Protein Kinase C Phosphorylated at a Conserved Threonine Is Retained in the Cytoplasm

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

1995 • 472 citations

Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.

1993 • 439 citations

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

1998 • 383 citations

Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation

1998 • 333 citations

Mechanism of protein kinase C activation during the induction and maintenance of long-term potentiation probed using a selective peptide substrate.

1993 • 243 citations

Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

1997 • 194 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Cα

1996 • 175 citations

Persistent protein kinase activation in the maintenance phase of long-term potentiation.

1991 • 166 citations

Ubiquitination of Protein Kinase C-α and Degradation by the Proteasome

1996 • 161 citations

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

1994 • 159 citations

Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region.

1992 • 157 citations

Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C

1997 • 151 citations

Autophosphorylation of Protein Kinase C at Three Separated Regions of Its Primary Sequence

1990 • 151 citations

Induction of a Specific Olfactory Memory Leads to a Long-Lasting Activation of Protein Kinase C in the Antennal Lobe of the Honeybee

1998 • 131 citations

Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII

1999 • 130 citations

High Cooperativity, Specificity, and Multiplicity in the Protein Kinase C-Lipid Interaction

1989 • 116 citations

Determination of in Vivo Phosphorylation Sites in Protein Kinase C

1995 • 102 citations

Cloning and characterization of Ca(2+)-dependent and Ca(2+)-independent PKCs expressed in Aplysia sensory cells

1991 • 88 citations

Persistent activation of protein kinase C during the development of long-term facilitation in Aplysia.

1994 • 79 citations

An Essential Role for Autophosphorylation in the Dissociation of Activated Protein Kinase C from the Plasma Membrane

1998 • 77 citations

Characterization of two isoforms of protein kinase C in the nervous system of Aplysia californica.

1993 • 66 citations

Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors.

1991 • 63 citations

Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation

1998 • 57 citations

Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation.

1994 • 56 citations

Binding of Protein Kinase C Isoforms to Actin in Aplysia

1998 • 46 citations

Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.

1993 • 33 citations

Expression and characterization of Aplysia protein kinase C: a negative regulatory role for the E region

1996 • 29 citations

Cloning and Characterization of Aplycalcin and Aplysia Neurocalcin, Two New Members of the Calmodulin Superfamily of Small Calcium-Binding Proteins

1996 • 27 citations

The Role of C2 Domains in Ca2+-activated and Ca2+-independent Protein Kinase Cs in Aplysia

1998 • 27 citations

An autonomous kinase generated during long-term facilitation in Aplysia is related to the Ca(2+)-independent protein kinase C Apl II.

1997 • 24 citations

Translocation of protein kinase Cs in Aplysia neurons: evidence for complex regulation

1994 • 15 citations

Unique Phosphorylation of Protein Kinase C-α in PC12 Cells Induces Resistance to Translocation and Down-regulation

1996 • 13 citations