Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

An obesity-associated gut microbiome with increased capacity for energy harvest

2006 • 11,120 citations

Human gut microbes associated with obesity

2006 • 7,995 citations

Enterotypes of the human gut microbiome

2011 • 6,574 citations

Obesity alters gut microbial ecology

2005 • 5,818 citations

The gut microbiota as an environmental factor that regulates fat storage

2004 • 5,730 citations

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

2007 • 5,661 citations

Host-Bacterial Mutualism in the Human Intestine

2005 • 4,852 citations

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

2011 • 4,704 citations

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

2007 • 4,230 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Gut Microbiota in Health and Disease

2010 • 3,772 citations

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

2008 • 2,750 citations

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

2007 • 2,435 citations

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

2004 • 2,363 citations

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

2008 • 1,853 citations

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

2007 • 1,678 citations

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

2010 • 1,115 citations

Symbiotic gut microbes modulate human metabolic phenotypes

2008 • 1,103 citations

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

2006 • 1,019 citations

Human metabolic phenotype diversity and its association with diet and blood pressure

2008 • 1,012 citations

An African origin for the intimate association between humans and Helicobacter pylori

2007 • 938 citations

Pharmaco-metabonomic phenotyping and personalized drug treatment

2006 • 801 citations

Bile acid biosynthesis

1992 • 790 citations

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

2010 • 675 citations

A humanized gnotobiotic mouse model of host–archaeal–bacterial mutualism

2006 • 624 citations

New IBD genetics: common pathways with other diseases

2011 • 595 citations

Rapid and Noninvasive Metabonomic Characterization of Inflammatory Bowel Disease

2007 • 586 citations

Energy intake is associated with endotoxemia in apparently healthy men

2008 • 553 citations

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

2010 • 550 citations

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

2007 • 543 citations

Chemometrics in metabolomics—A review in human disease diagnosis

2009 • 539 citations

Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk

2011 • 436 citations

Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism

1996 • 435 citations

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

2009 • 415 citations

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

2008 • 413 citations

Phylogeny of the Defined Murine Microbiota: Altered Schaedler Flora

1999 • 360 citations

HELICOBACTER PYLORI AND GASTRIC CANCER

1993 • 357 citations

The end products of the metabolism of aromatic amino acids by clostridia

1976 • 353 citations

Statistical Heterospectroscopy, an Approach to the Integrated Analysis of NMR and UPLC-MS Data Sets: Application in Metabonomic Toxicology Studies

2005 • 326 citations

Diet-Induced Metabolic Improvements in a Hamster Model of Hypercholesterolemia Are Strongly Linked to Alterations of the Gut Microbiota

2009 • 326 citations

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

2008 • 323 citations

Recursive Segment-Wise Peak Alignment of Biological ¹H NMR Spectra for Improved Metabolic Biomarker Recovery

2008 • 313 citations

Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls

2010 • 301 citations

Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies

2010 • 278 citations

Top-Down Systems Biology Modeling of Host Metabotype−Microbiome Associations in Obese Rodents

2009 • 253 citations

Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats

2010 • 248 citations

Urine Metabolite Analysis Offers Potential Early Diagnosis of Ovarian and Breast Cancers

2010 • 234 citations

Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis

2008 • 231 citations

The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension

2006 • 229 citations

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens

2009 • 226 citations

Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype

2010 • 224 citations

Metabonomic and Microbiological Analysis of the Dynamic Effect of Vancomycin-Induced Gut Microbiota Modification in the Mouse

2008 • 221 citations

NMR Spectroscopic-Based Metabonomic Studies of Urinary Metabolite Variation in Acclimatizing Germ-Free Rats

2003 • 220 citations

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Urine

2010 • 219 citations

Urinary Metabonomic Study on Colorectal Cancer

2010 • 216 citations

The Microbe-Derived Short Chain Fatty Acid Butyrate Targets miRNA-Dependent p21 Gene Expression in Human Colon Cancer

2011 • 213 citations

Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice

2006 • 204 citations

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.

