The role of cholinergic projections from the nucleus basalis in memory

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

An introduction to cybernetics

1956 • 7,117 citations

The hippocampus as a cognitive map

1979 • 5,527 citations

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

1983 • 2,305 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Hippocampus, space, and memory

1979 • 2,033 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

Nucleus basalis and thalamic control of neocortical activity in the freely moving rat

1988 • 1,035 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase

1983 • 964 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Spatial memory and hippocampal function

1979 • 940 citations

The organization and some projections of cholinergic neurons of the mammalian forebrain

1982 • 821 citations

Alzheimer's Disease

1986 • 772 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

Activity of pallidal neurons during movement.

1971 • 734 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

The Physiological Basis of Memory

1969 • 657 citations

Memory and cognitive function in man

1977 • 624 citations

The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat

1980 • 617 citations

Memory Organization and Structure

1981 • 602 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

The origins of cholinergic and other subcortical afferents to the thalamus in the rat

1987 • 587 citations

Alzheimer's disease

1982 • 538 citations

Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats

1985 • 493 citations

Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases

1983 • 447 citations

Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats

1980 • 447 citations

Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat

1981 • 442 citations

Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments

1985 • 386 citations

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1

1983 • 371 citations

Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats

1987 • 352 citations

Animal models of Alzheimer's disease: experimental cholinergic denervation

1988 • 340 citations

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1983 • 332 citations

Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes

1989 • 325 citations

The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey

1979 • 314 citations

Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine

1985 • 305 citations

Substance P in the ascending cholinergic reticular system

1983 • 294 citations

Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis

1988 • 289 citations

Cholinergic activation of the electrocorticogram: Role of the substantia innominata and effects of atropine and quinuclidinyl benzilate

1984 • 273 citations

Memory impairments following basal forebrain lesions

1985 • 264 citations

Attention and the frontal cortex as examined by simultaneous temporal processing

1988 • 263 citations

Effects of hunger on the responses of neurons in the lateral hypothalamus to the sight and taste of food

1976 • 251 citations

Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies

1985 • 247 citations

Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis—II. Sensorimotor and learning impairments

1985 • 242 citations

Nucleus basalis magnocellularis and medial septal area lesions differentially impair temporal memory

1987 • 242 citations

Disruption of central cholinergic systems in the rat by basal forebrain lesions or atropine: Effects on feeding, sensorimotor behaviour, locomotor activity and spatial navigation

1985 • 242 citations

The septo-hippocampal system and cognitive mapping

1982 • 224 citations

Hippocampus: cognitive map or working memory?

1980 • 223 citations

Lesions of cholinergic forebrain nuclei: Changes in avoidance behavior and scopolamine actions

1982 • 218 citations

Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neurons.

1989 • 204 citations

Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs

1986 • 197 citations

Characteristics of memory impairment following lesioning of the basal forebrain and medial septal nucleus in rats

1987 • 194 citations

Neurophysiological analysis of brain-stimulation reward in the monkey

1980 • 190 citations

Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

1985 • 190 citations

The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional visual discrimination: Implications for cholinergic hypotheses of learning and memory

1987 • 183 citations

Modulation during learning of the responses of neurons in the lateral hypothalamus to the sight of food

1976 • 182 citations

Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals

1975 • 178 citations

Long-Term Neuropathological and Neurochemical Effects of Nucleus Basalis Lesions in the Rat

1987 • 169 citations

Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination: Differential effects on cholinergic mechanisms

1989 • 162 citations

Regulation of neocortical muscarinic receptors: effects of drug treatment and lesions

1982 • 155 citations

Profound disturbances of spontaneous and learned behaviors following lesions of the nucleus basalis magnocellularis in the rat

1985 • 154 citations

A reappraisal of the functions of the nucleus basalis of Meynert

1988 • 151 citations

Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in rats

1984 • 151 citations

Lesioning of the rat basal forebrain leads to memory impairments in passive and active avoidance tasks

1985 • 146 citations

Neurotransmitters and memory: Role of cholinergic, serotonergic, and noradrenergic systems.

