Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

2003 • 2,104 citations

Atmospheric carbon dioxide concentrations over the past 60 million years

2000 • 1,734 citations

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

2002 • 1,497 citations

Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis

2004 • 1,245 citations

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

Epigenetic Codes for Heterochromatin Formation and Silencing

2002 • 858 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development

2003 • 797 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals

1998 • 591 citations

HP1 and the dynamics of heterochromatin maintenance

2004 • 576 citations

The RCAF complex mediates chromatin assembly during DNA replication and repair

1999 • 539 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.

1994 • 492 citations

The function of PML in p53-dependent apoptosis

2000 • 464 citations

Identification of High-Copy Disruptors of Telomeric Silencing in Saccharomyces cerevisiae

1998 • 452 citations

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

1992 • 441 citations

HIRA Is Critical for a Nucleosome Assembly Pathway Independent of DNA Synthesis

2002 • 406 citations

Regulation of p53 activity in nuclear bodies by a specific PML isoform

2000 • 371 citations

Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors

1996 • 368 citations

Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies

2002 • 308 citations

PML Is a Direct p53 Target that Modulates p53 Effector Functions

2004 • 298 citations

Form follows function: the genomic organization of cellular differentiation

2004 • 297 citations

Chromatin Disassembly Mediated by the Histone Chaperone Asf1 Is Essential for Transcriptional Activation of the Yeast PHO5 and PHO8 Genes

2004 • 293 citations

Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

1998 • 269 citations

The Histone Variant MacroH2A Interferes with Transcription Factor Binding and SWI/SNF Nucleosome Remodeling

2003 • 267 citations

Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest

2003 • 260 citations

Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing

2001 • 259 citations

Two New S-Phase-Specific Genes fromSaccharomyces cerevisiae

1997 • 213 citations

In vivo kinetics of Cajal body components

2004 • 212 citations

Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture

2002 • 179 citations

Coupling of DNA Synthesis and Histone Synthesis in S Phase Independent of Cyclin/cdk2 Activity

2002 • 173 citations

Chromatin Assembly Factor I Mutants Defective for PCNA Binding Require Asf1/Hir Proteins for Silencing

2002 • 169 citations

Hir Proteins Are Required for Position-Dependent Gene Silencing in Saccharomyces cerevisiae in the Absence of Chromatin Assembly Factor I

1998 • 167 citations

MACROH2A2, a New Member of the MACROH2A Core Histone Family

2001 • 154 citations

Yeast ASF1 Protein Is Required for Cell Cycle Regulation of Histone Gene Transcription

2001 • 150 citations

Role of PML and PML-RARα in Mad-Mediated Transcriptional Repression

2001 • 143 citations

Structure and Function of the Conserved Core of Histone Deposition Protein Asf1

2003 • 143 citations

Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae

2002 • 136 citations

Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

2002 • 134 citations

Hir1p and Hir2p Function as Transcriptional Corepressors To Regulate Histone Gene Transcription in the Saccharomyces cerevisiae Cell Cycle

1997 • 134 citations

HIRA, the Human Homologue of Yeast Hir1p and Hir2p, Is a Novel Cyclin-cdk2 Substrate Whose Expression Blocks S-Phase Progression

2001 • 123 citations

A dynamic connection between centromeres and ND10 proteins

1999 • 107 citations

Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery

2002 • 107 citations

Replicative senescence: Considerations relating to the stability of heterochromatin domains

1996 • 74 citations

Isolation and characterization of a new gene encoding a member of the HIRA family of proteins from Drosophila melanogaster

1998 • 38 citations

Stimulation of WI‐38 cell cycle transit: Effect of serum concentration and cell density

1976 • 19 citations