Specific inhibition of P-selectin–mediated cell adhesion by phage display–derived peptide antagonists

Rapid neutrophil adhesion to activated endothelium mediated by GMP-140

1990 • 997 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

The selecting: vascular adhesion molecules

1995 • 954 citations

Mechanisms That Regulate the Function of the Selectins and Their Ligands

1999 • 931 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1

2000 • 704 citations

The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide

1992 • 698 citations

Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment.

1997 • 620 citations

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo.

1995 • 597 citations

Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins

1996 • 534 citations

Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells.

1992 • 519 citations

Role of PSGL-1 binding to selectins in leukocyte recruitment.

1997 • 491 citations

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

2000 • 472 citations

P-selectin deficiency attenuates tumor growth and metastasis

1998 • 436 citations

A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.

1986 • 402 citations

Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.

1996 • 391 citations

Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin

1998 • 360 citations

Protective effects of oligosaccharides in P-selectin-dependent lung injury

1993 • 319 citations

Selectin ligands: will the real ones please stand up?

1997 • 307 citations

Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin

1993 • 297 citations

Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin

1998 • 296 citations

Structures of the O-Glycans on P-selectin Glycoprotein Ligand-1 from HL-60 Cells

1996 • 260 citations

Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand- 1

1995 • 258 citations

Absence of P-selectin delays fatty streak formation in mice.

1997 • 241 citations

A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin

1999 • 215 citations

P-selectin glycoprotein ligand 1 is a ligand for L-selectin on neutrophils, monocytes, and CD34+ hematopoietic progenitor cells.

1996 • 213 citations

Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment

1999 • 209 citations

Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1

1998 • 209 citations

Binding of Glycosulfopeptides to P-selectin Requires Stereospecific Contributions of Individual Tyrosine Sulfate and Sugar Residues

2000 • 204 citations

Only simultaneous blocking of the L‐ and P‐selectin completely inhibits neutrophil migration into mouse peritoneum

1994 • 201 citations

Remodeling and Neointimal Formation in the Carotid Artery of Normal and P-Selectin–Deficient Mice

1997 • 170 citations

P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is a Physiological Ligand for E-Selectin in Mediating T Helper 1 Lymphocyte Migration

2000 • 162 citations

Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear.

1993 • 149 citations

Circulating Activated Platelets Assist THP-1 Monocytoid/Endothelial Cell Interaction Under Shear Stress

1999 • 138 citations

Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactions

2001 • 133 citations

The P-Selectin Glycoprotein Ligand-1 Is Important for Recruitment of Neutrophils Into Inflamed Mouse Peritoneum

1997 • 130 citations

Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow

2001 • 126 citations

P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation

1999 • 124 citations

Identification of biologically active peptides using random libraries displayed on phage

1995 • 119 citations

Recombinant Soluble Form of PSGL-1 Accelerates Thrombolysis and Prevents Reocclusion in a Porcine Model

1999 • 114 citations

Uptake and Processing of Modified Bacteriophage M13 in Mice: Implications for Phage Display

2002 • 109 citations

Absence of P-Selectin, but Not Intercellular Adhesion Molecule-1, Attenuates Neointimal Growth After Arterial Injury in Apolipoprotein E–Deficient Mice

2001 • 105 citations

Recombinant Soluble P-Selectin Glycoprotein Ligand-1-Ig Reduces Restenosis Through Inhibition of Platelet-Neutrophil Adhesion After Double Angioplasty in Swine

2001 • 76 citations

Noncovalent Association of P-selectin Glycoprotein Ligand-1 and Minimal Determinants for Binding to P-selectin

2000 • 71 citations

Overlapping Functions of E- and P-Selectin in Neutrophil Recruitment During Acute Inflammation

1998 • 71 citations

Pharmacology of Selectin Inhibitors in Ischemia/Reperfusion States

2000 • 62 citations

Dimerization of P-Selectin Glycoprotein Ligand-1 (PSGL-1) Required for Optimal Recognition of P-Selectin

1998 • 56 citations

Soluble Monomeric P-Selectin Containing Only the Lectin and Epidermal Growth Factor Domains Binds to P-Selectin Glycoprotein Ligand-1 on Leukocytes

1997 • 51 citations

Dimerization of P-selectin in platelets and endothelial cells

2000 • 50 citations

Nanomolar E-Selectin Inhibitors: 700-Fold Potentiation of Affinity by Multivalent Ligand Presentation

2001 • 48 citations

Functions of domain 1 and 4 of vascular cell adhesion molecule-1 in alpha4 integrin-dependent adhesion under static and flow conditions are differentially regulated.

1996 • 45 citations

Dimerization of P-selectin in platelets and endothelial cells

2000 • 42 citations

Determinants in the cytoplasmic domain of P-selectin required for sorting to secretory granules

1998 • 28 citations

Expression and functional characterization of the P-selectin glycoprotein ligand-1 in various cells.

1996 • 17 citations

Soluble P-Selectin Antagonist Mediates Rolling Velocity and Adhesion of Leukocytes in Acutely Inflamed Venules

2001 • 16 citations

Soluble P-Selectin Antagonist Mediates Rolling Velocity and Adhesion of Leukocytes in Acutely Inflamed Venules

2001 • 10 citations

Anti-vWf antibodies induce GPIbalpha and FcgammaRII mediated platelet aggregation only at low shear forces.

2001 • 5 citations