Statistical Heterospectroscopy, an Approach to the Integrated Analysis of NMR and UPLC-MS Data Sets: Application in Metabonomic Toxicology Studies

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1999 • 3,649 citations

Metabonomics: a platform for studying drug toxicity and gene function

2002 • 1,871 citations

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

2001 • 1,008 citations

Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis

2004 • 448 citations

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project

2003 • 386 citations

A Strategy for Identifying Differences in Large Series of Metabolomic Samples Analyzed by GC/MS

2004 • 334 citations

An NMR‐based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

2000 • 319 citations

Chemometric Models for Toxicity Classification Based on NMR Spectra of Biofluids

2000 • 277 citations

Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects

1984 • 273 citations

On‐Line LC‐NMR And Related Techniques

2002 • 263 citations

A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice

2005 • 217 citations

Metabonomic Investigations into Hydrazine Toxicity in the Rat

2001 • 183 citations

Combined HPLC, NMR Spectroscopy, and Ion-Trap Mass Spectrometry with Application to the Detection and Characterization of Xenobiotic and Endogenous Metabolites in Human Urine

1996 • 171 citations

The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine

1998 • 164 citations

Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences

2003 • 145 citations

Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism

2003 • 122 citations

Comparative metabonomics of differential hydrazine toxicity in the rat and mouse

2004 • 118 citations

Toxicity classification from metabonomic data using a density superposition approach: ‘CLOUDS’

2003 • 74 citations

Uroscopy in the 21st century: high-field NMR spectroscopy

1997 • 54 citations

Proton NMR spectroscopic studies on the metabolism and biochemical effects of hydrazine in vivo

1992 • 44 citations