Recent developments in disease-modifying antirheumatic drugs

Lysosomes in biology and pathology

1977 • 2,068 citations

Lysosomotropic agents

1974 • 1,887 citations

ANKYLOSING SPONDYLITIS AND HL-A 27

1973 • 1,801 citations

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis

1973 • 1,365 citations

CYCLOSPORIN A IN PATIENTS RECEIVING RENAL ALLOGRAFTS FROM CADAVER DONORS

1978 • 1,010 citations

Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

1977 • 710 citations

Penicillamine, a new oral therapy for Wilson's disease

1956 • 694 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

Prostaglandin-Producing Suppressor Cells in Hodgkin's Disease

1977 • 552 citations

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT

1963 • 523 citations

Dissociation of Human Serum Macroglobulins

1957 • 460 citations

Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit ausTrichoderma polysporum(L<scp>INK</scp>ex P<scp>ERS</scp>.)Rifai

1976 • 373 citations

B-cell suppression of delayed hypersensitivity reactions

1974 • 346 citations

Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs.

1978 • 335 citations

HYPERAMMONÆMIA

1962 • 328 citations

IMMUNE-COMPLEX GLOMERULOPATHY IN PATIENTS TREATED WITH CAPTOPRIL

1980 • 305 citations

The phagocytic cell in host resistance

1975 • 297 citations

Gold Therapy in Rheumatoid Arthritis: Final Report of a Multicentre Controlled Trial

1961 • 284 citations

PSEUDOMEMBRANOUS COLITIS ASSOCIATED WITH CLINDAMYCIN

1974 • 270 citations

Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide.

1972 • 252 citations

Effect of Penicillamine on Cystinuria

1963 • 251 citations

Studies on bredinin. I. Isolation, characterization and biological properties.

1974 • 250 citations

WILSON'S DISEASE

1956 • 250 citations

CONTROLLED TRIAL OF D(-)PENICILLAMINE IN SEVERE RHEUMATOID ARTHRITIS

1973 • 232 citations

Loss of suppressor T cells in adult NZB/NZW mice.

1976 • 229 citations

Auranofin. New oral gold compound for treatment of rheumatoid arthritis.

1976 • 220 citations

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

1976 • 208 citations

The effect of gold salt on lysosomal enzymes of the peritoneal macrophage

1966 • 203 citations

THE PATHOGENESIS OF CHRONIC INFLAMMATION IN EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS

1972 • 203 citations

CYCLOPHOSPHAMIDE AND REPRODUCTIVE FUNCTION

1972 • 200 citations

Enhancement of delayed hypersensitivity by depletion of suppressor T cells with cyclophosphamide in mice

1976 • 198 citations

Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

1977 • 195 citations

Tilorone Hydrochloride: An Orally Active Antiviral Agent

1970 • 189 citations

STIMULATION BY ENDOCYTOSIS OF THE SECRETION OF COLLAGENASE AND NEUTRAL PROTEINASE FROM RABBIT SYNOVIAL FIBROBLASTS

1974 • 180 citations

Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levels

1975 • 177 citations

Prostaglandins and the immune response

1977 • 176 citations

Urinary-Bladder Fibrosis and Telangiectasia Associated with Long-Term Cyclophosphamide Therapy

1971 • 172 citations

STRONG ASSOCIATION BETWEEN HLA-DRW2 AND ANTIBODY-MEDIATED GOODPASTURE'S SYNDROME

1978 • 169 citations

AUTOPHAGIC VACUOLES PRODUCED IN VITRO

1968 • 159 citations

EFFECT OF PENICILLAMINE ON HUMAN COLLAGEN AND ITS POSSIBLE APPLICATION TO TREATMENT OF SCLERODERMA

1966 • 158 citations

Inactivation of lysosomal function in normal cultured human fibroblasts by chloroquine

1973 • 153 citations

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

1977 • 149 citations

Infection and Immunology in the Rheumatic Diseases

1977 • 149 citations

Controlled trial of cyclophosphamide in rheumatoid arthritis

1976 • 149 citations

Regulation of Delayed-Type Hypersensitivity Reactions by Cyclophosphamide-Sensitive T Cells

1978 • 146 citations

Course and Prognosis in Rheumatoid Arthritis

1957 • 145 citations

Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.

