Toxicity of naturally occuring purine deoxyribonucleosides

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

Regulation of Mammalian Deoxyribonucleotide Biosynthesis by Nucleotides as Activators and Inhibitors

1966 • 395 citations

Deoxyriboside Control and Synchronization of Mitosis

1962 • 386 citations

Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine.

1979 • 277 citations

Actions of Chemicals on Dividing Cells

1967 • 235 citations

Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease

1978 • 230 citations

Mammalian Deoxynucleoside Kinases

1968 • 210 citations

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

1978 • 209 citations

Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.

1976 • 209 citations

Studies on a Possible Regulatory Mechanism for the Biosynthesis of Deoxyribonucleic Acid

1961 • 206 citations

Actions of chemicals on dividing cells

1966 • 203 citations

Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity

1979 • 178 citations

Purification and Properties of Adenosine Kinase from Human Tumor Cells of Type H. Ep. No. 2

1967 • 171 citations

In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

1979 • 168 citations

S -Adenosylhomocysteine Hydrolase Is an Adenosine-Binding Protein: a Target for Adenosine Toxicity

1978 • 167 citations

Some Properties of Partially Purified Mammalian Adenosine Kinase

1967 • 159 citations

Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: Genetic model for immunodeficiency disease

1979 • 158 citations

Deoxyguanosine toxicity in a mouse T lymphoma: Relationship to purine nucleoside phosphorylase-associated immune dysfunction

1978 • 144 citations

Synchronization of mammalian cells in vitro by inhibition of the DNA synthesis

1966 • 141 citations

Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides.

1979 • 140 citations

The Ability of Purine and Thymine Derivatives and of Glycine to Support the Growth of Mammalian Cells in Culture

1959 • 136 citations

Synthesis of DNA during meiosis.

1966 • 135 citations

Deoxycytidine Kinase

1970 • 133 citations

Studies concerning the inhibition of cellular reproduction by deoxyribonucleosides

1963 • 124 citations

Deoxycytidine Kinase

1970 • 122 citations

Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation.

1969 • 121 citations

A ROLE FOR PURINE METABOLISM IN THE IMMUNE RESPONSE: ADENOSINE-DEAMINASE ACTIVITY AND DEOXYADENOSINE CATABOLISM

1978 • 121 citations

The inhibition of repair in UV irradiated human cells

1977 • 119 citations

The effect of deoxyadenosine and cytosine arabinoside on the chromosomes of human leukocytes in vitro

2009 • 108 citations

Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function

1979 • 106 citations

Further studies on the effect of deoxyadenosine on the accumulation of deoxyadenosine triphosphate and inhibition of deoxyribonucleic acid synthesis in Ehrlich ascites tumor cells in vitro

1962 • 96 citations

Specificity of adenosine deaminase toward adenosine and 2′-deoxyadenosine analogues

1966 • 94 citations

Cell viability and nucleic acid metabolism after exposure of HeLa cells to excess thymidine and deoxyadenosine

1965 • 92 citations

Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol

1979 • 89 citations

Alterations leading to increased ribonucleotide reductase in cells selected for resistance to deoxynucleosides

1974 • 89 citations

Induction synchrony in the fission yeast Schizosaccharomyces pombe

1971 • 88 citations

From deoxynucleotides to DNA synthesis.

1978 • 82 citations

On the effect of some adenine derivatives on the incorporation in vitro of isotopically labelled compounds into the nucleic acids of ehrlich ascites tumor cells

1959 • 81 citations

Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency

1978 • 78 citations

Properties of Diploid Cell Strains Developed from Patients with an Inherited Abnormality of Uridine Biosynthesis

1964 • 77 citations

Studies of meiosis in vitro

1967 • 76 citations

The uptake of nucleosides by cells in culture I. Inhibition by heterologous nucleosides

1969 • 72 citations

Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts.

