Physiological roles for adenosine and adenosine 5′-triphosphate in the nervous system

Handbook of Psychopharmacology

1988 • 2,778 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

On the Regulation of the Blood‐supply of the Brain

1890 • 1,743 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

1970 • 1,041 citations

SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977

1977 • 935 citations

A basis for distinguishing two types of purinergic receptor

1978 • 725 citations

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

1970 • 671 citations

Do some nerve cells release more than one transmitter?

1976 • 633 citations

PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.

1977 • 616 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

1975 • 559 citations

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

1980 • 542 citations

The Role of Adenosine and 2'-Deoxyadenosine in Mammalian Cells

1978 • 518 citations

Release of Adenosine from Ischemic Brain

1974 • 514 citations

Uptake of Catecholamines by a Particulate Fraction of the Adrenal Medulla

1962 • 510 citations

Chemical and Molecular Basis of Nerve Activity

1975 • 480 citations

Th molecular organization of adrenal chromaffin granules

1980 • 455 citations

The composition of adrenal chromaffin granules: An assessment of controversial results

1976 • 435 citations

Cyclic nucleotides and nervous system function.

1977 • 411 citations

Aminopyridines and synaptic transmission

1980 • 404 citations

The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat

1972 • 366 citations

Observations on the elimination of polyneuronal innervation in developing mammalian skeletal muscle.

1978 • 363 citations

Synaptic vesicles in sympathetic neurons.

1971 • 357 citations

ADENINE NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE in vitro RAT HIPPOCAMPUS

1980 • 357 citations

Neurobiology of Invertebrates

1968 • 348 citations

Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

1978 • 347 citations

The presence of ineffective synapses and the circumstances which unmask them

1977 • 340 citations

On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals.

1975 • 333 citations

Metabolic co-operation between biochemically marked mammalian cells in tissue culture

1969 • 325 citations

PURINERGIC INNERVATION OF THE GUINEA‐PIG URINARY BLADDER

1978 • 323 citations

Control of cell-contact sites by cyclic AMP pulses in differentiating Dictyostelium cells

1975 • 320 citations

Cyclic Nucleotides in the Nervous System

1977 • 297 citations

Role of cyclic nucleotides in cell growth and differentiation

1976 • 290 citations

Adenosine triphosphate. A constituent of cholinergic synaptic vesicles

1974 • 288 citations

Effects of adenosine on adrenergic neurotransmission; Prejunctional inhibition and postjunctional enhancement

1976 • 288 citations

Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells

1977 • 267 citations

The role of cyclic nucleotides in central synaptic function

1975 • 263 citations

The regulation of cell proliferation by calcium and cyclic AMP

1979 • 259 citations

LOW PREVALENCE OF HUNTINGTONS-DISEASE IN FINLAND

1900 • 254 citations

The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine

1976 • 252 citations

Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.

1976 • 240 citations

The capillary dilator substances in dry powders of spinal roots; a possible role of adenosine triphosphate in chemical transmission from nerve endings

1954 • 233 citations

Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides

1979 • 222 citations

Regulation of adenylate cyclase by adenosine

1979 • 218 citations

Secretion of cyclic AMP induced by cyclic AMP in the cellular slime mould Dictyostelium discoideum

1975 • 216 citations

Direct evidence for ATP release from non-adrenergic, non-cholinergic (“purinergic”) nerves in the guinea-pig taenia coli and bladder

1978 • 216 citations

Cyclic AMP and Cyclic GMP May Mediate Opposite Neuronal Responses in the Rat Cerebral Cortex

1975 • 216 citations

Brain adenosine production in the rat during 60 seconds of ischemia.

1979 • 213 citations

Adenine derivatives as neurohumoral agents in the brain. The quantities liberated on excitation of superfused cerebral tissues

1972 • 211 citations

Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum

1979 • 210 citations

Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline.

