Top-Down Systems Biology Modeling of Host Metabotype−Microbiome Associations in Obese Rodents

Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA

1993 • 11,277 citations

An obesity-associated gut microbiome with increased capacity for energy harvest

2006 • 11,120 citations

Human gut microbes associated with obesity

2006 • 7,995 citations

Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments

1954 • 6,078 citations

Obesity alters gut microbial ecology

2005 • 5,818 citations

Modified Spin-Echo Method for Measuring Nuclear Relaxation Times

1958 • 5,632 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Metagenomic Analysis of the Human Distal Gut Microbiome

2006 • 4,423 citations

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1999 • 3,649 citations

Orthogonal projections to latent structures (O‐PLS)

2002 • 2,195 citations

Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach

2005 • 2,123 citations

Determination of microbial diversity in environmental samples: pitfalls of PCR-based rRNA analysis

1997 • 2,046 citations

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

2007 • 1,678 citations

Direct Analysis of Genes Encoding 16S rRNA from Complex Communities Reveals Many Novel Molecular Species within the Human Gut

1999 • 1,472 citations

Sequence heterogeneities of genes encoding 16S rRNAs in Paenibacillus polymyxa detected by temperature gradient gel electrophoresis

1996 • 1,370 citations

OPLS discriminant analysis: combining the strengths of PLS‐DA and SIMCA classification

2006 • 1,301 citations

Rapid silver staining and recovery of PCR products separated on polyacrylamide gels.

1994 • 1,199 citations

Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment

1996 • 1,180 citations

Symbiotic gut microbes modulate human metabolic phenotypes

2008 • 1,103 citations

Evaluation of the bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP)

2008 • 1,093 citations

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

2003 • 1,075 citations

Variations of Bacterial Populations in Human Feces Measured by Fluorescent In Situ Hybridization with Group-Specific 16S rRNA-Targeted Oligonucleotide Probes

1998 • 1,064 citations

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

2006 • 1,019 citations

Human metabolic phenotype diversity and its association with diet and blood pressure

2008 • 1,012 citations

Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples

1995 • 975 citations

Recognition of bacterial glycosphingolipids by natural killer T cells

2005 • 918 citations

Gut microorganisms, mammalian metabolism and personalized health care

2005 • 917 citations

Culture-Independent Analysis of Gut Bacteria: the Pig Gastrointestinal Tract Microbiota Revisited

2002 • 861 citations

Pharmaco-metabonomic phenotyping and personalized drug treatment

2006 • 801 citations

Regulatory effects of bifidobacteria on the growth of other colonic bacteria

1994 • 693 citations

High resolution proton magnetic resonance spectroscopy of biological fluids

1989 • 615 citations

Use of 16S rRNA and rpoB Genes as Molecular Markers for Microbial Ecology Studies

2006 • 568 citations

Evaluation of the Orthogonal Projection on Latent Structure Model Limitations Caused by Chemical Shift Variability and Improved Visualization of Biomarker Changes in ¹H NMR Spectroscopic Metabonomic Studies

2004 • 543 citations

Infectious History

2000 • 491 citations

Comparisons of Different Hypervariable Regions ofrrsGenes for Use in Fingerprinting of Microbial Communities by PCR-Denaturing Gradient Gel Electrophoresis

2004 • 464 citations

A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model

2007 • 459 citations

Gut microbiota: a potential new territory for drug targeting

2008 • 449 citations

rpoB -Based Microbial Community Analysis Avoids Limitations Inherent in 16S rRNA Gene Intraspecies Heterogeneity

2000 • 424 citations

Using probiotics and prebiotics to improve gut health

2003 • 414 citations

High Resolution “Ultra Performance” Liquid Chromatography Coupled to oa-TOF Mass Spectrometry as a Tool for Differential Metabolic Pathway Profiling in Functional Genomic Studies

2005 • 411 citations

A 16S rRNA-targeted Probe for Detection of Lactobacilli and Enterococci in Faecal Samples by FluorescentIn SituHybridization

1999 • 378 citations

The challenges of modeling mammalian biocomplexity

2004 • 354 citations

Assessment of Analytical Reproducibility of ¹H NMR Spectroscopy Based Metabonomics for Large-Scale Epidemiological Research: the INTERMAP Study

2006 • 336 citations

An NMR‐based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

2000 • 319 citations

Recursive Segment-Wise Peak Alignment of Biological ¹H NMR Spectra for Improved Metabolic Biomarker Recovery

2008 • 313 citations

Plant Carbohydrate Scavenging through TonB-Dependent Receptors: A Feature Shared by Phytopathogenic and Aquatic Bacteria

