Genes That Prolong Life: Relationships of Growth Hormone and Growth to Aging and Life Span

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Pharmacological Reviews

2024 • 2,716 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The aging process.

1981 • 1,871 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Premature mortality due to cardiovascular disease in hypopituitarism

1990 • 1,424 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*

1998 • 1,181 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Physical Activity, Obesity, and Risk for Colon Cancer and Adenoma in Men

1995 • 1,014 citations

INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS

1999 • 894 citations

Human Growth Hormone and Human Aging

1993 • 874 citations

Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study¹

1998 • 824 citations

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

1996 • 787 citations

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

1997 • 784 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

Mitotic Misregulation and Human Aging

2000 • 592 citations

Epidemiology and Long‐term Survival in Acromegaly: A Study of 166 Cases Diagnosed between 1955 and 1984

1988 • 591 citations

Effect of Growth Hormone on Carbohydrate and Lipid Metabolism

1987 • 584 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

Growth Hormone and the Heart

1994 • 526 citations

Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides

1973 • 518 citations

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human

1998 • 494 citations

Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

1993 • 477 citations

Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability

1996 • 474 citations

The maillard reaction in aging, diabetes and nutrition

1990 • 376 citations

Comparative Longevity of Pet Dogs and Humans: Implications for Gerontology Research

1997 • 333 citations

DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE

1929 • 324 citations

Human Growth Hormone

1988 • 304 citations

Height and weight in relation to breast cancer morbidity and mortality. A prospective study of 570,000 women in Norway

1989 • 280 citations

Old Age and Natural Death

2019 • 266 citations

Growth Hormone Therapy in Adults and Children

1999 • 265 citations

Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study

1998 • 259 citations

The genetics of the mouse

1952 • 254 citations

Cognitive impairments and mood disturbances in growth hormone deficient men

1996 • 205 citations

Energy metabolism and aging: a lifelong study of Fischer 344 rats

1992 • 202 citations

Insulin-Like Growth Factor-I and Cognitive Function in Healthy Older Men

1999 • 198 citations

Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency1

1998 • 178 citations

Comparative aging and life histories in mammals

1997 • 174 citations

Catalase expression in delayed and premature aging mouse models☆

2000 • 172 citations

Histology of the anterior hypophysis, thyroid and gonads of two types of dwarf mice

1964 • 171 citations

Reduced Levels of Thyroid Hormones, Insulin, and Glucose, and Lower Body Core Temperature in the Growth Hormone Receptor/Binding Protein Knockout Mouse

2001 • 167 citations

Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4

1993 • 163 citations

Pituitary and Testicular Function in Growth Hormone Receptor Gene Knockout Mice *

1999 • 157 citations

Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I

1997 • 156 citations

Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity

1984 • 153 citations

Evidence That Ames Dwarf Mice Age Differently from Their Normal Siblings in Behavioral and Learning and Memory Parameters

2001 • 152 citations

Deficits in Female Reproductive Function in GH-R-KO Mice; Role of IGF-I

1999 • 151 citations

Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice

2001 • 149 citations

Lymphocytes, Hormones and Ageing

1972 • 149 citations

Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models

1993 • 145 citations

Antioxidative Mechanisms and Plasma Growth Hormone Levels: Potential Relationship in the Aging Process

1999 • 135 citations

Kleemeier Award Lecture: Are There Genes for Aging?

1999 • 127 citations

Does growth hormone prevent or accelerate aging?

1998 • 121 citations

Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice

2000 • 118 citations

The "Little People" of the Island of Krk - Revisited. Etiology of Hypopituitarism Revealed

1999 • 118 citations

Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1

2000 • 109 citations

Induction of Endogenous Insulin-Like Growth Factor-I Secretion Alters the Hypothalamic-Pituitary-Testicular Function in Growth Hormone-Deficient Adult Dwarf Mice1

1993 • 107 citations

Low Body Temperature in Long-Lived Ames Dwarf Mice at Rest and During Stress

1999 • 106 citations

Delayed Aging in Ames Dwarf Mice. Relationships to Endocrine Function and Body Size

2000 • 106 citations

Successful selection for increased longevity in Drosophila: Analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity

1987 • 104 citations

Accelerated aging of giant transgenic mice is associated with elevated free radical processes

1996 • 103 citations

The response of two types of dwarf mice to growth hormone, thyrotropin, and thyroxine

1965 • 102 citations

Height, body mass index and mortality: Do social factors explain the association?