1976 • 209 citations

[ ³ H]Adenosine Triphosphate: Release during Stimulation of Enteric Nerves

1971 • 204 citations

Relationship between adenosine concentration and oxygen supply in rat brain

1975 • 202 citations

Cellular site of opiate dependence

1980 • 201 citations

THE EFFECTS OF ADENOSINE TRIPHOSPHATE AND ADENOSINE DIPHOSPHATE ON TRANSMISSION AT THE RAT AND FROG NEUROMUSCULAR JUNCTIONS

1975 • 191 citations

The present status of the vesicular hypothesis

1979 • 181 citations

Cytochemical localization of 5′-nucleotidase in glial plasma membranes

1978 • 179 citations

The Role of Cyclic Nucleotides in Central Synaptic Function

1975 • 177 citations

Inhibition of sympathetic neurotransmission in canine blood vessels by adenosine and adenine nucleotides.

1977 • 175 citations

The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline

1976 • 175 citations

RELEASE OF ATP FROM A SYNAPTOSOMAL PREPARATION BY ELEVATED EXTRACELLULAR K⁺ AND BY VERATRIDINE

1978 • 173 citations

Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium

1970 • 172 citations

A note of the mechanism by which inhibitors of the sodium pump accelerate spontaneous release of transmitter from motor nerve terminals.

1975 • 171 citations

COMPARATIVE PHYSIOLOGY OF SWEATING

2006 • 168 citations

Analysis and quantitative evaluation of the depressive effect of adenosine on evoked potentials in hippocampal slices

1979 • 166 citations

ADENOSINE INHIBITION OF γ‐AMINOBUTYRIC ACID RELEASE FROM SLICES OF RAT CEREBRAL CORTEX

1980 • 163 citations

On the composition and function of large dense cored vesicles in sympathetic nerves

1976 • 160 citations

Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists

1975 • 158 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Inhibition of slow action potentials of guinea pig atrial muscle by adenosine: A possible effect on Ca2+ influx

1975 • 157 citations

Subcellular distribution and movement of 5'-nucleotidase in rat cells

1980 • 156 citations

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex

1978 • 154 citations

UPTAKE AND RELEASE OF [¹⁴C]ADENINE DERIVATIVES AT BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES IN A SUPERFUSION SYSTEM

1974 • 153 citations

Adenosine-dependent formation of cyclic AMP in brain slices

1976 • 149 citations

Relationship between coronary flow and adenosine production and release

1974 • 148 citations

Outflux of various phosphates during membrane depolarization of excitable tissues

1962 • 147 citations

Depression of Corticospinal Cells by Various Purines and Pyrimidines

1974 • 146 citations

Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens

1977 • 145 citations

5?-Nucleotidase of microglial cells in the facial nucleus during axonal reaction

1978 • 144 citations

Physiological and regulatory functions of adenosine and adenine nucleotides

1979 • 144 citations

Cyclic Adenosine 3′,5′-Monophosphate in Guinea Pig Cerebral Cortical Slices

1973 • 143 citations

5′-AMP is a direct precursor of cytokinin in Dictyostelium discoideum

1978 • 143 citations

Chemical and molecular basis of nerve activity

1960 • 136 citations

Stimulation-dependent release of 3H-adenosine derivatives from central axon terminals to target neurones

1976 • 136 citations

Isolated 5‐hydroxytryptamine organelles of rabbit blood platelets: physiological properties and drug‐induced changes

1968 • 134 citations

Subcellular fractionation of splenic nerve: ATP, chromogranin A and dopamine β-hydroxylase in noradrenergic vesicles

1970 • 131 citations

Evidence for an adenosine receptor on the surface of dog coronary myocytes.

1976 • 130 citations

Effect of apamin on the electrical responses of smooth muscle to adenosine 5′-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation

1980 • 130 citations

Inhibition of the calcium-induced increase in the potassium permeability of human red blood cells by quinine.

1975 • 128 citations

A central role for denervated tissues in causing nerve sprouting

1979 • 127 citations

Evidence for ATP action on the cell surface

1974 • 126 citations

Regulation of cyclic adenosine 3',5'-monophosphate levels in guinea-pig cerebral cortex by interaction of alpha adrenergic and adenosine receptor activity.

1975 • 126 citations

Adenosine and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by potassium

1979 • 124 citations

DEPRESSION OF EVOKED POTENTIALS IN BRAIN SLICES BY ADENOSINE COMPOUNDS

1978 • 124 citations

Purinergic depression of neurons in different areas of the rat brain

1977 • 123 citations

Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP

1979 • 119 citations

Adenosine receptors in frog sinus venosus: slow inhibitory potentials produced by adenine compounds and acetylcholine.

1979 • 118 citations

Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney.

