Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

2007 • 2,826 citations

Smad transcription factors

2005 • 2,366 citations

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

2007 • 2,210 citations

BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

2003 • 2,079 citations

A small molecule–kinase interaction map for clinical kinase inhibitors

2005 • 1,854 citations

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

2005 • 1,734 citations

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

2003 • 1,497 citations

For the Long Run

2004 • 1,289 citations

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

2000 • 1,049 citations

hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts

2003 • 1,028 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

In vitro differentiation of embryonic stem cells

1995 • 965 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon

2006 • 849 citations

Phosphorylation and functions of the RNA polymerase II CTD

2006 • 724 citations

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

2008 • 634 citations

Hippo signaling in organ size control

2007 • 622 citations

Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover

2004 • 595 citations

Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal

2007 • 536 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells

1999 • 514 citations

The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

2004 • 504 citations

Cyclin-dependent kinases regulate the antiproliferative function of Smads

2004 • 485 citations

PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

2006 • 466 citations

Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development

2002 • 432 citations

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

2008 • 426 citations

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

2007 • 414 citations

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

2003 • 411 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

Dynamic regulation of pol II transcription by the mammalian Mediator complex

2005 • 382 citations

The Decapentaplegic morphogen gradient: from pattern formation to growth regulation

2007 • 377 citations

YAP regulates neural progenitor cell number via the TEA domain transcription factor

2008 • 370 citations

Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

2000 • 367 citations

Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ Pathway

2006 • 365 citations

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R‐roscovitine)

2002 • 365 citations

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

2009 • 347 citations

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

1997 • 344 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

From Cell Structure to Transcription: Hippo Forges a New Path

2006 • 337 citations

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

2001 • 308 citations

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

2008 • 280 citations

Smad2 Nucleocytoplasmic Shuttling by Nucleoporins CAN/Nup214 and Nup153 Feeds TGFβ Signaling Complexes in the Cytoplasm and Nucleus

2002 • 252 citations

CDK8 Is a Stimulus-Specific Positive Coregulator of p53 Target Genes

2007 • 246 citations

A FoxO–Smad synexpression group in human keratinocytes

2006 • 237 citations

The multi-tasking P-TEFb complex

2008 • 225 citations

The disparate role of BMP in stem cell biology

2005 • 197 citations

Preclinical and Clinical Development of the Cyclin-Dependent Kinase Inhibitor Flavopiridol

2004 • 192 citations

Genes Affecting Cell Competition in Drosophila

2006 • 186 citations

A characterization of the effects of Dpp signaling on cell growth and proliferation in theDrosophilawing

2002 • 180 citations

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis

2004 • 162 citations

Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

2006 • 125 citations

Genome-wide Impact of the BRG1 SWI/SNF Chromatin Remodeler on the Transforming Growth Factor β Transcriptional Program

2007 • 115 citations

Nucleocytoplasmic Shuttling of Smad1 Conferred by Its Nuclear Localization and Nuclear Export Signals

2001 • 114 citations

Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

2002 • 106 citations

The Carboxyl-Terminal Domain of RNA Polymerase II Is Phosphorylated by a Complex Containing cdk9 and Infected-Cell Protein 22 of Herpes Simplex Virus 1

2005 • 69 citations

Different Sensitivity of the Transforming Growth Factor-β Cell Cycle Arrest Pathway to c-Myc and MDM-2

2000 • 25 citations

In vitro sensitivity of T-cell lymphoblastic leukemia to UCN-01 (7-hydroxystaurosporine) is dependent on p16 protein status: a Pediatric Oncology Group study.

2000 • 12 citations