Drosophila Smad2 Opposes Mad Signaling during Wing Vein Development

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

2007 • 2,649 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

2002 • 1,088 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

2009 • 665 citations

Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

2003 • 657 citations

Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal

2007 • 536 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

2009 • 466 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

2007 • 414 citations

Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs

2000 • 402 citations

The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

1998 • 390 citations

The Decapentaplegic morphogen gradient: from pattern formation to growth regulation

2007 • 377 citations

Making a better RNAi vector for Drosophila: use of intron spacers

2003 • 367 citations

The wingless signalling pathway and the patterning of the wing margin in Drosophila

1994 • 354 citations

TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads

1999 • 324 citations

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

1996 • 275 citations

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

1997 • 260 citations

Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

2008 • 257 citations

Wing Vein Patterning in Drosophila and the Analysis of Intercellular Signaling

2007 • 249 citations

Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field

2005 • 247 citations

TGF-β Signaling Activates Steroid Hormone Receptor Expression during Neuronal Remodeling in the Drosophila Brain

2003 • 230 citations

Mads and Smads in TGFβ signalling

1998 • 194 citations

Pattern formation in the Drosophila wing: The development of the veins

2003 • 194 citations

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

1999 • 190 citations

Spemann’s organizer and the self-regulation of embryonic fields

2009 • 189 citations

A characterization of the effects of Dpp signaling on cell growth and proliferation in theDrosophilawing

2002 • 180 citations

Asymmetric mitosis: Unequal segregation of proteins destined for degradation

2008 • 168 citations

Transcriptional regulation of BMP4 synexpression in transgenic Xenopus

2004 • 160 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4

1998 • 113 citations

The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling

1998 • 112 citations

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity

2000 • 103 citations

Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo

2009 • 93 citations

Cloning and expression analysis of a novel mouse gene with sequence similarity to the Drosophila fat facets gene

1997 • 87 citations

The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning

2007 • 83 citations

Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone

2005 • 81 citations

Integrating positional information at the level of Smad1/5/8

2008 • 80 citations

Drosophila Activin-β and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain

2008 • 78 citations

Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad

2009 • 63 citations

Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development

2005 • 63 citations

Cancer-Associated Transforming Growth Factor β Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype

2008 • 61 citations

Baboon/dSmad2 TGF-β signaling is required during late larval stage for development of adult-specific neurons

2006 • 57 citations

Mad Is Required for Wingless Signaling in Wing Development and Segment Patterning in Drosophila

2009 • 49 citations

PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1

2009 • 48 citations

The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon

2009 • 44 citations

shaggy (zeste-white 3) and the formation of supernumerary bristle precursors in the developing wing blade of Drosophila

1992 • 40 citations

DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes inDrosophila

2005 • 29 citations

Identification of a NovelDrosophilaSMAD on the X Chromosome

1998 • 28 citations

Regulation of decapentaplegic expression during Drosophila wing veins pupal development

2006 • 28 citations

Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation

2009 • 27 citations

The cellular and genetic bases of organ size and shape in Drosophila

2009 • 26 citations

Identification of Chromosomal Regions Involved in decapentaplegic Function in Drosophila

1998 • 15 citations

Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-β family members

2007 • 14 citations