1987 • 142 citations

Effect of atropine on learning, extinction, retention and retrieval in rats

1964 • 140 citations

Cholinergic projections from the basal forebrain of rat to the amygdala

1982 • 140 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 138 citations

ON THE ROLE OF “MEMORY” IN THE ANALYSIS OF BEHAVIOR

1977 • 134 citations

Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1

1986 • 132 citations

Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning

1983 • 129 citations

Some effects of scopolamine on a passive avoidance response in rats

1965 • 125 citations

Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey

1986 • 124 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 122 citations

Basal forebrain lesions and memory: Alterations in neurotensin, not acetylcholine, may cause amnesia.

1989 • 120 citations

Neurotransmitters and memory: Role of cholinergic, serotonergic, and noradrenergic systems.

1987 • 118 citations

Spatial learning in rats: Correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage

1989 • 117 citations

Pharmacological alleviation of cholinergic lesion induced memory deficits in rats

1985 • 117 citations

Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats

1984 • 116 citations

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

1988 • 115 citations

Reevaluation of the contribution of the basal forebrain cholinergic system to memory

1988 • 113 citations

The aminopyridines

1982 • 113 citations

Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance

1985 • 110 citations

Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic-acid lesions of the nucleus basalis of Meynert

1987 • 108 citations

Peptidergic neurons in the basal forebrain magnocellular complex of the rhesus monkey

1989 • 108 citations

Decrease of neocortical choline acetyltransferase after lesion of the globus pallidus in the rat

1978 • 105 citations

Basal Forebrain Cholinergic Neurons and Alzheimer’s Disease

1988 • 104 citations

Basal forebrain lesions and memory: Alterations in neurotensin, not acetylcholine, may cause amnesia.

1989 • 98 citations

Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram and behaviour.

1982 • 98 citations

Changes in high affinity choline uptake in rat cortex following lesions of the magnocellular forebrain nuclei

1982 • 96 citations

Effects of ibotenic acid lesions of the basal forebrain on serial reversal learning in marmosets

1985 • 95 citations

Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease

1986 • 94 citations

Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen

1989 • 94 citations

Effects of ganglioside treatment in rats with a lesion of the cholinergic forebrain nuclei

1985 • 93 citations

Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex

1986 • 92 citations

Effect of Unilateral Decortication on Choline Acetyltransferase Activity in the Nucleus Basalis and Other Areas of the Rat Brain

1985 • 91 citations

Effects of scopolamine on discriminated responding in the rat.

1959 • 90 citations

Nucleus basalis magnocellularis: optimal coordinates for selective reduction of choline acetyltransferase in frontal neocortex by ibotenic acid injections

1984 • 89 citations

Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex

1985 • 88 citations

Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex

1985 • 88 citations

Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats

1988 • 88 citations

Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis—I. Biochemical and anatomical observations

1985 • 85 citations

Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats

1990 • 83 citations

A long-acting cholinesterase inhibitor reverses spatial memory deficits in mice

1988 • 81 citations

Effects of concurrent manipulations of cholinergic and noradrenergic function on learning and retention in mice

1989 • 81 citations

Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents

1988 • 81 citations

Basal forebrain—lesioned monkeys are severely impaired in tasks of association and recognition memory

1987 • 80 citations

Evidence for neocortical involvement in reference memory

1987 • 79 citations

Further characterizations of the nature of the behavioral and neurochemical effects of lesions to the nucleus basalis of meynert in the rat

1985 • 77 citations

Animal studies of brain acetylcholine and memory.

1989 • 76 citations

Decreased Cortical Glucose Utilization after Ibotenate Lesion of the Rat Ventromedial Globus Pallidus

1984 • 75 citations

Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor

1986 • 75 citations

Interaction between nerve growth factor and GM1 monosialoganglioside in preventing cortical choline acetyltransferase and high affinity choline uptake decrease after lesion of the nucleus basalis

1989 • 75 citations

Unilateral and bilateral nucleus basalis lesions: Differences in neurochemical and behavioural recovery

1988 • 74 citations

Cortical cholinergic impairment and behavioral deficits produced by kainic acid lesions of rat magnocellular basal forebrain.

1985 • 74 citations

Effects of scopolamine and unilateral lesions of the basal forebrain on T-maze spatial discrimination and alternation in rats

1986 • 74 citations

Transplantation of embryonic ventral forebrain grafts to the neocortex of rats with bilateral lesions of nucleus basalis magnocellularis ameliorates a lesion-induced deficit in spatial memory

1988 • 72 citations

Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions.