1978 • 116 citations

Neurotransmitter Receptor Interactions

1972 • 115 citations

A comparison of the effects of adenosine triphosphate with noradrenaline and with the inhibitory potential of the guinea‐pig taenia coli

1973 • 114 citations

Quasi morphine-abstinence syndrome

1974 • 112 citations

Purinergic inhibition of adrenergic transmission in rabbit blood vessels.

1978 • 107 citations

The dextro and levorotatory isomers of N-phenylisopropyladenosine: Stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices

1979 • 106 citations

Evidence for a cell surface adenosine receptor on coronary myocytes and atrial muscle cells

1977 • 106 citations

MAXIMUM ACTIVITIES, PROPERTIES AND DISTRIBUTION OF 5’NUCLEOTIDASE, ADENOSINE KINASE AND ADENOSINE DEAMINASE IN RAT AND HUMAN BRAIN

1979 • 106 citations

Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart

1979 • 106 citations

Evidence for Transfer of Enzyme Product as the Basis of Metabolic Cooperation between Tissue Culture Fibroblasts of Lesch-Nyhan Disease and Normal Cells

1970 • 105 citations

Possible feed-back inhibition of noradrenaline release by purine compounds

1977 • 104 citations

Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain

1971 • 102 citations

Microiontophoretic studies of the effects of cyclic nucleotides on excitability of neurones in the rat cerebral cortex

1977 • 100 citations

Cyclic AMP, cyclic AMP-dependent protein kinase, and the regulation of gene expression

1977 • 100 citations

Effects of caffeine on central monoamine neurons

1972 • 98 citations

Release of adenosine 5′-triphosphate from synaptosomes from different regions of rat brain

1980 • 97 citations

Concomitant changes in cyclic AMP level and postsynaptic potentials of olfactory cortex slices induced by adenosine derivatives

1976 • 97 citations

Putative endogenous ligands for the benzodiazepine receptor

1979 • 94 citations

Spike after-hyperpolarisation of a sympathetic neurone is calcium sensitive and is potentiated by theophylline

1976 • 93 citations

Postsynaptic Transmission Block Can Cause Terminal Sprouting of a Motor Nerve

1980 • 92 citations

Output of [14C]adenine nucleotides and their derivatives from cerebral tissues. Tetrodotoxine-resistant and calcium ion-requiring components

1973 • 91 citations

The release of 3H-adenosine and its derivatives from cat sensorimotor cortex

1975 • 88 citations

Brain adenosine production in rat during sustained alteration in systemic blood pressure

1980 • 88 citations

Turnover of adenine nucleotides in cholinergic synaptic vesicles of the Torpedo electric organ

1978 • 87 citations

Neurotransmitter-receptor interactions

1971 • 86 citations

The nature of receptors regulating the formation of cyclic AMP in brain tissue

1976 • 84 citations

Distribution and release of adenosine triphosphate in rat brain

1978 • 84 citations

Purine salvage at the cholinergic nerve endings of the Torpedo electric organ: The central role of adenosine

1979 • 83 citations

Release of Adenosine‐like Material from Isolated Perfused Dog Adipose Tissue Following Sympathetic Nerve Stimulation and its Inhibition by Adrenergic α‐Receptor Blockade

1976 • 81 citations

Purine nucleoside and nucleotide interactions on normal and subsensitive alpha adrenoreceptor responsiveness in guinea-pig vas deferens.

1978 • 81 citations

EVIDENCE FOR PURINERGIC INNERVATION OF THE ANOCOCCYGEUS MUSCLE

1978 • 79 citations

Release of ATP from stimulated nerve electroplaque junctions

1975 • 78 citations

Effects of catecholamines, ATP and ionophore A23187 on potassium and calcium movements in isolated hepatocytes

1979 • 77 citations

Correlation of 5′-nucleotidase activity and selective transneuronal transfer of adenosine in the hippocampus

1979 • 75 citations

Purinergic modulation of transmitter release

1979 • 75 citations

Potentiation of postjunctional cholinergic sensitivity of rat diaphragm muscle by high-energy-phosphate adenine nucleotides

1976 • 75 citations

Release of ³H‐nucleosides from ³H‐adenine labelled hypothalamic synaptosomes

1979 • 73 citations

Retrograde Inhibition of Transmitter Release by ATP

1980 • 72 citations

A characterization of the nucleotide uptake by chromaffin granules of bovine adrenal medulla