1975 • 144 citations

Comparison of the Effect of Plasmapheresis and Penicillamine on the Level of Circulating Rheumatoid Factor

1963 • 143 citations

DISTURBANCES OF AMINOACID METABOLISM FOLLOWING LIVER INJURY&lt;sup&gt;1&lt;/sup&gt;&lt;subtitle&gt;A Study by means of Paper Chromatography&lt;/subtitle&gt;

1953 • 140 citations

IMMUNOSTIMULANT THERAPY WITH LEVAMISOLE FOR RHEUMATOID ARTHRITIS

1976 • 137 citations

Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy

1972 • 135 citations

Chloroquine serum concentration and side effects: Evidence for dose‐dependent kinetics

1979 • 135 citations

The treatment of rheumatoid arthritis and necrotizing vasculitis with penicillamine

1970 • 134 citations

Comparison of Azathioprine, Cyclophosphamide, and Gold in Treatment of Rheumatoid Arthritis

1974 • 132 citations

CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDING

1969 • 130 citations

Control of neoplasia by modulation of the immune system

1977 • 130 citations

In Vitro Stimulation of Neutrophil Motility by Levamisole: Maintenance of cGMP Levels in Chemotactically Stimulated Levamisole-Treated Neutrophils

1976 • 125 citations

Penicillamine in Rheumatoid Disease: A Long-term Study

1974 • 122 citations

Chloroquine Diphosphate in Rheumatoid Arthritis : A Controlled Trial

1961 • 122 citations

Selective concentration and localization of gold in macrophages of synovial and other tissues during and after chrysotherapy in rheumatoid patients.

1976 • 121 citations

Chloroquine in Rheumatoid Arthritis: A Double Blindfold Trial of Treatment for One Year

1960 • 121 citations

Antigen recognition by T lymphocytes

1972 • 120 citations

Effect of 6-mercaptopurine on inflammation.

1962 • 114 citations

Suppressor-Cell Antibody in Systemic Lupus Erythematosus

1979 • 112 citations

High-affinity binding sites for prostaglandin E on human lymphocytes

1979 • 107 citations

DEFECTIVE RETICULOENDOTHELIAL SYSTEM FUNCTION IN RHEUMATOID ARTHRITIS

1979 • 98 citations

The Phagocytic cell in host resistance

1975 • 97 citations

Trial comparing D-penicillamine and gold in rheumatoid arthritis. Preliminary report.

1974 • 95 citations

Textbook of the Rheumatic Diseases

1949 • 94 citations

Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.

1970 • 93 citations

Thymus-like activities of sulphur derivatives on T-cell differentiation.

1977 • 93 citations

Effect of Chloroquine on Morphology of Cytoplasmic Granules in Maturing Human Leukocytes—an Ultrastructural Study*

1967 • 92 citations

Modulation of Immune Reactivity by Phenylimidothiazole Salts in Mice Immunized by Sheep Red Blood Cells

1974 • 91 citations

Effect of Gold on Progression of Erosions in Rheumatoid Arthritis: Better Results with Early Treatment

1977 • 89 citations

Studies on the Pharmacology of Chloroquine

1963 • 89 citations

Perspectives in Inflammation

1977 • 89 citations

Clinical evaluation of D‐penicillamine by multicentric double‐blind comparative study in chronic rheumatoid arthritis

1977 • 89 citations

Orgotein: a new anti-inflammatory metalloprotein drug: preliminary evaluation of clinical efficacy and safety in degenerative joint disease.

1974 • 89 citations

Salazopyrin in rheumatoid arthritis

1978 • 87 citations

Penicillamine, a Characteristic Degradation Product of Penicillin

1943 • 87 citations

Melanoma in Sinclair Swine: A New Animal Model

1974 • 86 citations

Salazopyrin in the Treatment of Rheumatoid Arthritis

1949 • 85 citations

Effects of levamisole on normal and abnormal leukocyte locomotion.

1977 • 85 citations

Gold nephropathy prototype of membranous glomerulonephritis.

1974 • 85 citations

The lymphocyte transformation test and gold hypersensitivity.