1989 • 71 citations

TIME COURSE OF EFFECTS OF UNILATERAL LESIONS OF THE NUCLEUS BASALIS OF MEYNERT ON GLUCOSE UTILIZATION BY THE CEREBRAL CORTEX

1989 • 69 citations

Cortical cholinergic impairment and behavioral deficits produced by kainic acid lesions of rat magnocellular basal forebrain.

1985 • 67 citations

Effect of physostigmine on memory consolidation and retrieval processes in intact and nucleus basalis-lesioned rats

1989 • 64 citations

GM1 ganglioside facilitates the recovery of high‐affinity choline uptake in the cerebral cortex of rats with a lesion of the nucleus basalis magnocellularis

1984 • 63 citations

Functional and neurochemical cortical cholinergic impairment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat

1985 • 60 citations

Somatostatin is not co-localized in cholinergic neurons innervating the rat cerebral cortex-hippocampal formation

1982 • 60 citations

Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor

1989 • 55 citations

The cortical relationships of certain basal ganglia and the cholinergic basal forebrain nuclei

1983 • 54 citations

Continuous physostigmine infusion in rats with excitotoxic lesions of the nucleus basalis magnocellularis: effects on performance in the water maze task and cortical cholinergic markers.

1989 • 53 citations

Analysis of muscarinic receptor concentration and subtypes following lesion of rat substantia innominata

1985 • 52 citations

Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.

1988 • 50 citations

Local cerebral glucose utilization following unilateral and bilateral lesions of the nucleus basalis magnocellularis in the rat

1988 • 50 citations

Behavioral recovery following bilateral lesions of the nucleus basalis does not occur spontaneously

1986 • 48 citations

Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.

1988 • 46 citations

Nucleus basalis magnocellularis lesions: Lack of biochemical and immunocytochemical recovery and effect of cholinesterase inhibitors on passive avoidance.

1988 • 45 citations

Effects of altered cholinergic function on working and reference memory in the rat

1986 • 44 citations

Tetrahydroaminoacridine improves the spatial acquisition deficit produced by nucleus basalis lesions in rats

1990 • 44 citations

Memory related role of the posterior cholinergic system

1986 • 44 citations

Age-related recurrence of basal forebrain lesion-induced cholinergic deficits

1987 • 44 citations

Quinolinic acid neurotoxicity in the nucleus basalis antagonized by kynurenic acid

1985 • 44 citations

Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat

1989 • 44 citations

Rats with nucleus basalis magnocellularis lesions mimic mnemonic symptomatology observed in patients with dementia of the Alzheimer's type.

1987 • 44 citations

Animal Models of Alzheimer's Disease: Behavior, Pharmacology, Transplants

1986 • 44 citations

Lesions of the basal forebrain alter stimulus‐evoked metabolic activity in mouse somatosensory cortex

1989 • 43 citations

Effects of aging and cholinergic deafferentation on putative muscarinic cholinergic receptor subtypes in rat cerebral cortex

1986 • 42 citations

Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis

1984 • 42 citations

Spread of acetylcholine sensitivity in the neocortex following lesion of the nucleus basalis

1982 • 41 citations

Association of sleep parameters and memory in intact old rats and young rats with lesions in the nucleus basalis magnocellularis.

1989 • 41 citations

Basal forebrain lesions impair tactile discrimination and working memory

1989 • 39 citations

Locomotor hyperactivity in the rat after infusion of muscimol and [d-Ala2]Met-enkephalin into the nucleus basalis magnocellularis. Possible interaction with cortical cholinergic projections

1988 • 38 citations

Rats with nucleus basalis magnocellularis lesions mimic mnemonic symptomatology observed in patients with dementia of the Alzheimer's type.

1987 • 37 citations

[³H]Ketanserin (Serotonin Type 2) Binding Increases in Rat Cortex Following Basal Forebrain Lesions with Ibotenic Acid

1986 • 36 citations

Effects of nerve growth factor and GM1 ganglioside on the number and size of cholinergic neurons in rats with unilateral lesion of the nucleus basalis

1989 • 36 citations

Association of sleep parameters and memory in intact old rats and young rats with lesions in the nucleus basalis magnocellularis.