1978 • 71 citations

The release of amino acids from nerve during stimulation

1966 • 71 citations

Toxicity of naturally occuring purine deoxyribonucleosides

1980 • 71 citations

Uptake of adenosine triphosphate by isolated adrenal chromaffin granules: A carrier-mediated transport

1977 • 70 citations

Effects of neuronal polypeptides on intestinal smooth muscle; a comparison with non-adrenergic, non-cholinergic nerve stimulation and ATP

1979 • 70 citations

Synaptic repression at neuromuscular junctions.

1980 • 70 citations

THE SPECIFICITY OF 5'-NUCLEOTIDASE IN THE BRAIN OF THE MOUSE

1965 • 70 citations

RELEASE OF ³H‐PURINES FROM [³H]‐ADENINE LABELLED RABBIT KIDNEY FOLLOWING SYMPATHETIC NERVE STIMULATION, AND ITS INHIBITION BY α‐ADRENOCEPTOR BLOCKADE

1978 • 69 citations

Regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*

1975 • 69 citations

Specific binding of 2-[³H]chloroadenosine to rat brain cortical membranes

1980 • 69 citations

KINETICS OF ADENOSINE UPTAKE INTO ASTROCYTES

1978 • 68 citations

ANTAGONISM OF ADENOSINE 5′‐TRIPHOSPHATE‐INDUCED RELAXATION BY 2‐2′‐PYRIDYLISATOGEN IN THE TAENIA OF GUINEA‐PIG CAECUM

1975 • 67 citations

COMPARATIVE PHARMACOLOGICAL AND HISTOCHEMICAL EVIDENCE FOR PURINERGIC INHIBITORY INNERVATION OF THE PORTAL VEIN OF THE RABBIT, BUT NOT GUINEA‐PIG

1979 • 67 citations

X-linked recessive (Duchenne) muscular dystrophy (DMD) and purine metabolism: Effects of oral allopurinol and adenylate

1978 • 66 citations

Effects of coronary vasodilator drugs on the uptake and release of adenosine in cardiac cells

1979 • 66 citations

Potentiation of Ca2+-dependent K+ activation by theophylline is independent of cyclic nucleotide elevation

1979 • 65 citations

Evidence for the uptake of ATP by rat soleus muscle in vitro

1970 • 64 citations

Purinergic Transmission

1975 • 64 citations

Release and transfer of [3H]adenosine derivatives in the cholinergic septal system

1977 • 64 citations

The non-adrenergic, inhibitory innervation of the guinea-pig gallbladder

1978 • 63 citations

Displacement of [3H] diazepam binding in rat brain by dipyridamole and by 1-methylisoguanosine, a marine natural product with muscle relaxant activity

1980 • 63 citations

Drugs and Central Synaptic Transmission

1976 • 62 citations

A physiological correlate of disuse-induced sprouting at the neuromuscular junction

1979 • 61 citations

Purine and pyrimidine mononucleotides depolarise neurones of explanted amphibian sympathetic ganglia

1977 • 61 citations

Synaptosomes and cell separation

1976 • 61 citations

Control of cell division: a unifying hypothesis.

1975 • 61 citations

Evidence against presynaptic α-adrenoreceptor modulation of cardiac sympathetic transmission

1980 • 61 citations

Characterization of [3H]adenosine binding to fat cell membranes.

1978 • 60 citations

Physiological roles of adenosine derivatives which are released during neurotransmission in mammalian brain.

1978 • 60 citations

Cyclic adenosine 3′,5′-monophosphate role in the physiology and pharmacology of the central nervous system

1975 • 59 citations

Morphine increases depolarization induced purine release from rat cortical slices

1978 • 59 citations

Depolarization‐Evoked Accumulation of Cyclic AMP in Brain Slices: The Requisite Intermediate Adenosine is Not Derived from Hydrolysis of Released ATP

1980 • 58 citations

Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclase

1979 • 58 citations

Cyclic nucleotides in the nervous system

1978 • 57 citations

Specific binding of 3H-adenosine to rat brain membranes

1979 • 57 citations

SINGLE PULSE STIMULATION OF GUINEA‐PIG VAS DEFERENS AND THE PRESYNAPTIC RECEPTOR HYPOTHESIS

1979 • 57 citations

Inhibitory action of adenosine and adenosine analogs on neutrotransmission in the olfactory cortex slice of guinea pig — Structure-activity relationships

