Expression and characterization of Aplysia protein kinase C: a negative regulatory role for the E region

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.

1987 • 1,703 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Lipid activation of protein kinase C.

1991 • 566 citations

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

1990 • 434 citations

Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in aplysia sensory neurons

1992 • 253 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

Isolation and characterization of delta-subspecies of protein kinase C from rat brain.

1992 • 218 citations

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.

1986 • 217 citations

Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 183 citations

Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons.

1990 • 173 citations

Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain.

1992 • 140 citations

Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C

1989 • 138 citations

Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.

1990 • 126 citations

Agonists and antagonists of protein kinase C function, derived from its binding proteins.

1994 • 125 citations

Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition.

1990 • 116 citations

Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia

1992 • 112 citations

Distinct mechanisms of regulation of protein kinase C epsilon by hormones and phorbol diesters.

1991 • 107 citations

Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons.

1990 • 102 citations

Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells.

1994 • 93 citations

Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.

1991 • 89 citations

Cloning and characterization of Ca(2+)-dependent and Ca(2+)-independent PKCs expressed in Aplysia sensory cells

1991 • 88 citations

The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.

1994 • 84 citations

Cognitive kinases.

1993 • 82 citations

Persistent activation of protein kinase C during the development of long-term facilitation in Aplysia.

1994 • 79 citations

The contributions of protein kinase A and protein kinase C to the actions of 5-HT on the L-type Ca2+ current of the sensory neurons in Aplysia

1993 • 79 citations

Calcium-dependent activation of protein kinase C. The role of the C2 domain in divalent cation selectivity.

1993 • 78 citations

A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.

1994 • 77 citations

Imaging terminals of Aplysia sensory neurons demonstrates role of enhanced Ca2+ influx in presynaptic facilitation

1993 • 74 citations

Selective activation of Ca(2+)-activated PKCs in Aplysia neurons by 5- HT

1992 • 72 citations

Ca2+-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence

1993 • 68 citations

Characterization of two isoforms of protein kinase C in the nervous system of Aplysia californica.

1993 • 66 citations

Structure and expression of a novel, neuronal protein kinase C (PKC1B) from Caenorhabditis elegans. PKC1B is expressed selectively in neurons that receive, transmit, and process environmental signals.

1994 • 59 citations

Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma cell line.

1992 • 59 citations

Expression of a functional protein kinase C-γ using a baculovirus vector: Purification and characterisation of a single protein kinase C iso-enzyme

1989 • 47 citations

A role for protein kinase C in associative learning.

1991 • 41 citations

Activators of protein kinase C mimic serotonin-induced modulation of a voltage-dependent potassium current in pleural sensory neurons of Aplysia

1994 • 38 citations

Altered substrate selectivity of PKC‐η pseudosubstrate site mutants

1993 • 26 citations

Translocation of protein kinase Cs in Aplysia neurons: evidence for complex regulation

1994 • 15 citations

Mixed micellar assay for phorbol ester binding

1987 • 14 citations