1968 • 84 citations

Novel treatment for joint inflammation

1978 • 84 citations

Inhibition of Immediate and Delayed Hypersensitivity in the Rabbit by 6-Mercaptopurine

1964 • 83 citations

Azathioprine in early rheumatoid arthritis

1977 • 83 citations

Therapeutic studies in NZB/W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone

1972 • 83 citations

The anti‐inflammatory effect of some immunosuppressive agents

1969 • 82 citations

Penicillamine Research in Rheumatoid Disease

1978 • 81 citations

Pathology of Rheumatoid Arthritis

1938 • 79 citations

Immunological phagocytosis: Effect of drugs on phosphodiesterase activity

1974 • 79 citations

An appraisal of chloroquine

1970 • 79 citations

Copeman's Textbook of the Rheumatic Diseases.

1991 • 78 citations

D‐Penicillamine in rheumatoid arthritis

1970 • 78 citations

Azathioprine in rheumatoid arthritis

1975 • 78 citations

Chloroquine Retinopathy in Patients with Rheumatoid Arthritis

1976 • 76 citations

Effects of anti-inflammatory and other compounds on the release of lysosomal enzymes from macrophages

1975 • 76 citations

Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.

1976 • 75 citations

The Use of a Standardized Adjuvant Arthritis Assay to Differentiate Between Anti-inflammatory and Immunosuppressive Agents

1971 • 74 citations

The effect of cyclophosphamide on b and t lymphocytes in patients with connective tissue diseases

1975 • 72 citations

Toxicity of D-penicillamine in rheumatoid arthritis

1978 • 72 citations

Use of dimercaprol or pencillamine in the treatment of cystinosis.

1961 • 71 citations

EFFECT OF DMSO ON THE STABILIZATION OF LYSOSOMES BY CORTISONE AND CHLOROQUINE IN VITRO*

1967 • 71 citations

Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat.

1973 • 71 citations

Effect of D-penicillamine on serum immunoglobulins and rheumatoid factor.

1973 • 69 citations

DAPSONE IN RHEUMATOID ARTHRITIS

1976 • 69 citations

STUDIES ON THE ANTI-INFLAMMATORY ACTION OF 6-MERCAPTOPURINE

1968 • 68 citations

The Qa-1 antigenic system. Relation of Qa-1 phenotypes to lymphocyte sets, mitogen responses, and immune functions.

1978 • 68 citations

Chloroquine, quinine, procaine, quinidine and clomipramine are prostaglandin agonists and antagonists

1976 • 68 citations

Production of Graft-Versus-Host Disease in the Rat and its Treatment with Cytotoxic Agents

1966 • 68 citations

Chrysotherapy. suppression of immunoglobulin synthesis

1978 • 67 citations

The value of chloroquine in rheumatoid disease: a four-year study of continuous therapy.

1957 • 67 citations

Inhibition of lysosomal enzyme release from rat leukocytes by auranofin

1977 • 67 citations

IS CHLOROQUINE OBSOLETE IN TREATMENT OF RHEUMATIC DISEASE?

1979 • 66 citations

Structure of an antigen-specific suppressor factor produced by a hybrid T-cell line

1979 • 66 citations

THE METABOLISM OF AZATHIOPRINE IN RENAL FAILURE

1971 • 63 citations

Azathioprine and penicillamine in treatment of rheumatoid arthritis: a controlled trial.

1976 • 63 citations

Intra-articular dissociation of the rheumatoid factor.

1962 • 63 citations

A double‐blind trial of high versus conventional dosages of gold salts for rheumatoid arthritis

1977 • 63 citations

Characterization of the immunostimulants levamisole and tetramisole

1975 • 63 citations

Selective inhibition of prostaglandin biosynthesis by gold salts and phenylbutazone

1975 • 62 citations

Enzyme release from human leukocytes and degradation of cartilage matrix effects of antirheumatic drugs

1974 • 61 citations

Immunosuppression by Cyclophosphamide in NZB X NZW Mice With Lupus Nephritis

1968 • 61 citations

Inhibition of Prostaglandin Synthesis and Human Epidermal Enzymes by Aurothiomalate in Vitro: Possible Actions of Gold in Pemphigus*