1980 • 57 citations

The Formation of Adenosine in Rabbit Liver and Its Possible Role as a Direct Precursor of Erythrocyte Adenine Nucleotides

1974 • 56 citations

Human Muscular Dystrophy as an Aberration of the Connective Tissue

1959 • 56 citations

Adenosine as a constituent of the brain and of isolated cerebral tissues, and its relationship to the generation of adenosine 3′:5′-cyclic monophosphate

1977 • 56 citations

Characteristics of the release of adenosine from slices of rat cerebral cortex.

1980 • 55 citations

A potassium contribution to the response of the barnacle photoreceptor.

1977 • 55 citations

Evidence that most noradrenaline is stored without ATP in sympathetic large dense core nerve vesicles

1974 • 55 citations

TRANSPORT OF NUCLEOSIDES^*

1975 • 53 citations

Elevation of cyclic amp in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines

1977 • 52 citations

Inhibition of animal and invertebrate cell growth by naturally occurring purine bases and ribonucleosides

1980 • 52 citations

Adrenergic antagonists and the presynaptic receptor hypothesis in vascular tissue.

1979 • 51 citations

EFFECTS OF SYMPATHOMIMETIC AMINES ON ⁴⁵Ca EFFLUX FROM LIVER SLICES

1976 • 51 citations

ADENOSINE UPTAKE BY CHOLINERGIC SYNAPTOSOMES FROM TORPEDO ELECTRIC ORGAN

1978 • 50 citations

Antagonism of the effects of purinergic nerve stimulation and exogenously applied ATP on the guinea-pig taenia coli by 2-substituted imidazolines and related compounds

1973 • 50 citations

IDENTIFICATION OF SEPARATE RECEPTORS FOR ADENOSINE AND ADENOSINE 5′‐TRIPHOSPHATE IN CAUSING RELAXATIONS OF THE ISOLATED TAENIA OF THE GUINEA‐PIG CAECUM

1976 • 49 citations

Depolarisation-Induced Release of ATP from Cortical Synaptosomes Is Not Associated with Acetylcholine Release

1980 • 48 citations

DISSIMILARITY BETWEEN THE RESPONSES TO ADENOSINE TRIPHOSPHATE OR ITS RELATED COMPOUNDS AND NON‐ADRENERGIC INHIBITORY NERVE STIMULATION IN THE LONGITUDINAL SMOOTH MUSCLE OF PIG STOMACH

1977 • 48 citations

Is adenosine the mediator of opiate action on neuronal firing rate?

1979 • 48 citations

Parallel investigations of the effects of adenosine on evoked potentials and cyclic AMP accumulation in hippocampus slices of the rat

1979 • 47 citations

BLOCKADE OF STRIATAL NEURONE RESPONSES TO MORPHINE BY AMINOPHYLLINE: EVIDENCE FOR ADENOSINE MEDIATION OF OPIATE ACTION

1980 • 45 citations

Inhibition of lymphocyte-mediated cytolysis by adenosine analogs

1978 • 44 citations

Incorporation of adenosine into ATP: formation of compartmentalized ATP.

1976 • 43 citations

The subcellular distribution of 5′-nucleotidase activity in mouse cerebellum

1977 • 43 citations

Limitations of presynaptic adrenoceptor theory: the characteristics of the effects of noradrenaline and phenoxybenzamine on stimulation-induced efflux of [3H]noradrenaline in vas deferens.

1980 • 42 citations

Interactions of morphine, adenosine, adenosine triphosphate and phosphodiesterase inhibitors on the field-stimulated guinea-pig ileum.