1989 • 35 citations

Effect of lesion of the nucleus basalis of rat on acetylcholine release in cerebral cortex: time course of compensatory events

1987 • 35 citations

Memory disturbances following ibotenic acid injections in the nucleus basalis magnocellularis of the rat

1988 • 35 citations

Long-term effects of cholinergic basal forebrain lesions on neuropeptide Y and somatostatin immunoreactivity in rat neocortex

1989 • 33 citations

Cortical Hypometabolism and its Recovery following Nucleus Basalis Lesions in Baboons: A PET Study

1987 • 33 citations

Lack of recovery of cortical cholinergic function following quinolinic or ibotenic acid injections into the nucleus basalis magnocellularis in rats

1986 • 33 citations

Behavioural functions of nucleus basalis magnocellularis and its relationship to dementia

1986 • 29 citations

Increased Polyphosphoinositide Responsiveness in the Cerebral Cortex Induced by Cholinergic Denervation

1988 • 26 citations

Kynurenic acid protects against the neurochemical and behavioral effects of unilateral quinolinic acid injections into the nucleus basalis of rats.

1989 • 25 citations

Nucleus basalis lesions impair memory in rats trained on nonspatial and spatial discrimination tasks

1989 • 25 citations

Persisting behavioral and neurochemical deficits in rats following lesions of the basal forebrain

1988 • 24 citations

Behavioral impairment in the rat after colchicine lesions of the hippocampus and nucleus basalis.

1988 • 24 citations

Basal forebrain and memory: Neurotoxic lesions impair serial reversals of a spatial discrimination

1988 • 23 citations

Movement and non-movement related pallidal unit activity during bar press feeding behavior in the monkey

1985 • 23 citations

Recovery of cortical acetylcholine output after ganglioside treatment in rats with lesion of the nucleus basalis

1987 • 23 citations

Lesioning of the nucleus basalis in the rat as a model of Alzheimer's disease

1986 • 23 citations

Interactions of forebrain cholinergic and somatostinergic systems in the rat

1989 • 22 citations

Age-related variations in plasticity of rat basal forebrain cholinergic neurons after cortical lesions

1988 • 22 citations

Different long-term effects of bilateral and unilateral nucleus basalis lesions on rat cerebral cortical neurotransmitter content

1989 • 22 citations

Glutamic acid decar☐ylase activity decreases in mouse neocortex after lesions of the basal forebrain

1985 • 22 citations

Nucleus basalis lesions fail to induce senile plaques in the rat

1990 • 22 citations

Effects of nBM lesions on muscarinic-stimulation of phosphoinositide hydrolysis

1989 • 20 citations

Memory retention: Effect of prolonged cholinergic stimulation in mice

1984 • 19 citations

Choline Acetyltransferase Activity in the Rat Brain Cortex Homogenate, Synaptosomes, and Capillaries After Lesioning the Nucleus Basalis Magnocellularis

1988 • 19 citations

AF64A(ethylcholine aziridinium ion)-induced basal forebrain lesion impairs maze performance

1988 • 18 citations

Kynurenic acid protects against the neurochemical and behavioral effects of unilateral quinolinic acid injections into the nucleus basalis of rats.

1989 • 18 citations

Effects of microencapsulated monosialoganglioside GM1 on cholinergic neurons

1989 • 17 citations

Maintenance of cortical somatostatin and monoamine levels in the rat does not require intact cholinergic innervation

1987 • 14 citations

Nucleus basalis magnocellularis lesions facilitate two-way active avoidance

1989 • 11 citations

Cortical muscarinic receptor function following quinolinic acid-induced lesion of the nucleus basalis magnocellularis

1989 • 11 citations

The effect of magnocellular basal forebrain lesions on circadian locomotor activity in the rat

1986 • 10 citations

Lesion of forebrain nuclei reveals possible presynaptic cholinergic muscarinic receptors in rat cerebral cortex

1983 • 8 citations

Infusion of NMDA into the nucleus basalis of Meynert, frontal cortex or lateral ventricle in rats: effect on memory and cholinergic brain neurochemistry

1989 • 8 citations

Comparative study of two types of cholinergic lesion in rats.

1989 • 5 citations

Deleted Work

1955 • 0 citations