1974 • 60 citations

Comparative effects of drugs on four paw oedema models in the rat

1979 • 60 citations

Effect of a gold salt on the immune response

1967 • 59 citations

Effect of Gold Treatment on the Progression of Erosions in Ra Patients

1977 • 59 citations

Slow Extrarenal Excretion of Digoxin

1973 • 59 citations

EVIEDENCE THAT D-PENICILLAMINE ALTERS THE COURSE OF RHEUMATOID ARTHRITIS

1976 • 58 citations

Rheumatoid Arthritis in a New England Town

1970 • 58 citations

The effect of D-penicillamine on polymorphonuclear leukocyte function.

1976 • 56 citations

Characterization of cathepsins in cartilage

1967 • 56 citations

Methyl ester of n‐formylmethionyl‐leucyl‐phenylalanine. Chemotactic responses of human blood monocytes and inhibition of gold compounds

1978 • 55 citations

Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver

1971 • 54 citations

Mechanisms of immunosuppression: effects of cyclophosphamide on lymphocytes.

1972 • 53 citations

Action of chloroquine phosphate in rheumatoid arthritis. 1. Immunosuppressive effect.

1973 • 53 citations

Studies with 35S-labelled DL-Penicillamine in Patients with Wilson's Disease

1971 • 53 citations

Ambivalent role of copper in inflammatory disorders

1976 • 53 citations

The Curative Effect of Certain Gold Compounds on Experimental Proliferative, Chronic Arthritis in Mice

1940 • 53 citations

Chemical action and pharmacology of methotrexate, azathioprine and cyclophosphamide in man

1973 • 52 citations

Effects of levamisole on human monocyte function and immunoprotein receptors

1976 • 52 citations

Failure of oral D-penicillamine to modify adjuvant arthritis or immune response in the rat.

1972 • 51 citations

Chemotaxis of polymorphonuclear leukocytes

1968 • 51 citations

The Pathology of Rheumatoid Arthritis

1973 • 50 citations

DRUG TREATMENT OF RHEUMATOID ARTHRITIS

1975 • 50 citations

MYCOBACTERIAL ADJUVANT PERIARTHRITIS IN RODENTS AND ITS MODIFICATION BY ANTIINFLAMMATORY AGENTS

1966 • 50 citations

Copeman's Textbook of the Rheumatic Diseases.

1978 • 50 citations

The effect of azathioprine (Imuran) on the kinetics of monocytes and macrophages during the normal steady state and an acute inflammatory reaction

1975 • 50 citations

Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and levamisole.

1978 • 49 citations

Inhibition of lysosomal enzymes by dapsone

1975 • 49 citations

Toxicity of immunosuppressive drugs in man

1973 • 49 citations

Investigations on the Reaction of Metals with Collagen in vivo

1968 • 47 citations

Some copper coordination compounds and their antiinflammatory and antiulcer activities

1976 • 47 citations

Effect of auranofin, a new antiarthritic agent, on immune complex-induced release of lysosomal enzymes from human leukocytes

1977 • 47 citations

Complications of Chrysotherapy

1979 • 46 citations

Kinetic studies of phagocytosis.

1978 • 46 citations

Demonstration of the Exposure of New Antigenic Determinants Following Antigen–antibody Combination

1965 • 45 citations

Tilorone: Its Selective Effects on Humoral and Cell-Mediated Immunity

1974 • 45 citations

Ribavirin: Efficacy in the Treatment of Murine Autoimmune Disease

1977 • 45 citations

The Effect of Salicylate and Chloroquine on Prostaglandin-Induced Articular Damage in the Rabbit Knee

1975 • 44 citations

Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis

1976 • 44 citations

An in vitro demonstration of proteolysis by macrophages and its increase with coumarin

1975 • 44 citations

Localization of gold in synovial membrane of rheumatoid arthritis treated with sodium aurothiomalate. Studies by electron microscope and electron probe x-ray microanalysis.

1977 • 43 citations

Penicillamine and Collagen Metabolism

1979 • 43 citations

Biochemical properties of anti-inflammatory drugs—VII. Inhibition of proteolytic enzymes in connective tissue by chloroquine (resochin) and related antimalarial/antirheumatic drugs

1966 • 43 citations

The influence of chrysotherapy on serum protein and immunoglobulin levels, rheumatoid factor, and antiepithelial antibody titers.