1970 • 60 citations

Deoxyribonucleotide Pools in Mouse‐Fibroblast Cell Lines with Altered Ribonucleotide Reductase

1976 • 58 citations

Regulatory mechanisms in the synthesis of deoxyribonucleic acid in vitro

1960 • 58 citations

The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes

1975 • 58 citations

Formation in vitro of deoxyadenosine triphosphate from deoxyadenosine in Ehrlich ascites cells

1960 • 54 citations

Mutants of Chinese hamster cells resistant to adenosine

1975 • 53 citations

EFFECT OF HYDROXYUREA AND OTHER INHIBITORS OF DNA SYNTHESIS ON VICIA CHROMOSOMES PREVIOUSLY EXPOSED TO X-RAYS OR TO RADIOMIMETIC CHEMICALS

2009 • 52 citations

Mammalian Deoxynucleoside Kinases

1971 • 51 citations

Inhibition of growth rate and deoxynucleoside triphosphate concentrations in cultured leukemia L1210 cells.

1976 • 51 citations

Studies on the mechanism regulating periodic DNA synthesis in synchronized cultures of Alcaligenes fecalis

1960 • 50 citations

Some substrates and inhibitors of adenosine deaminase

1965 • 48 citations

Phosphorylation of ribavirin by deoxyadenosine kinase from rat liver. Differentiation between adenosine and deoxyadenosine kinase

1974 • 47 citations

Deoxyadenosine as an inducer of chromosomal aberrations in Vicia faba

1963 • 46 citations

Inhibition of Deoxyribonucleic Acid Synthesis in Chick Embryos by Deoxyadenosine

1960 • 46 citations

Studies on 1‐β‐D‐Arabinofuranosyl‐cytosine‐Resistant Mutants of Chinese‐Hamster Fibroblasts

1973 • 46 citations

The Biosynthesis of Deoxyribose

1967 • 45 citations

Purification and Properties of Adenosine Kinase from Dried Brewer’s Yeast

1971 • 44 citations

The mechanism of recombination in Chlamydomonas reinhardi I. The influence of inhibitors of protein synthesis on intergenic recombination

1967 • 44 citations

Deoxyadenosine metabolism and toxicity in cultured L5178Y cells.

1977 • 44 citations

“Bound” and “Free” Catecholamines in the Brain

1960 • 42 citations

Structural requirements for activity of nucleosides as substrates for adenosine kinase: orientation of substituents on the pentofuranosyl ring.

1975 • 42 citations

Purification of deoxycytidine kinases from two P815 murine neoplasms and their separation from deoxyguanosine kinase

1976 • 42 citations

Effects of chromosome-breaking purine derivatives on nucleic acid synthesis and on the levels of adenosine 5′-triphosphate and deoxyadenosine 5′-triphosphate in bean root tips

1965 • 39 citations

Further studies on the inhibition of nucleic acid biosynthesis by azathymidine and by deoxyadenosine

1959 • 39 citations

Toxicities of adenosine and 2'-deoxyadenosine in l cells treated with inhibitors of adenosine deaminase

1977 • 38 citations

Comparison of the cytidine 5'-diphosphate and adenosine 5'-diphosphate reductase activities of mammalian ribonucleotide reductase.

1975 • 38 citations

Influence of Coformycin on the Cytostatic Activity of 9-β-D-Arabinofuranosyladenine and Adenosine in Mouse L5178y Cells

1978 • 36 citations

Dietary utilization of DNA and its derivatives by Drosophila melanogaster (Meig.)

1963 • 35 citations

Purine and pyrimidine salvage in a clonal Drosophila cell line

1977 • 34 citations

The mechanism of recombination in Chlamydomonas reinhardi II. The influence of inhibitors of DNA synthesis on intergenic recombination

1967 • 33 citations

Regulation by nucleotides of the activity of partially purified ribonucleotide reductase from rat embryos.

1968 • 33 citations

Effects of 3′deoxyadenosine (cordycepin) and 2′deoxyadenosine on nucleoside transport, macromolecular synthesis, and replication of cultured Novikoff hepatoma cells

1971 • 31 citations

Mammalian Deoxynucleoside Kinases

1971 • 31 citations

The effect of some purine deoxyribosides on the incorporation of [14C]formate and [32P]orthophosphate into DNA of ascites tumor cells in vitro

1960 • 31 citations

Acute effects of cytotoxic compounds on incorporation of precursors into DNA, RNA, and protein of HeLa monolayers

1965 • 27 citations

Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

1979 • 26 citations

Effects of physiological purines on the development of the chick embryo

1961 • 26 citations

Inhibition of macromolecular synthesis and of cell division in synchronized Tetrahymena

1962 • 26 citations

The Effect of Fluorodeoxyuridine and Deoxyadenosine on Growth and Morphogenesis of Ophiostoma multiannulatum

1964 • 25 citations

Characterization of the kinase(s) involved in the phosphorylation of - and -2'-deoxythioguanosine.