2002 • 195 citations

Metabolite profiling of fecal water extracts from human colorectal cancer

2008 • 181 citations

Characterization of Inflammatory Bowel Disease With Urinary Metabolic Profiling

2009 • 180 citations

Innate Immune Inflammatory Response against Enteric Bacteria Helicobacter hepaticus Induces Mammary Adenocarcinoma in Mice

2006 • 178 citations

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus -infected, Rag2 -deficient mice

2009 • 176 citations

Human faecal microbiota display variable patterns of glycerol metabolism

2010 • 171 citations

Why Do African Americans Get More Colon Cancer than Native Africans?

2007 • 159 citations

Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats

2008 • 156 citations

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

1997 • 153 citations

Urine Metabolomic Analysis Identifies Potential Biomarkers and Pathogenic Pathways in Kidney Cancer

2011 • 145 citations

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models

2007 • 145 citations

Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification

2009 • 130 citations

Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression

2009 • 128 citations

Role of dietary sulphate in the regulation of methanogenesis in the human large intestine.

1992 • 127 citations

Purification and Structural Characterization of 3-Hydroxypropionaldehyde and Its Derivatives

2003 • 120 citations

Helicobacter pylori and gastric cancer

2009 • 117 citations

Metabonomic Studies on the Physiological Effects of Acute and Chronic Psychological Stress in Sprague−Dawley Rats

2007 • 116 citations

Metabolite Profiling Identifies Candidate Markers Reflecting the Clinical Adaptations Associated with Roux-en-Y Gastric Bypass Surgery

2009 • 111 citations

Metabolic profiling reveals key metabolic features of renal cell carcinoma

2009 • 107 citations

GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium

2011 • 106 citations

Production of Skatole and para -Cresol by a Rumen Lactobacillus sp

1981 • 106 citations

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

2008 • 104 citations

Lipid Metabolism in Anaerobic Ecosystems

1991 • 100 citations

Metabonomics: systems biology in pharmaceutical research and development.

2004 • 98 citations

Fermentation potential of the gut microbiome: implications for energy homeostasis and weight management

2011 • 96 citations

Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.

1996 • 93 citations

Top‐down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model

2008 • 90 citations

A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease

2009 • 86 citations

Shifting from a Conventional Diet to an Uncooked Vegan Diet Reversibly Alters Fecal Hydrolytic Activities in Humans

1992 • 84 citations

Metabolic surgery: an evolution through bariatric animal models

2009 • 77 citations

Metabolic Assessment of Gradual Development of Moderate Experimental Colitis in IL-10 Deficient Mice

2009 • 73 citations

Profiling human gut bacterial metabolism and its kinetics using [U-¹³C]glucose and NMR

2009 • 73 citations

Global Metabolic Responses of NMRI Mice to an Experimental Plasmodium berghei Infection

2008 • 72 citations

An “Omics” based survey of human colon cancer

2010 • 70 citations

Lactobacillus farciminis treatment attenuates stress‐induced overexpression of Fos protein in spinal and supraspinal sites after colorectal distension in rats

2009 • 59 citations

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

2009 • 56 citations

Metabolomic Approach with LC-QTOF to Study the Effect of a Nutraceutical Treatment on Urine of Diabetic Rats

2010 • 52 citations

A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats

2010 • 52 citations

Polyamines Can Increase Resistance of Neisseria gonorrhoeae to Mediators of the Innate Human Host Defense

2010 • 47 citations

Profiles of ultraviolet-absorbing components of urine from autistic children, as obtained by high-resolution ion-exchange chromatography.

1976 • 41 citations

1H NMR-based Metabonomic Analysis of Metabolic Changes in Streptozotocin-induced Diabetic Rats

2010 • 35 citations

1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice

2010 • 34 citations

Urinary excretion of the uraemic toxin p-cresol in the rat: contribution of glucuronidation to its metabolization

2003 • 33 citations

Elie Metchnikoff's and Paul Ehrlich's impact on infection biology

2008 • 30 citations

Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.

2012 • 18 citations

Analysis of urinary metabolic profile in aging rats undergoing caloric restriction

2012 • 16 citations