1975 • 42 citations

NEUROBLASTOMA CELL ADENYLATE CYCLASE: DIRECT ACTIVATION BY ADENOSINE AND PROSTAGLANDINS¹

1976 • 42 citations

The action of adenosine on noradrenergic neuronal inhibition induced by stimulation of locus coeruleus

1980 • 41 citations

Glutamate- and veratridine-elicited accumulations of cyclic AMP in brain slices: a role for factors which potentiate adenosine-responsive systems

1980 • 41 citations

PURINE ANTAGONISTS IN THE IDENTIFICATION OF ADENOSINE‐RECEPTORS IN GUINEA‐PIG TRACHEA AND THE ROLE OF PURINES IN NON‐ADRENERGIC INHIBITORY NEUROTRANSMISSION

1980 • 41 citations

RELAXATION OF GUINEA‐PIG FUNDIC STRIP BY ADENOSINE, ADENOSINE TRIPHOSPHATE AND ELECTRICAL STIMULATION: LACK OF ANTAGONISM BY THEOPHYLLINE OR ATP TREATMENT

1979 • 39 citations

An Analysis of Nucleotides and Catecholamines in Bovine Medullary Granules by Anion Exchange High Pressure Liquid Chromatography and Fluorescence

1977 • 38 citations

CYTOKININS AS CHEMOTHERAPEUTIC AGENTS^*

1975 • 38 citations

Induction of Stalk and Spore Cell Differentiation by Cyclic AMP in Slugs of Dictyostelium discoideum

1978 • 37 citations

The actions of adenosine and various nucleosides and nucleotides on the isolated toad spinal cord

1978 • 37 citations

Release of Adenine Nucleotide from Nerve Axons

1964 • 37 citations

An electrophysiological demonstration of a synergistic interaction between norepinephrine and adenosine in the cerebral cortex

1978 • 36 citations

Formation, accumulation and release of adenosine 3′,5′-monophosphate induced by histamine in the superior cervical ganglion of the rat in vitro

1974 • 36 citations

Bidirectional movement of label and transneuronal transport phenomena after injection of [3H]adenosine into the central nervous system

1976 • 36 citations

Interrelationships Between Phosphates and Calcium in Bioelectric Phenomena

1966 • 35 citations

Catecholamines and adenine nucleotide material in effluent from stimulated adrenal medulla and spleen

1970 • 35 citations

Studies on the relationship between Ca2+ efflux from mitochondria and the release of amino acid neurotransmitters

1980 • 35 citations

Abnormal adenine metabolism of erythrocytes in Duchenne and myotonic muscular dystrophy

1977 • 34 citations

Release of [14C]adenosine derivatives from superfused synaptosome preparations. Effects of depolarizing agents and metabolic inhibitors

1980 • 34 citations

Saturable binding of adenosine to the dog heart microsomal fraction: competitive inhibition by aminophylline.

1979 • 34 citations

The mode of coupling of adenylate cyclase to hormone receptors and its modulation by GTP

1978 • 33 citations

Absence of adenine nucleotide release from autonomic ganglion

1974 • 33 citations

Direction and specificity of the axonal and transcellular transport of nucleosides

1978 • 33 citations

Membrane response to 1-methyladenine requires the presence of the nucleus

1979 • 32 citations

Adenine mononucleotides and their metabolites liberated from and applied to isolated tissues of the mammalian brain

1977 • 32 citations

Potentiation by dipyridamole of the inhibition of guinea-pig ileum twitch response caused by adenine derivatives.

1978 • 31 citations

pH and temperature dependence of adenosine uptake in human erythrocytes

1978 • 31 citations

INTERACTIONS BETWEEN THE EFFECTS OF α‐ AND β‐ADRENOCEPTOR AGONISTS AND ADENINE NUCLEOTIDES ON THE MEMBRANE POTENTIAL OF CELLS IN GUINEA‐PIG LIVER SLICES

1977 • 31 citations

THEOPHYLLINE ANTAGONIZES SOME EFFECTS OF PURINES IN THE INTESTINE BUT NOT THOSE OF INTRAMURAL INHIBITORY NERVE STIMULATION

1979 • 30 citations

Structure activity relations for inhibition of neurotransmission in rat vas deferens by adenosine

1978 • 30 citations

Uptake and release of adenosine by cultured astrocytoma cells

1979 • 30 citations

The effects of AMP on the potential of rat cerebral cortical neurones

1976 • 30 citations

Adenine nucleotides in cholinergic transmission: presynaptic aspects.

1978 • 29 citations

Extended roles in the brain for second-messenger systems

1977 • 29 citations

4‐AMINOPYRIDINE BLOCKADE OF NEURONAL DEPRESSANT RESPONSES TO ADENOSINE TRIPHOSPHATE

1980 • 29 citations

Evaluation of the effects of adenosine on hepatic and adipocyte adenylate cyclase under conditions where adenosine is not generated endogenously.