1975 • 43 citations

Effect of chloroquine on morphology of leukocytes and pancreatic exocrine cells from the rat.

1968 • 43 citations

Penicillamine in Rheumatoid Arthritis: Adverse Effects

1979 • 42 citations

Cyclophosphamide Therapy for Rheumatoid Arthritis

1975 • 42 citations

SK&F 36914--an agent for oral chrysotherapy.

1972 • 42 citations

Experimental immune synovitis in the rabbit. Relative roles of cell mediated and humoral immunity

1974 • 42 citations

Investigations on the influence of Cyclophosphamide, gold sodium thiomalate andd-penicillamine on nystatin oedema and adjuvant arthritis

1975 • 41 citations

Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.

1974 • 41 citations

Distribution of gold in the animal body in relation to arthritis.

1948 • 41 citations

The Pharmacological and Immunological Basis for the Use of Immunosuppressive Drugs

1976 • 41 citations

CHLOROQUINE: A REVIEW

1976 • 40 citations

Immunoresponsiveness of patients with rheumatoid arthritis receiving cyclophosphamide or gold salts.

1973 • 40 citations

NON‐IMMUNOLOGICAL RELEASE OF SLOW‐REACTING SUBSTANCE FROM GUINEA‐PIG LUNGS

1979 • 40 citations

Rheumatic diseases : diagnosis and management

1977 • 40 citations

THE TREATMENT OF METAL POISONING WITH PENICILLAMINE

1957 • 39 citations

Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

1971 • 39 citations

SULINDAC IN OSTEOARTHROSIS OF THE HIP

1976 • 38 citations

Articular Damage in Arthritis and Its Control

1978 • 38 citations

Textbook of the Rheumatic Diseases.

1970 • 38 citations

Immunopharmacology of gold sodium thiomalate and auranofin (SK&amp;F D-39162)

1978 • 37 citations

B lymphocyte alloantigens in the study of the genetic basis of rheumatoid arthritis.

1977 • 36 citations

Inhibition of human granulocyte elastase by gold sodium thiomalate

1970 • 35 citations

N-Carboxyphenyl)-4-chloroanthranilic acid disodium salt: a novel anti-arthritic agent without anti-inflammatory and immunosuppressive activities

1977 • 35 citations

The effect of drugs in established rabbit monoarticular arthritis

1977 • 35 citations

LEVAMISOLE IN RHEUMATOID ARTHRITIS

1978 • 33 citations

Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.

1977 • 32 citations

Effect of gold on the immune response of mice

1975 • 32 citations

Cryoglobulinemia associated with a macroglobulin

1965 • 32 citations

Cartilage changes in the rheumatoid joint.

1969 • 31 citations

N-(2-Carboxyphenyl)-4-chloroanthranilic acid disodium salt: prevention of autoimmune kidney disease in NZB/NZW F1 hybrid mice

1978 • 31 citations

Gold-associated thrombocytopenia. Report six cases.

1974 • 30 citations

Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein)

1977 • 30 citations

Penicillamine deprotonations and interactions with copper ions

1971 • 30 citations

The interaction of aurothiomalate and cysteine

1976 • 30 citations

Essential cryoglobulinemia. Immunologic studies before and after penicillamine therapy.

1970 • 29 citations

Immunosuppressive Therapy in Rheumatic Disease

1977 • 29 citations

Inhibition of the alternative pathway of complement by gold sodium thiomalate in vitro.

1978 • 29 citations

PENICILLAMINE IN RHEUMATOID ARTHRITIS: WOUND HEALING, SKIN THICKNESS AND OSTEOPOROSIS

1977 • 29 citations

CELL-MEDIATED IMMUNITY TO SYNOVIAL ANTIGENS IN RHEUMATOID ARTHRITIS

1973 • 29 citations

Effect of Gold Salts and Antimalarials on the Rheumatoid Factor in Rheumatoid Arthritis

1973 • 28 citations

Studies on phagocytosis. II. The effect of nonsteroidal anti-inflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation.

