchymal lesions in adjuvant‐induced arthritis in rats

1972 • 12 citations

Reevaluation of Inguinal Lymph Node Injection for Production of Adjuvant Arthritis in the Rat

1976 • 12 citations

Protease and antiprotease levels in blood of arthritic rats.

1977 • 12 citations

Blood changes in experimental arthritis in two types of genetically different rats

1973 • 11 citations

Histochemical investigation of adjuvant‐induced arthritis

1976 • 11 citations

Experimental Arthritis in Thymectomized Rats with an Impaired Humoral Immune Response

1973 • 11 citations

Treatment of adjuvant arthritis in rats with the histidine decarboxylase inhibitor hypostamine

1969 • 11 citations

A comparison of the systemic anti-inflammatory activity of three different irritants in the rat.

1971 • 11 citations

The effect ofɛ-aminocaproic acid on adjuvant arthritis in rats

1964 • 11 citations

Evaluation for Immunosuppressive and Antiallergic Activity

1974 • 11 citations

Inhibition of adjuvant arthritis by histamine.

1976 • 11 citations

Hematologic Changes in Chronic Arthritis of Mice Induced by Mycoplasma arthritidis

1975 • 10 citations

Adjuvant Arthritis in T Lymphocyte Depleted Rats

1976 • 10 citations

Use of the rotarod in determining grip strength in rats with adjuvant-induced arthritis.

1968 • 10 citations

Influence of Thyroidectomy and Thyroid Hormones on Adjuvant Arthritis in Rats

1970 • 10 citations

Immunosuppressive activity of 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776).

1968 • 10 citations

The effects of a human plasma fraction on adjuvant arthritis and granuloma pellet reactions in the rat

1974 • 9 citations

Prophylactic effects of cyclophosphamide in adjuvant-induced arthritis.

1970 • 9 citations

Effect of duration of administration of cyclophosphamide and steroidal anti-inflammatory drugs on the severity of polyarthritis.

1971 • 9 citations

Suppressant effect of procarbazine and its comparison with anti-lymphocyte serum in adjuvant-induced polyarthritis in rats.

1970 • 9 citations

An Active Agent From Rheumatoid Arthritis Synovial Tissue

1972 • 9 citations

Adjuvant Arthritis in Mice and Hamsters

1971 • 9 citations

Effects of Antihistamine-Epinephrine Combinations on Adjuvant Arthritis in Rats

1973 • 8 citations

The effect of dried mussel extract on an induced polyarthritis in rats.

1975 • 8 citations

Suppression of an “adjuvant arthritis” in alloxan-diabetic rats

1965 • 8 citations

Standardisation of arthritogenic adjuvants for evaluating anti-inflammatory and immunosuppressant drugs

1974 • 8 citations

Adjuvant Disease--the Paradox of Prevention and Induction with Complete Freund's Adjuvant

1972 • 8 citations

Is local antigen persistence responsible for the chronicity of the experimental immune arthritis of the rabbit?

1976 • 8 citations

ADJUVANT-INDUCED POLYARTHRITIS IN RATS -ITS HISTOGENESIS^†

1966 • 7 citations

Effect of Degradation of the Arabinogalactan Portion of a Water-Soluble Component from <i>M. tuberculosis</i> Wax D on Polyarthritis Induction in the Rat

1976 • 7 citations

Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test

1971 • 7 citations

The effect of adjuvant arthritis and drugs on the ability of rat plasma to inhibit the triton X-100 induced lysis of rabbit polymorphonuclear leucocyte granules

1973 • 7 citations

Suppression of Adjuvant Arthritis by Penicillamine in Pyridoxine Deficient Rats

1974 • 6 citations

Role of host factors in the pathogenesis of Salmonella-associated arthritis in rats

1976 • 6 citations

Arthritis and Psoriasis: The Effects of Antipsoriatic Agents in the Adjuvant-Induced Arthritic Rat

1970 • 5 citations

Antiarthritic Effects of the Antispermatogenic Agent 2,3-Dihydro-(1-naphthyl)-4-(1H)-quinazolinone (U-29,409)

1971 • 5 citations

Arthritogenicity and protective effect against adjuvant arthritis of wax DS fractions (glycolipids without a nitrogen-containing moiety) ofMycobacterium tuberculosis var.hominis andbovis

1968 • 5 citations

Serum protein changes in Still's disease, rheumatoid arthritis and gout.

1970 • 4 citations

An automatic device for the measurement of oedema in the feet of rats and guinea pigs

1971 • 4 citations

[Studies on adjuvant arthritis of rats. I. Dosage, composition and administration forms of the adjuvant].

1969 • 3 citations

The effect of alloxan diabetes upon adjuvant-induced arthritis in the rat

1968 • 3 citations

Experimental Viral Arthritis Induced with Herpes Simplex

1972 • 1 citations