1972 • 24 citations

Mathematical simulation of the interaction of drugs that inhibit deoxyribonucleic acid biosynthesis.

1973 • 24 citations

EFFECTS OF ADENINE NUCLEOSIDES ON CHROMOSOMES, CELL DIVISION AND NUCLEIC ACID SYNTHESIS IN VICIA FABA

2009 • 24 citations

ON THE MECHANISM OF INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS IN EHRLICH ASCITES TUMOR CELLS BY DEOXYADENOSINE IN VITRO

1961 • 23 citations

Mechanism of Inhibition of Bacterial Growth by Adenine

1974 • 23 citations

Decreased DNA synthesis in mammalian cells

1974 • 22 citations

Phosphorylation of Adenosine and Deoxyadenosine in Ehrlich Ascites Carcinoma Cells Resistant to 6-(Methylmercapto)purine Ribonucleoside

1972 • 22 citations

Potentiation by guanine nucleosides of the growth-inhibitory effects of adenosine analogs on L1210 and sarcoma 180 cells in culture.

1976 • 21 citations

The formation of deoxyadenosine triphosphate in ascites-tumour cells in vitro and its effect on deoxyribonucleic acid synthesis

1963 • 21 citations

Selective Inhibition of Deoxyribonucleic Acid Synthesis by 2-Deoxyadenosine in the Blue-Green Bacterium Agmenellum quadruplicatum

1972 • 20 citations

Studies on 1-β-d-arabinofuranosyl-cytosine (Ara-C) resistant mutants of Chinese hamster fibroblasts

1974 • 20 citations

Molecular events in replication of nuclei*1, *2

1963 • 19 citations

Hydroxyurea: Effect on Vicia chromosomes previously exposed to X-rays or to radiomimetic chemicals

1967 • 19 citations

Interphase sensitivity to the chromosome-breaking effect of 2′-deoxyadenosine: An autoradiographic study

1967 • 18 citations

Survival of Drosophila melanogaster larvae on defined medium supplemented with naturally occurring nucleosides and nucleic acid bases

1977 • 18 citations

Relationships among purine nucleoside metabolism, adenosine triphosphate catabolism, and glycolysis in human erythrocytes

1979 • 16 citations

The regulatory properties of deoxyadenosine kinase

1968 • 16 citations

2'-Deoxyadenosine and A23187 as Agents for Inducing Synchrony in the Budding Yeast, Kluyveromyces fragilis

1975 • 16 citations

Effect of specific inhibitors on mitochondrial DNA replication in HeLa cells

1974 • 16 citations

The inhibition of herpes simplex virus multiplication by nucleosides

1965 • 15 citations

Mechanism of inhibition of Crithidia fasciculata by adenosine and adenosine analogs

1978 • 15 citations

DNA Synthesis during Maturation of Starfish Oocytes

1972 • 15 citations

Effects on HeLa cell division of physiologic deoxyribonucleosides and deoxyribonucleotides.

1966 • 15 citations

NUTRITION AND METABOLISM OF MARINE BACTERIA VII

1958 • 13 citations

Use of Escherichia coli Mutants to Evaluate Purines, Purine Nucleosides, and Analogues

1973 • 13 citations

Inhibition of Growth of Chick Embryo by Inhibition of Deoxycytidylate Deaminase

1963 • 12 citations

Enzyme synthesis and potential during induction synchrony in the fission yeast Schizosaccharomyces pombe

1973 • 12 citations

The effect of exogenous deoxyribonucleosides on thymidine incorporation in T4‐infected cells

1978 • 12 citations

Stimulation of thymidylate kinase and deoxycytidylate deaminase activities of chang cells by deoxyadenosine

1969 • 12 citations

The Pool Sizes of Adenine Nucleotides in Exponentially Growing, Stationary Phase and 2'-Deoxyadenosine-synchronized Cultures of Schizosaccharomyces pombe 972 h-

1978 • 11 citations

Pyrimidine nucleotide metabolism in L5178Y murine leukemia cells: deoxycytidine protection from deoxyguanosine toxicity.