1979 • 28 citations

Release of radioactive purines from cat nictitating membrane labeled with 3H-adenine

1979 • 28 citations

Neuronal and non-neuronal components in the overflow of labelled adenyl compounds from guinea-pig taenia coli

1978 • 28 citations

High affinity binding of 2-chloroadenosine to rat brain synaptic membranes

1980 • 27 citations

Effects of electrical stimulation on the efflux of l-glutamate from peripheral nerve in vitro

1971 • 27 citations

Presynaptic depression of synaptic response of Renshaw cells by adenosine 5′-monophosphate

1977 • 27 citations

2'-deoxyadenosine-3'-monophosphate: A naturally occurring inhibitor of adenylate cyclase in amphibian and mammalian cells

1976 • 26 citations

THE INHIBITORY MATERIAL IN EXTRACTS FROM THE BOVINE RETRACTOR PENIS MUSCLE IS NOT AN ADENINE NUCLEOTIDE

1979 • 26 citations

The Interaction between Caffeine and Calcium in the Desensitization of Muscle Postjunctional Membrane Receptors

1972 • 26 citations

Evidence for two adenine derivative receptors in rat ileum which are not involved in the nonadrenergic, noncholinergic response

1979 • 26 citations

Methylxanthines modulate adenosine release from slices of cerebral cortex

1981 • 24 citations

Focal lesions of muscle in peripheral vascular disease

1977 • 24 citations

Filamentous protein model for cyclic AMP-mediated cell regulatory mechanisms

1975 • 24 citations

Neuronal responses to extracellularly applied cyclic AMP: Role of the adenosine receptor

1978 • 23 citations

Evidence for phosphate as a mediator of functional hyperaemia in skeletal muscles

1977 • 23 citations

THE DEVELOPMENT OF TACHYPHYLAXIS TO ELECTRICAL STIMULATION IN GUINEA‐PIG ILEAL LONGITUDINAL MUSCLES AND THE POSSIBLE PARTICIPATION OF ADENOSINE AND ADENINE NUCLEOTIDES

1978 • 23 citations

Efflux of Cyclic Nucleotides from Rat Pineal: Release of Guanosine 3′,5′-Monophosphate from Sympathetic Nerve Endings

1977 • 23 citations

Biochemical and electropharmaceutical studies with tricyclic antidepressants in rat and guinea-pig cerebral cortex

1978 • 23 citations

Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex

1979 • 23 citations

Coronary vasoactivity of adenosine covalently linked to polylysine

1977 • 21 citations

Transport of purine nucleotides and nucleosides by in vitro rabbit ileum.

1977 • 21 citations

Translocation of neural modulators a second category of nerve signal

1976 • 21 citations

THE STABILIZING ACTIONS OF ADENOSINE TRIPHOSPHATE AND RELATED NUCLEOTIDES ON CALCIUM-DEFICIENT NERVE.

1964 • 21 citations

Cyclic AMP-induced changes in protein synthesis in a cellular slime mould, Polysphondylium pallidum

1975 • 21 citations

The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by adrenaline, ouabain and Mn⁺⁺

1973 • 20 citations

Phosphate efflux and oxygen consumption in small non‐myelinated nerve fibres at rest and during activity

1979 • 19 citations

mRNA Transcription linked to the Morphological and Plasma Membrane Changes induced by Cyclic AMP in Tumour Cells

1973 • 19 citations

Possible Roles for Purine Compounds in Neuronal Adaptation

1978 • 18 citations

Ionic and nucleotide cofactor requirements for uptake of [3H]norepinephrine by rat brain synaptic vesicle preparations.

1978 • 18 citations

Adenosine promoted accumulation of adenosine 3′,5′-monophosphate in rabbit vagus nerve

1976 • 17 citations

5-Nucleotidase in Normal and Diseased Human Skeletal Muscle

1958 • 17 citations

Is presynaptic acetylcholine release accompanied by the secretion of the synaptic vesicles contents?