1972 • 28 citations

Protective effect of levamisole and its sulfhydryl metabolite OMPI against cell death induced by glutathione depletion

1979 • 28 citations

Cyclophosphamide treatment of rheumatoid arthritis

1969 • 27 citations

A Defect in the Intramolecular and Intermolecular Cross-linking of Collagen Caused by Penicillamine

1973 • 27 citations

Some Aspects of the Mechanism of Action of Penicillamine in Rheumatoid Arthritis

1979 • 27 citations

Uptake of gold by collagen in gold therapy.

1965 • 26 citations

Gold and Thiol Compounds in the Treatment of Rheumatoid Arthritis

1979 • 26 citations

The anti-inflammatory profile of dapsone in animal models of inflammation

1978 • 26 citations

The Anti-inflammatory Actions of Tilorone Hydrochloride

1975 • 26 citations

Comparison of in vivo and in vitro effects of chloroquine on hepatic lysosomes

1969 • 26 citations

Effect of Gold Preparations on the Development and Passive Transfer of Experimental Allergic Encephalomyelitis in Rats

1972 • 25 citations

Immunotherapy with Levamisole in Rheumatic Diseases

1976 • 24 citations

THE EFFECTS OF <scp>d‐</scp>PENICILLAMINE AND LEVAMISOLE ON LEUCOCYTE CHEMOTAXIS IN THE RAT

1978 • 24 citations

Penicillamine in Rheumatoid Arthritis: Clinical Pharmacology and Biochemical Properties

1979 • 24 citations

THE IMMUNOSUPPRESSIVE MECHANISM OF AZATHIOPRINE

1976 • 24 citations

Effect of the elimination of suppressor cells on the development of DNCB contact sensitivity in guinea-pig.

1977 • 23 citations

METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS IN THE TREATMENT OF ARTHRITIS II. A COMPARATIVE STUDY OF THE DISTRIBUTION AND EXCRETION OF GOLD FOLLOWING THE INTRAMUSCULAR INJECTION OF FIVE DIFFERENT GOLD COMPOUNDS

1941 • 23 citations

Interaction of D‐Penicillamine with Gold Salts

1977 • 23 citations

Cytotoxic Agents in the Treatment of Rheumatoid Arthritis

1978 • 23 citations

Genetic and epigenetic control of levamisole-induced immunostimulation

1979 • 23 citations

Use of the reversed passive arthus reaction as a test for anti-inflammatory agents

1975 • 23 citations

Effects of several antitumour agents on spleen hemolysin plaque-forming cells

1967 • 22 citations

The role of prostaglandins in the control of the immune response to an autologous red blood cell antigen (Hb)

1977 • 22 citations

Interaction of Aurothiomalate with Human Serum Albumin in vitro

1976 • 22 citations

Increased infiltration by monocytes in delayed type hypersensitivity site following cyclophosphamide treatment.

1978 • 22 citations

Complement: A Host Defense Mechanism Ready for Pharmacological Manipulation?

1977 • 21 citations

Influence of D-Penicillamine Treatment on the Humoral Immune System

1979 • 21 citations

Inhibition of the Alternative Pathway of Complement by Gold Sodium Thiomalate in Vitro

1978 • 21 citations

Drugs and Immune Responsiveness

1980 • 20 citations

Disparity between clinical and immune responses in a controlled trial of azathioprine in rheumatoid arthritis

1976 • 20 citations

INHIBITION OF PRECURSOR INCORPORATION INTO NUCLEIC ACIDS OF MAMMALIAN TISSUES BY ANTIMALARIAL AMINOQUINOLINES

1978 • 20 citations

Inhibition of synovial fluid lysosomal glycosidases by anti-Arthritic gold preparations

1978 • 20 citations

The value of multifactorial screening for anti‐inflammatory activity as shown by coumarin

1977 • 20 citations

Alclofenac and D-penicillamine. Comparative trial in rheumatoid arthritis.

