Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis^a

2000 • 828 citations

Oxidant stress and endothelial cell dysfunction

2001 • 802 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

2000 • 661 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

1998 • 582 citations

Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients

1999 • 570 citations

Biochemical signals and biological responses elicited by the focal adhesion kinase

2001 • 568 citations

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

1998 • 496 citations

Shear stress-induced release of nitric oxide from endothelial cells grown on beads.

1991 • 488 citations

Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production

1998 • 470 citations

Reactive oxygen species as essential mediators of cell adhesion

2003 • 427 citations

Cellular oxygen sensing by mitochondria: old questions, new insight

2000 • 392 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis

1997 • 338 citations

An SH3 Domain-Containing GTPase-Activating Protein for Rho and Cdc42 Associates with Focal Adhesion Kinase

1996 • 337 citations

Mitochondrial Sources of H ₂ O ₂ Generation Play a Key Role in Flow-Mediated Dilation in Human Coronary Resistance Arteries

2003 • 317 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration

1999 • 276 citations

Cyclic Strain–Induced Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells Involves Reactive Oxygen Species Activation of Activator Protein 1

1997 • 246 citations

Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration

1999 • 224 citations

MAP Kinase Activation by Flow in Endothelial Cells

1996 • 224 citations

Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction

1999 • 220 citations

Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress

2000 • 199 citations

Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.

1996 • 188 citations

Interaction between Mitochondria and the Actin Cytoskeleton in Budding Yeast Requires Two Integral Mitochondrial Outer Membrane Proteins, Mmm1p and Mdm10p

1998 • 188 citations

Mechanical Strain on Osteoblasts Activates Autophosphorylation of Focal Adhesion Kinase and Proline-rich Tyrosine Kinase 2 Tyrosine Sites Involved in ERK Activation

2004 • 186 citations

Focal adhesion kinase promotes phospholipase C-γ1 activity

1999 • 181 citations

Adhesion at a granular surface

2000 • 169 citations

Molecular analysis of blood vessel formation and disease

1997 • 163 citations

Pulsatile Stretch Activates Mitogen-Activated Protein Kinase (MAPK) Family Members and Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes

1999 • 160 citations

Oxidative Stress-induced Phospholipase C-γ1 Activation Enhances Cell Survival

2001 • 147 citations

Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction

2004 • 147 citations

Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells

1999 • 139 citations

Inhibition of NF-κB by Pyrrolidine Dithiocarbamate Blocks Endothelial Cell Activation

1995 • 133 citations

Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells

1995 • 113 citations

Cyclic Strain–Induced Reactive Oxygen Species Involved in ICAM-1 Gene Induction in Endothelial Cells

1998 • 106 citations

Mechanical Load Enhances Procollagen Processing in Dermal Fibroblasts by Regulating Levels of Procollagen C-Proteinase

1999 • 87 citations

Sequential Activation of Protein Kinase C (PKC)-α and PKC-ε Contributes to Sustained Raf/ERK1/2 Activation in Endothelial Cells under Mechanical Strain

2001 • 80 citations

Focal Adhesion Kinase Regulation by Oxidative Stress in Different Cell Types

2000 • 79 citations

Focal Adhesion Kinase Regulation by Oxidative Stress in Different Cell Types

2000 • 65 citations

Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro.

1992 • 54 citations

Role of Protein Kinase C in Basal and Hydrogen Peroxide-Stimulated NF-κB Activation in the Murine Macrophage J774A.1 Cell Line

1998 • 53 citations

Differential regulation of inositol 1,4,5‐trisphosphate by co‐existing P_2Y‐purinoceptors and nucleotide receptors on bovine aortic endothelial cells

1994 • 48 citations

Hypoxia and Stretch Regulate Intercellular Communication in Vascular Smooth Muscle Cells Through Reactive Oxygen Species Formation

2003 • 41 citations

Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts

1994 • 40 citations

The pathway of electron flow through ubiquinol:cytochrome c oxidoreductase in the respiratory chain. Evidence from inhibition studies for a modified ‘Q cycle’

1982 • 18 citations