Hydrogen Peroxide Sensing and Signaling

Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes

2000 • 4,803 citations

Structure, mechanism and regulation of peroxiredoxins

2003 • 2,454 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Reactive oxygen species produced by NADPH oxidase regulate plant cell growth

2003 • 2,136 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

2003 • 1,317 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Tissue-specific functions of individual glutathione peroxidases

1999 • 1,115 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

The antioxidant function of the p53 tumor suppressor

2005 • 1,072 citations

Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

2002 • 1,010 citations

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

2005 • 1,003 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

A Thiol Peroxidase Is an H2O2 Receptor and Redox-Transducer in Gene Activation

2002 • 875 citations

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

2005 • 870 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3

2000 • 848 citations

Global Transcriptional Responses of Fission Yeast to Environmental Stress

2003 • 786 citations

DNA Microarray-Mediated Transcriptional Profiling of the Escherichia coli Response to Hydrogen Peroxide

2001 • 782 citations

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

2003 • 756 citations

Oxidative stress responses of the yeastSaccharomyces cerevisiae

1998 • 735 citations

Two Enzymes in One

2004 • 729 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Redox Redux: Revisiting PTPs and the Control of Cell Signaling

2005 • 696 citations

Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

1999 • 696 citations

SKN-1 linksC. elegansmesendodermal specification to a conserved oxidative stress response

2003 • 687 citations

Reactive oxygen signalling: the latest news

2004 • 687 citations

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

2003 • 627 citations

Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol—disulfide status

1999 • 561 citations

Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences

2005 • 560 citations

Structural Basis of the Redox Switch in the OxyR Transcription Factor

2001 • 544 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation

2006 • 525 citations

Nrf2, a multi‐organ protector?

2005 • 520 citations

H2O2 sensing through oxidation of the Yap1 transcription factor

2000 • 507 citations

Hydrogen peroxide as a signal controlling plant programmed cell death

2005 • 491 citations

Redox signaling in angiogenesis: Role of NADPH oxidase

2006 • 470 citations

OxyR

2002 • 459 citations

The Nox Family of NAD(P)H Oxidases: Host Defense and Beyond

2004 • 437 citations

Regulation of yAP-1 nuclear localization in response to oxidative stress

1997 • 437 citations

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

2005 • 435 citations

Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth

2005 • 434 citations

Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress

2003 • 431 citations

Reactive oxygen species as essential mediators of cell adhesion

2003 • 427 citations

The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

2005 • 400 citations

Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice

2003 • 400 citations

Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

2005 • 398 citations

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

2002 • 398 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

Proteomics Analysis of Cellular Response to Oxidative Stress

2002 • 388 citations

Localizing NADPH Oxidase–Derived ROS

2006 • 383 citations

Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria

2004 • 378 citations

Nitric oxide represses inhibitory κB kinase through S-nitrosylation

2004 • 359 citations

Regulation of SUMOylation by Reversible Oxidation of SUMO Conjugating Enzymes

2006 • 357 citations

Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems

2002 • 346 citations

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

2002 • 338 citations

Properties and Biological Activities of Thioredoxins

2001 • 317 citations

Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae

2003 • 312 citations

Yap, a Novel Family of Eight bZIP Proteins in Saccharomyces cerevisiae with Distinct Biological Functions

1997 • 302 citations

Global Analyses of Sumoylated Proteins in Saccharomyces cerevisiae

2004 • 297 citations

Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death

2005 • 293 citations

The NADPH Oxidase NOX4 Drives Cardiac Differentiation: Role in Regulating Cardiac Transcription Factors and MAP Kinase Activation

2006 • 288 citations

Regulation of inducible peroxide stress responses

2002 • 285 citations

Redox regulation of OxyR requires specific disulfide bond formation involving a rapid kinetic reaction path

2004 • 261 citations

A Conserved Stress-activated Protein Kinase Regulates a Core Stress Response in the Human PathogenCandida albicans

2004 • 253 citations

Role of reactive oxygen species and phosphatidylinositol 3‐kinase in cardiomyocyte differentiation of embryonic stem cells

2000 • 244 citations

Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means ofS-nitrosylation

2000 • 244 citations

Distinct Physiological Functions of Thiol Peroxidase Isoenzymes in Saccharomyces cerevisiae

2000 • 241 citations

Regulation of Peroxiredoxin I Activity by Cdc2-mediated Phosphorylation

2002 • 241 citations

Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation

2006 • 235 citations

A cysteine-sulfinic acid in peroxiredoxin regulates H ₂ O ₂ -sensing by the antioxidant Pap1 pathway

2005 • 235 citations

The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative

2002 • 223 citations

Sequential Activation of Phosphatidylinositol 3-Kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H₂O₂

2004 • 223 citations

Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA

2001 • 217 citations

Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells

2005 • 216 citations

Redox Regulation of Cdc25C

2002 • 213 citations

A 2-Cys Peroxiredoxin Regulates Peroxide-Induced Oxidation and Activation of a Stress-Activated MAP Kinase

2004 • 212 citations

Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells

2005 • 207 citations

Distinct Regulatory Proteins Control the Graded Transcriptional Response to Increasing H₂O₂ Levels in Fission Yeast Schizosaccharomyces pombe