2007 • 308 citations

Development of 16S rRNA-Based Probes for the Coriobacterium Group and the Atopobium Cluster and Their Application for Enumeration of Coriobacteriaceae in Human Feces from Volunteers of Different Age Groups

2000 • 308 citations

Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects

1984 • 273 citations

Metabonomic investigations in mice infected with Schistosoma mansoni : An approach for biomarker identification

2004 • 271 citations

Nutritional Metabonomics: Applications and Perspectives

2007 • 266 citations

Understanding Bias in Microbial Community Analysis Techniques due to rrn Operon Copy Number Heterogeneity

2003 • 249 citations

O2‐PLS for qualitative and quantitative analysis in multivariate calibration

2002 • 234 citations

Comparison of viable cell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria

2000 • 214 citations

Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

2000 • 214 citations

Analysis of the Rumen Bacterial Diversity under two Different Diet Conditions using Denaturing Gradient Gel Electrophoresis, Random Sequencing, and Statistical Ecology Approaches

2001 • 208 citations

Advantages and limitations of next‐generation sequencing technologies: A comparison of electrophoresis and non‐electrophoresis methods

2008 • 171 citations

Effects of carbon source on denitrification efficiency and microbial community structure in a saline wastewater treatment process

2008 • 169 citations

Human Metabolic Phenotypes Link Directly to Specific Dietary Preferences in Healthy Individuals

2007 • 160 citations

Proton NMR spectra of urine as indicators of renal damage. Mercury-induced nephrotoxicity in rats.

1985 • 156 citations

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models

2007 • 145 citations

Metabonomic Investigations of Aging and Caloric Restriction in a Life-Long Dog Study

2007 • 143 citations

Healthy gut microflora and allergy: factors influencing development of the microbiota

1999 • 141 citations

Nosocomial Infections Caused by Sphingomonas paucimobilis: Clinical Features and Microbiological Characteristics

1998 • 141 citations

A multi-analytical platform approach to the metabonomic analysis of plasma from normal and zucker (fa/fa) obese rats

2006 • 136 citations

High-Resolution Diffusion and Relaxation Edited One- and Two-Dimensional ¹H NMR Spectroscopy of Biological Fluids

1996 • 136 citations

Global metabolic responses of mice to Trypanosoma brucei brucei infection

2008 • 126 citations

The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS

2005 • 115 citations

A combined 1H NMR and HPLC–MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats

2005 • 107 citations

GC/MS analysis of the rat urine for metabonomic research

2007 • 86 citations

Measurement of Biomolecular Diffusion Coefficients in Blood Plasma Using Two-Dimensional ¹H−¹H Diffusion-Edited Total-Correlation NMR Spectroscopy

1997 • 84 citations

Effects of Probiotic Lactobacillus Paracasei Treatment on the Host Gut Tissue Metabolic Profiles Probed via Magic-Angle-Spinning NMR Spectroscopy

2007 • 84 citations

Differences in rDNA libraries of faecal bacteria derived from 10- and 25-cycle PCRs.

2002 • 83 citations

Transgenomic Metabolic Interactions in a Mouse Disease Model: Interactions of Trichinella spiralis Infection with Dietary Lactobacillus paracasei Supplementation

2006 • 73 citations

Zucker (fa/fa) Rat

1990 • 69 citations

Effect on Components of the Intestinal Microflora and Plasma Neuropeptide Levels of Feeding Lactobacillus delbrueckii , Bifidobacterium lactis , and Inulin to Adult and Elderly Rats

2006 • 59 citations

The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats

2006 • 57 citations

Increasing ecological inference from high throughput sequencing of fungi in the environment through a tagging approach

2008 • 50 citations

“FLIPSY”—A New Solvent-Suppression Sequence for Nonexchanging Solutes Offering Improved Integral Accuracy Relative to 1D NOESY

1996 • 49 citations

Metabolic Studies of a Family with Massive Formiminoglutamic Aciduria

1975 • 41 citations

A metabonomic study of strain‐ and age‐related differences in the Zucker rat

2007 • 41 citations

A novel lipid A from Halomonas magadiensis inhibits enteric LPS‐induced human monocyte activation

2005 • 30 citations

Identification of mouse submaxillary gland protein in mouse saliva and its binding to mouse oral bacteria

2002 • 28 citations

Effect of antibiotics on the bacterial population of the rabbit caecum

2007 • 23 citations

An outbreak of Halomonas phocaeensis sp. nov. bacteraemia in a neonatal intensive care unit

2007 • 19 citations

Comparisons of urinary creatinine, skeletal muscle mass, and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake, and deprived of food.

1989 • 13 citations

Prebiotics and the infant microbiota.

2005 • 3 citations