Loss of Transgelin in Breast and Colon Tumors and in RIE-1 Cells by Ras Deregulation of Gene Expression through Raf-independent Pathways

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

How cells read TGF-β signals

2000 • 1,843 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Specific protection against breast cancers by cyclin D1 ablation

2001 • 930 citations

Identifying differences in mRNA expression by representational difference analysis of cDNA

1994 • 904 citations

Understanding Ras: ‘it ain’t over ’til it’s over’

2000 • 785 citations

Ras and Rho GTPases

2000 • 779 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

Ras effectors

1996 • 445 citations

The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot

1998 • 441 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Ras and Rho regulation of the cell cycle and oncogenesis

2001 • 316 citations

A genome-wide survey of RAS transformation targets

2000 • 293 citations

Cellular Transformation and Malignancy Induced by ras Require c-jun

1996 • 283 citations

Analysis of the transcriptional program induced by Raf in epithelial cells

2001 • 255 citations

Induction of Apoptosis of Metastatic Mammary Carcinoma Cells In Vivo by Disruption of Tumor Cell Surface CD44 Function

1997 • 252 citations

Evidence for a Ras/Ral signaling cascade

1996 • 214 citations

Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene.

1993 • 175 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein.

1993 • 162 citations

Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor.

1988 • 154 citations

CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells

1998 • 149 citations

Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression

1992 • 147 citations

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

1996 • 142 citations

Fibroblast transgelin and smooth muscle SM22α are the same protein, the expression of which is down-regulated in many cell lines

1997 • 124 citations

Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study.

1976 • 118 citations

Two differentially expressed genes in normal human prostate tissue and in carcinoma.

1996 • 112 citations

Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-κB

2000 • 105 citations

Phenotypic analysis of ovarian carcinoma: Polypeptide expression in benign, borderline and malignant tumors

1997 • 91 citations

Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH2-terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun

1998 • 88 citations

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells.

1996 • 78 citations

Specific Induction of Apoptosis in P19 Embryonal Carcinoma Cells by Retinoic Acid and BMP2 or BMP4

1996 • 77 citations

Reversion of Ras transformed cells by Ets transdominant mutants.

1994 • 69 citations

NF-κB is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis

2000 • 69 citations

Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

1999 • 68 citations

Bone Morphogenetic Proteins Induce Apoptosis and Growth Factor Dependence of Cultured Sympathoadrenal Progenitor Cells

1998 • 63 citations

Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.

1991 • 61 citations

Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression.

1992 • 59 citations

Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization

1998 • 59 citations

Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells

1999 • 56 citations

Involvement of NH2-terminal Sequences in the Negative Regulation of Vav Signaling and Transforming Activity

1999 • 54 citations

Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras

1999 • 47 citations

Cloning and sequencing of cDNAs encoding the actin cross‐liking protein transgelin defines a new family of actin‐associated proteins

1994 • 46 citations

Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape.

1988 • 46 citations

Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor.

1992 • 44 citations

Reduced expression of the CXC chemokine hIRH/SDF-1α mRNA in hepatoma and digestive tract cancer

1997 • 43 citations

Neoplastic phenotype of gap-junctional intercellular communication–deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32

1998 • 43 citations

Ras- and Raf-induced Down-modulation of Non-muscle Tropomyosin Are MEK-independent

1998 • 37 citations

Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines.

2000 • 34 citations

Structure and Expression of the Human SM22 Gene, Assignment of the Gene to Chromosome 11, and Repression of the Promoter Activity by Cytosine DNA Methylation

1997 • 33 citations

Regulation of Inosine-5′-monophosphate Dehydrogenase Type II Gene Expression in Human T Cells

1997 • 32 citations

Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts.

1997 • 31 citations

SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. II. Changes in gap junctional intercellular communication

1998 • 30 citations

Inhibition of Fos- and Ras-induced transformation by mutant Fos proteins with structural alterations in functionally different domains.

1992 • 29 citations

BMP4- and RA-Induced Apoptosis Is Mediated through the Activation of Retinoic Acid Receptor α and γ in P19 Embryonal Carcinoma Cells

1998 • 22 citations

Serpin inhibitors of urokinase and thrombin in normal rat brain and the 9L brain tumor: evidence for elevated expression of protease nexin I-like inhibitor and a novel sodium dodecyl sulfate-activated tumor antithrombin.

1990 • 22 citations

Real-Time Three-Dimensional Ultrasound Methods for Shape Analysis and Visualization

2001 • 18 citations

Identification of ras-regulated genes by representational difference analysis

2001 • 5 citations

Oncogene-Directed Therapies

2002 • 4 citations