1978 • 17 citations

Axonal transport of [3H]adenosine in visual and somatosensory pathways

1977 • 16 citations

Centrally-acting drugs and related compounds examined for action on output of adenine derivatives from superfused tissues of the brain

1976 • 15 citations

ATP in cholinergic nerves: Evidence for the axonal transport of a stable pool

1978 • 15 citations

High Concentrations of Calcium Prevent the Inhibition of Postsynaptic Potentials and the Accumulation of Cyclic AMP Induced by Adenosine in Brain Slices

1976 • 15 citations

Induction of differentiation of murine erythroleukemia cells by aminonucleoside of puromycin and inhibition of this induction by purines and purine derivatives.

1980 • 15 citations

Effects of adenosine and related compounds on an inhibitory process in rat cerebral cortex

1980 • 15 citations

Uptake and metabolism of purine nucleosides and nucleotides in isolated frog skeletal muscle

1977 • 14 citations

Exocytotic release of noradrenaline from synaptosomes

1980 • 14 citations

Filamentous protein model for cyclic AMP-mediated cell regulatory mechanisms

1975 • 14 citations

Relative ‘trophic’ influences of excitatory and inhibitory innervation of locust skeletal muscle fibres

1979 • 13 citations

Adenosine and related compounds do not affect nerve terminal excitability in rat CNS

1980 • 13 citations

Compartmentation of an ATP substrate pool for histamine and adrenaline sensitive adenylate cyclase in rat superior cervical ganglia

1975 • 13 citations

Uptake and release of adenosine in isolated rat fat cells

1979 • 13 citations

Neuronal (Na+,K+)-ATPase and the release of purines from mouse and rat cerebral cortex

1980 • 12 citations

Cyclic 3′, 5′‐nucleotides in extracellular fluids of neural systems

1977 • 12 citations

Natural occurrence of an inhibitor of mammalian cell growth in human and mouse cells of normal and tumor origin.

1976 • 12 citations

Presynaptic α‐receptors do not depress the secretion of ³H‐noradrenaline induced by veratridine

1979 • 11 citations

Inhibition of microbial growth by naturally-occuring purine bases and ribonucleosides

1980 • 11 citations

A different mode of action of potassium ions and veratridine on the formation of cyclic adenosine monophosphate in the cerebral cortex

1978 • 9 citations

Application of Adenosine Triphosphate and Related Compounds to Mammalian Striated and Smooth Muscle

1944 • 9 citations

Disorders of Purine and Pyrimidine Metabolism

1978 • 9 citations

Purine salvage pathways for the biosynthesis in vitro of adenine nucleotides in the guinea pig vas deferens

1978 • 8 citations

K+ and Na+ activation of cerebellar 5′-nucleotidase

1980 • 7 citations

Interactions between guanine derivatives and norepinephrine on neurones of the mammalian cerebral cortex

1978 • 6 citations

Disorders of Purine and Pyrimidine Metabolism

1979 • 6 citations

New Steps in Studying the Mechanism of Cholinergic Inhibition

1968 • 5 citations

The adenylcyclase complex: A model of its mechanism of action in relation to the α-and β-adrenergic receptors

1972 • 5 citations

Evolution of Cholinergic Transmission

1968 • 5 citations

CHEMOKINESIS OF RAT POLYMORPHONUCLEAR LEUCOCYTES AND THE EFFECT OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE

1980 • 5 citations

Postsynaptic facilitatory effects of theophylline on amphibian neuromyal transmission.

1978 • 5 citations

Horizons in clinical pharmacology

1976 • 4 citations

Modulation of postjunctional cholinergic sensitivity of rat diaphragm muscle by cyclic adenosine monophosphate

1976 • 4 citations

Hormone Receptors, Cyclic Nucleotides, and Control of Cell Function

1976 • 3 citations

Relationship Between Excitation of Vagal Inhibitory Neurons and Nucleoside Release: Estimation by Paper Chromatography.

1978 • 3 citations

Hypoxanthine—Guanine Phosphoribosyltransferase Activity in Blood and Skeletal Muscles of Normal and Dystrophic Mice

1978 • 3 citations

The neuromuscular and vascular hypotheses of muscular dystrophy: A possible link via adenine nucleotides and phosphate

1979 • 3 citations

Hormone Receptors, Cyclic Nucleotides, and Control of Cell Function

1979 • 2 citations

Deleted Work

1955 • 0 citations