1978 • 19 citations

Effect of Anti-Arthritic Drugs on Sulfhydryl Reactivity of Rat Serum

1972 • 19 citations

LEVAMISOLE AND FUNCTIONS OF PERITONEAL MACROPHAGES

1975 • 19 citations

Delayed Hypersensitivity to Tuberculin in Rats: Effects of Antirheumatic Drugs

1979 • 19 citations

Essential Cryoglobulinemia

1970 • 18 citations

Gold-Associated Thrombocytopenia

1974 • 18 citations

Clinical Use of Immunosuppressive Drugs

1976 • 18 citations

Studies on lysosome stabilization by antirheumatic drugs

1970 • 17 citations

Inhibition of Eosinophilotaxis by Chloroquine and Corticosteroids

1978 • 16 citations

An analysis of the inhibitory effects and of possible prostaglandins antagonism of chloroquine in the guinea-pig isolated ileum

1977 • 16 citations

Chloroquine: Protective and Destructive Effects on Injured Rabbit Cartilage In Vivo

1973 • 16 citations

Interaction of Antimalarial Aminoquinolines (Primaquine, Pentaquine, and Chloroquine) with Nucleic Acids, and Effects on Various Enzymatic Reactions in Vitro

1971 • 16 citations

In vitro inhibition of the biosynthesis of a prostaglandin by gold and silver

1973 • 16 citations

Possible relationships between an infectious agent and the immune reactions of rheumatoid synovitis

1973 • 16 citations

The prophylactic and therapeutic effects of gold sodium thiomalate against adjuvant-induced polyarthritis in rats

1973 • 15 citations

The influence of prolonged treatment with D-penicillamine on the immune response in Wilson's disease

1977 • 15 citations

EFFECT OF PENICILLAMINE ON PERIPHERAL-BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS

1975 • 14 citations

CHLOROQUINE PHOSPHATE (ARALEN) IN THE LONG-TERM TREATMENT OF RHEUMATOID ARTHRITIS

1959 • 14 citations

Selective inhibitors of lecithin biosynthesis in mouse peritoneal macrophages

1979 • 14 citations

Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.

1979 • 14 citations

Effect of penicillamine on complement in vitro and in vivo.

1977 • 14 citations

Effects of anti-inflammatory and immuno-modulating agents on the release of β-glucuronidase and collagenase from cultured macrophages of guinea pigs

1979 • 13 citations

Lack of effect of gold therapy on abnormal IgG and IgM metabolism in rheumatoid arthritis

1974 • 13 citations

A comparison of tissue gold levels in guinea-pigs after treatment with Myocrisin injected intramuscularly and triethylphosphine gold chloride and Myocrisin administered orally

1978 • 13 citations

The Inhzbitory Effect of D-Penicillamine on Human Lymphocyte Cultures Stimulated by Phytohaemagglutinin, The Antagonistic Action of L-Cysteine and Synergistic Inhibition by Copper Sulphate

1979 • 13 citations

Penicillamine in rheumatoid arthritis ‐ A 2 year retrospective study in 70 patients

1977 • 12 citations

Precipitating autoantibody to a ubiquitous tissue antigen: Association with rheumatoid arthritis treated with sodium aurothiomalate or d-penicillamine

1978 • 12 citations

Alteration of lymphocyte function in nzb/nzw mice

1979 • 12 citations

Anti-arthritic activity of bredinin, an immunosuppressive agent

1977 • 12 citations

Pathogenesis of chlamydial polyarthritis in domestic animals: characteristics of causative agent.

1979 • 11 citations

Effect of Low Dosage Schedule of D-Penicillamine on Collagen Cross-Linking in a Nine Week Immobilized Rabbit Knee

1977 • 11 citations

Relation between Delayed Hypersensitivity and Cell-Mediated Immunity

1979 • 11 citations

Potential Antiarthritic Agents I: Benzoylacetonitriles

1979 • 11 citations

Gold Compounds in Rheumatoid Arthritis: Report of a Symposium

1977 • 11 citations

The effect of gold salts on the biosynthesis of uridine nucleotides in human granulocytes

1974 • 10 citations

[Drug induced damage to vision, hearing, balance and motility according to a common mechanism].

1975 • 9 citations

STUDIES OF THE EFFECTS OF HYDROXYCHLOROQUINE ON IMMUNE RESPONSES.

