Hir1p and Hir2p Function as Transcriptional Corepressors To Regulate Histone Gene Transcription in the Saccharomyces cerevisiae Cell Cycle

Methods in yeast genetics

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Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

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1988 • 4,905 citations

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1988 • 4,543 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Transcriptional regulation

1991 • 893 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

Ssn6-Tup1 is a general repressor of transcription in yeast

1992 • 680 citations

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

1994 • 547 citations

THE REGULATION OF HISTONE SYNTHESIS IN THE CELL CYCLE

1991 • 498 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein.

1995 • 394 citations

Cell cycle control of the yeast HO gene: Cis- and Trans-acting regulators

1987 • 392 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast

1991 • 354 citations

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

1990 • 350 citations

Functional dissection of the yeast Cyc8–Tupl transcriptional co-repressor complex

1994 • 338 citations

Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription

1991 • 313 citations

Sequential function of gene products relative to DNA synthesis in the yeast cell cycle

1976 • 302 citations

Cell cycle regulted transcription in yeast

1994 • 283 citations

Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.

1995 • 258 citations

A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene

1984 • 237 citations

Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast

1994 • 227 citations

The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex.

1991 • 216 citations

The WD repeats of Tup1 interact with the homeo domain protein alpha 2.

1994 • 207 citations

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

1993 • 207 citations

Identification of sequences in a yeast histone promoter involved in periodic transcription

1986 • 207 citations

The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure.

1994 • 190 citations

SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.

1991 • 179 citations

SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.

1992 • 176 citations

Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene

1989 • 171 citations

SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast

1992 • 169 citations

Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2.

1996 • 164 citations

Periodic transcription of yeast histone genes

1982 • 160 citations

Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae.

1993 • 146 citations

The SPT6 gene is essential for growth and is required for delta-mediated transcription in Saccharomyces cerevisiae.

1987 • 132 citations

Trans-acting regulatory mutations that alter transcription of Saccharomyces cerevisiae histone genes.

1987 • 126 citations

A human homolog of the S.cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region

1995 • 121 citations

Transcriptional repression directed by the yeast α2 protein in vitro

1994 • 118 citations

Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae.

1993 • 107 citations

The CDC8 transcript is cell cycle regulated in yeast and is expressed coordinately with CDC9 and CDC21 at a point preceding histone transcription

1987 • 103 citations

Start-Specific Transcription in Yeast

1996 • 88 citations

Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae.

1992 • 84 citations

Role of transcriptional and posttranscriptional regulation in expression of histone genes in Saccharomyces cerevisiae.

1987 • 75 citations

Molecular and genetic characterization of SPT4, a gene important for transcription initiation in Saccharomyces cerevisiae

1993 • 61 citations

The Effect of Histone Gene Deletions on Chromatin Structure in Saccharomyces cerevisiae

1988 • 61 citations

A yeast H2A-H2B promoter can be regulated by changes in histone gene copy number.

1990 • 57 citations

Histone regulatory (hir) mutations suppress delta insertion alleles in Saccharomyces cerevisiae.

1991 • 49 citations

Functional Analysis of Histones H2A and H2B in Transcriptional Repression in Saccharomyces cerevisiae

1996 • 41 citations

Histone H3 Transcription in Saccharomyces cerevisiae Is Controlled by Multiple Cell Cycle Activation Sites and a Constitutive Negative Regulatory Element

1992 • 39 citations

Three independent forms of regulation affect expression of HO, CLN1 and CLN2 during the cell cycle of Saccharomyces cerevisiae.

1994 • 23 citations

The HIR4-1 mutation defines a new class of histone regulatory genes in Saccharomyces cerevisiae.

1993 • 18 citations

38 Mechanism and Regulation of Transcriptional Activation in Eukaryotes: Conserved Features from Yeasts to Humans

1992 • 10 citations