1976 • 11 citations

Enhancement by caffeine of the growth inhibitory effects of antimetabolites in lymphoma L5178Y cells

1977 • 11 citations

Relationship Between [8- ¹⁴ C]Adenosine Transport and Growth Inhibition in Neurospora crassa Strain ad-8

1974 • 11 citations

Chemical Inhibitors of Theiler's Virus.

1956 • 11 citations

Metabolism of Deoxyribonucleotides<subtitle>IV. Purification and Properties of Deoxycytidine Kinase of Calf Thymus<xref ref-type="fn" rid="fn1"><sup>*</sup></xref></subtitle>

1972 • 11 citations

Delays in prophase induced by adenosine 2-deoxyriboside and their relation with DNA synthesis

1970 • 10 citations

Intracellular formation of analogues of cyclic AMP

1975 • 9 citations

Growth inhibition of a Staphylococcus aureus aminopterin-derived thymineless mutant by exogenous nucleosides in the presence of thymine

1969 • 9 citations

Inhibition of DNA-Synthesis by Deoxyadenosine.

1958 • 9 citations

Deoxyguanosine, a potent cytokinesis inhibitor in plant cells

1974 • 8 citations

Some effects of deoxyribonucleosides on sea urchin egg development

1968 • 8 citations

Effects of Hydroxyurea and Deoxyadenosine on the Synthesis of Deoxycytidine Phosphate and on the Uptake of Nucleosides in Excised Root Tips of Vicia faba

1971 • 7 citations

Combinations of drugs which interact as inhibitors of DNA biosynthesis

1972 • 7 citations

Deoxyadenosine-induced stimulation of thymidine kinase activity of Chang cells

1968 • 6 citations

Viral Inhibitors of Biological Origin. II. A Viral Inhibitory Factor Obtained from E. coli 0111 and Inhibition of Viral Replication by Nucleic Acid Derivatives.

1964 • 6 citations

THE NUTRITIONAL REQUIREMENTS OF LACTOBACILLUS BIFIDUS AND LACTOBACILLUS LEICHMANNII

1953 • 6 citations

Enzymatic Reduction of Purine Ribonucleotides.

1963 • 5 citations

Inhibition of cell division and induction of chromosome aberrations in cultured Ehrlich ascites tumor cells by deoxyguanosine

1970 • 5 citations

Purine Ribonucleotide Reductase: End-Product Inhibition and Stimulation of a Mammalian Enzyme.

1967 • 5 citations

The Effect of Deoxyadenosine on Growing Cultures of Escherichia coli.

1963 • 5 citations

Interphase sensitivity to inhibition of DNA synthesis

1969 • 5 citations

Studies of inhibition of deoxynucleotide synthesis in chick embryos

1968 • 4 citations

Concerning the site of action of deoxyadenosine (deoxyadenosinetriphosphate) upon the synthesis of nucleic acids in the cancer cell

1968 • 4 citations

The effect of purine and pyrimidine compounds on the virus-host cell interation. I. The effect on interferon production and virus multiplication.

1968 • 4 citations

Effect of Deoxyguanosine on Skeletal Development in the Chick Embryo

1966 • 3 citations

Contribution to the Understanding of the Mechanism of Cytokinesis In Plant Cells: the Action of Deoxyguanosine On the Kinetics of A Root Meristem Cell Population

1978 • 3 citations

The Nutrition of a Lactobacillus acidophilus Variant Isolated from the Duodenum of a chick

1961 • 3 citations

Interaction in teratogenesis: Actinomycin D, puromycin and deoxyguanosine

1968 • 3 citations

Effects of nucleic acid and its related compounds on Yoshida sarcoma cells in vitro

1971 • 2 citations

Inhibitors of adenosine kinase.

1971 • 2 citations

Effect of 2′-Deoxyadenosine on Thymidine Utilization by Tradescantia Pollen Grains

1967 • 2 citations

Causes and conditions for the creation of nucleolar morphological changes with adenosine.

1970 • 2 citations

Metabolic effets of nucleosides in rat thymus cells in vitro

1971 • 2 citations

Effect of deoxyadenosine and cycloheximide on biogenesis of chromatin in pea root tips.

1973 • 1 citations