1965 • 9 citations

Comparison of the immunosuppressive efficacy of 6-mercaptopurine, azathioprine, cyclophosphamide and 036.5122 (Asta) on the primary and secondary immune response of mice to sheep erythrocytes

1976 • 8 citations

Tilorone hydrochloride: a non-steroidal anti-inflammatory agent devoid of prostaglandin synthetase inhibitory activity

1976 • 8 citations

A New Anti-Inflammatory Drug, Proquazone, and Ibuprofen in the Treatment of Degenerative Joint Disease of the Knee (Gonarthrosis): A Double-blind Comparative Study

1978 • 8 citations

Sensitization of Guinea Pigs to Levamisole

1979 • 8 citations

Cell transfer studies in cyclophosphamide-induced tolerance

1973 • 8 citations

Levamisole inhibits mineral mobilisation, lactate production and lysosomal enzyme release from cultured bones

1979 • 8 citations

Gold excretion in rheumatoid arthritis.

1971 • 8 citations

Effects of cyclophosphamide o immune arthritis in the guinea-pig.

1971 • 7 citations

Restoration of methotrexate-suppressed oxazolone-induced contact sensitivity with levamisole

1978 • 7 citations

DEVELOPMENT OF MODELS FOR PENICILLAMINE-LIKE DRUGS

1976 • 7 citations

Rheumatic diseases : [papers read at the third symposium of the Pfizer Foundation of the Post-Graduate Medical School, University of Edinburgh, 1967]

1968 • 7 citations

The immunopharamacologic and anti-inflammatory properties of RMI 9563 with special reference to its effect on the complement system

1978 • 6 citations

Influence of Nonsteroidal Antirheumatic Drugs on Collagen Metabolism in Rats with Adjuvant-Induced Arthritis

1974 • 6 citations

Action of chloroquine on pleurisy due to Bordetella pertussis hypersensitivity

1978 • 6 citations

Suppression of Adjuvant Arthritis by Penicillamine in Pyridoxine Deficient Rats

1974 • 6 citations

Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat

1976 • 6 citations

Effects of D-Penicillamine on lymphocyte modulation of synovial collagenase production

1979 • 6 citations

Selected Therapeutic Problems in Rheumatoid Arthritis

1975 • 6 citations

The Effect of Hydrocortisone Acetate and Azathioprine (Imuran) on the Kinetics of Neutrophilic Polymorphonuclear Leucocytes during an Acute Inflammation

1977 • 5 citations

Effects of Levamisole and &lt;i&gt;D&lt;/i&gt;-Penicillamine in Rat Paw Oedema Induced by Carrageenan and by Kaolin

1979 • 5 citations

Complexes of Biologically Active Substances with Nucleic Acids — Yesterday, Today, Tomorrow

1971 • 5 citations

Questionable Effects of Myocrisin in Experimental Arthritis in Rabbits

1975 • 5 citations

New types of therapy for the arthropathies and inflammatory disease

1978 • 5 citations

The Influence of Chloroquine Upon the Metabolism of Collagen in Rat

1970 • 4 citations

Cyclophosphamide and collagen. The effect of cyclophosphamide on the biochemistry of collagen in granulation tissue, skin, and aorta. Experimental studies in rats and a discussion of the relevance of the observed results in relation to rheumatic diseases.

1979 • 3 citations

The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos

1968 • 3 citations

Constrictive peri carditis and rheumatoid arthritis

1979 • 2 citations

Effect of D-Penicillamine on Release of Mucopolysaccharidases by Lysosomal Labilizers in Cultured Fibroblasts

1977 • 2 citations

Immune Reactions and Experimental Models in Rheumatic Diseases

1972 • 2 citations

ORAL ULCERATION AND LYMPHOCYTE REACTIONS IN RHEUMATOID-ARTHRITIS PATIENTS ON GOLD THERAPY

1976 • 2 citations

List of subjects

1978 • 1 citations

The effect ofd-penicillamine on fibroblast-leukocyte interaction in vitro

1976 • 1 citations

The failure of long term effect of cyclophosphamide on systemic immunologic connective tissue disease in rabbit.

1978 • 1 citations

The effect of D-penicillamine on humoral and cellular immune responses in animals

1979 • 1 citations

SEARCH FOR MICROBES IN ARTHRITIS

1976 • 1 citations