1992 • 101 citations

Adult height and incidence of cancer in male physicians (United States).

1997 • 100 citations

The lifetime growth and reproduction of selected strains of mice

1961 • 95 citations

Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs

1988 • 89 citations

Loss of sensitivity to insulin at early events of the insulin signaling pathway in the liver of growth hormone-transgenic mice

1999 • 87 citations

Assessment of the Primary Adrenal Cortical and Pancreatic Hormone Basal Levels in Relation to Plasma Glucose and Age in the Unstressed Ames Dwarf Mouse

1995 • 84 citations

Studies of aging in ames dwarf mice: Effects of caloric restriction

2000 • 82 citations

Dietary restriction

1995 • 78 citations

Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backross

1991 • 78 citations

Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency

1998 • 75 citations

Decrease in cellular replicative potential in “giant” mice transfected with the bovine growth hormone gene correlates to shortened life span

1993 • 73 citations

Environmental effects on longevity in the male rat: Exercise, mating, castration and restricted feeding

1976 • 72 citations

Insulin-Like Growth Factor-I and Cognitive Function in Healthy Older Men

1999 • 71 citations

Pituitary-thyroid activity and longevity in neonatally thyroxine-treated rats

1983 • 70 citations

Identification of Genes Induced by Growth Hormone in Rat Liver Using cDNA Arrays

2000 • 70 citations

Longevity and lifetime body weight in mice selected for rapid growth

1977 • 67 citations

Articular Aging and Osteoarthrosis in Dwarf Mice

1972 • 62 citations

cDNA expression arrays reveal incomplete reversal of age-related changes in gene expression by calorie restriction

2000 • 57 citations

The Molecular Genetics of Aging

2000 • 56 citations

Array-Based Expression Analysis of Mouse Liver Genes: Effect of Age and of the Longevity Mutant Prop1df

2001 • 56 citations

Expression of human FALS SOD in motorneurons of Drosophila11A. J. Elia and T. L. Parkes contributed equally to this work.

1999 • 51 citations

Height, body size and longevity.

1999 • 49 citations

Insulin-Like Growth Factor 1 Expression in Thyroid Tumors

2000 • 48 citations

Cellular Growth in the Organs of the Hypopituitary Dwarf Mouse

1968 • 47 citations

The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity☆

1999 • 43 citations

Deficits in Female Reproductive Function in GH-R-KO Mice; Role of IGF-I

1999 • 40 citations

INFLUENCE OF LUTEOTROPHIN ON FERTILITY OF DWARF MICE

1965 • 38 citations

Pituitary and Testicular Function in Growth Hormone Receptor Gene Knockout Mice

1999 • 38 citations

Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans

1997 • 33 citations

A new dwarf mouse. Abstr.

1961 • 33 citations

Untitled

2000 • 23 citations

Identification of Genes Induced by Growth Hormone in Rat Liver Using cDNA Arrays

2000 • 23 citations

Oxidative stress in hypopituitary dwarf mice and in transgenic mice overexpressing human and bovine GH

1999 • 17 citations

Height, health and growth hormone

1999 • 15 citations

Life time reproductive performance and functional changes in reproductive organs of mice selected divergently for body weight over 90 generations

1996 • 12 citations

Cell number deficiencies in the nervous system of dwarf mice

1965 • 9 citations

Stochastic studies of aging and mortality in multicellular organisms. II. The finite theory

1979 • 8 citations

Doctors and Dying

1963 • 5 citations

Height, health and growth hormone

1999 • 5 citations

Deleted Work

1955 • 0 citations