2002 • 201 citations

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain

2004 • 198 citations

Two Vicinal Cysteines Confer a Peculiar Redox Regulation to Low Molecular Weight Protein Tyrosine Phosphatase in Response to Platelet-derived Growth Factor Receptor Stimulation

2001 • 190 citations

Vitamin D3-up-regulated Protein-1 Is a Stress-responsive Gene That Regulates Cardiomyocyte Viability through Interaction with Thioredoxin

2002 • 183 citations

Catalase Activity Is Regulated by c-Abl and Arg in the Oxidative Stress Response

2003 • 181 citations

Redox regulation of PTEN and protein tyrosine phosphatases in H₂O₂‐mediated cell signaling

2004 • 180 citations

Regulation of cAMP-dependent Protein Kinase Activity by Glutathionylation

2002 • 180 citations

A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress

2002 • 177 citations

Activation of ATP-sensitive K⁺(K_ATP) channels by H₂O₂underlies glutamate-dependent inhibition of striatal dopamine release

2003 • 168 citations

Peroxide Sensors for the Fission Yeast Stress-activated Mitogen-activated Protein Kinase Pathway

2001 • 168 citations

Multistep Phosphorelay Proteins Transmit Oxidative Stress Signals to the Fission Yeast Stress-activated Protein Kinase

2000 • 165 citations

Oxidation of a Eukaryotic 2-Cys Peroxiredoxin Is a Molecular Switch Controlling the Transcriptional Response to Increasing Levels of Hydrogen Peroxide

2005 • 155 citations

Ybp1 Is Required for the Hydrogen Peroxide-induced Oxidation of the Yap1 Transcription Factor

2003 • 152 citations

Hydrogen peroxide generated extracellularly by receptor–ligand interaction facilitates cell signaling

2005 • 152 citations

Global Shifts in Protein Sumoylation in Response to Electrophile and Oxidative Stress

2004 • 149 citations

OxyR: A Regulator of Antioxidant Genes

1992 • 137 citations

Dual targeting of yeast catalase A to peroxisomes and mitochondria

2004 • 135 citations

Enhanced Dephosphorylation of cAMP-dependent Protein Kinase by Oxidation and Thiol Modification

2004 • 130 citations

Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery

2006 • 129 citations

Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling

2003 • 129 citations

Glutathione Peroxidase 1 Is Regulated by the c-Abl and Arg Tyrosine Kinases

2003 • 125 citations

Partial Mitochondrial Inhibition Causes Striatal Dopamine Release Suppression and Medium Spiny Neuron Depolarization via H₂O₂Elevation, Not ATP Depletion

2005 • 112 citations

Cutting Edge: TRANK, a Novel Cytokine That Activates NF-κB and c-Jun N-Terminal Kinase

1998 • 103 citations

Catalase Is Regulated by Ubiquitination and Proteosomal Degradation. Role of the c-Abl and Arg Tyrosine Kinases

2003 • 103 citations

Regulation of Thioredoxin Peroxidase Activity by C-terminal Truncation

2002 • 103 citations

Redox regulation of the transcriptional repressor Bach1

2005 • 103 citations

Mammalian Antioxidant Defenses Are Not Inducible by H2O2

2004 • 94 citations

Thioredoxin in the cardiovascular system

2006 • 93 citations

The ASK1–MAP kinase pathways in immune and stress responses

2006 • 89 citations

Cytosolic Peroxiredoxin Attenuates The Activation Of Jnk And P38 But Potentiates That Of Erk In Hela Cells Stimulated With Tumor Necrosis Factor-α

2004 • 88 citations

The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans

2005 • 85 citations

Peroxiredoxin-Mediated Redox Regulation of the Nuclear Localization of Yap1, a Transcription Factor in Budding Yeast

2005 • 84 citations

Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants

2006 • 81 citations

SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes

2006 • 74 citations

Cross talk between Ca²⁺and redox signalling cascades in muscle and neurons through the combined activation of ryanodine receptors/Ca²⁺release channels

2005 • 67 citations

Dual Role of Peroxiredoxin I in Macrophage-derived Foam Cells

2006 • 63 citations

The Redox Domain of the Yap1p Transcription Factor Contains Two Disulfide Bonds

2003 • 59 citations

Porcine natural-killer-enhancing factor-B: oligomerisation and identification as a calpain substrate in vitro

1998 • 52 citations

Redox-Dependent Regulation of the Conformation and Function of Human Heat Shock Factor 1

2002 • 41 citations

Involvement of calcium-mediated apoptotic signals in H2O2-induced MIN6N8a cell death

2006 • 37 citations

Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling

2005 • 36 citations

Characterization of thiol‐specific antioxidant 1 (TSA1) of Candida albicans

2005 • 31 citations

Peroxiredoxin II functions as a signal terminator for H₂O₂‐activated phospholipase D1

2005 • 22 citations

Human RNase H1 Activity Is Regulated by a Unique Redox Switch Formed between Adjacent Cysteines

2003 • 21 citations

An Intramolecular Disulfide Bridge as a Catalytic Switch for Serotonin N-Acetyltransferase

2002 • 14 citations