Recombinant Soluble Form of PSGL-1 Accelerates Thrombolysis and Prevents Reocclusion in a Porcine Model

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

The pathogenesis of coronary artery disease and the acute coronary syndromes (First of two parts)

1992 • 1,958 citations

The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventricular Function, and Survival after Acute Myocardial Infarction

1993 • 1,861 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

1985 • 886 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

1992 • 800 citations

Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*

1987 • 751 citations

Expression cloning of a functional glycoprotein ligand for P-selectin

1993 • 734 citations

Effect of Intravenous Streptokinase on Left Ventricular Function and Early Survival after Acute Myocardial Infarction

1987 • 628 citations

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells

1989 • 538 citations

Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells.

1992 • 519 citations

GMP-140 mediates adhesion of stimulated platelets to neutrophils

1990 • 515 citations

Thrombolysis in myocardial infarction (TIMI) trial: Phase I. A comparison between intravenous tissue plasminogen activator and intravenous streptokinase

1988 • 475 citations

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

1993 • 452 citations

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

1995 • 435 citations

A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.

1986 • 402 citations

Increased Neutrophil-Platelet Adhesion in Patients With Unstable Angina

1996 • 401 citations

Rapid and sustained coronary artery recanalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation.

1988 • 394 citations

Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction?

1993 • 344 citations

Leukocyte activation with platelet adhesion after coronary angioplasty: A mechanism for recurrent disease?

1996 • 274 citations

The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.

1991 • 261 citations

A randomized trial of late reperfusion therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction-6 Study Group.

1992 • 212 citations

Remodeling and Neointimal Formation in the Carotid Artery of Normal and P-Selectin–Deficient Mice

1997 • 170 citations

Platelet-neutrophil interactions. Possible relevance in the pathogenesis of thrombosis and inflammation.

1991 • 158 citations

Neutrophil and platelet activation at balloon-injured coronary artery plaque in patients undergoing angioplasty

1996 • 152 citations

GPIIb/IIIa Antagonists: Pathophysiologic and Therapeutic Insights from Studies of c7E3 Fab

1997 • 148 citations

Specific Accumulation of Circulating Monocytes and Polymorphonuclear Leukocytes on Platelet Thrombi in a Vascular Injury Model

1997 • 119 citations

Core2 beta-1,6-N-acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin

1996 • 118 citations

Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response.

1991 • 111 citations

Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis

1997 • 111 citations

Time as an adjunctive agent to thrombolytic therapy

1994 • 104 citations

Induction of tissue factor on monocytes by adhesion to endothelial cells.

1995 • 99 citations

Neutrophil Depletion Suppresses 111In-Labeled Platelet Accumulation in Infarcted Myocardium

1985 • 95 citations

Prevention of reoccluding platelet-rich thrombi in canine femoral arteries with a novel peptide antagonist of platelet glycoprotein IIb/IIIa receptors.

1989 • 66 citations

Adjunctive Selectin Blockade Successfully Reduces Infarct Size Beyond Thrombolysis in the Electrolytic Canine Coronary Artery Model

1995 • 54 citations

Antithrombotic therapy after myocardial reperfusion in acute myocardial infarction

1988 • 51 citations

Pretreatment with a blocking monoclonal antibody to P-selectin accelerates pharmacological thrombolysis in a primate model of arterial thrombosis.

1995 • 45 citations

Abciximab (ReoPro) potentiates thrombolysis in ST elevation myocardial infarction: results of TIMI 14 trials

1998 • 35 citations

Conjunctive Use of Platelet Glycoprotein IIb/IIIa Antagonists and Thrombolytic Therapy for Acute Myocardial Infarction

1997 • 33 citations

Thrombolytic Therapy in Acute Myocardial Infarction

1996 • 28 citations

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