Addressing the mysteries of perforin function

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

1999 • 1,212 citations

Functional significance of the perforin/granzyme cell death pathway

2002 • 1,186 citations

Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

2003 • 905 citations

Cytotoxic T lymphocytes: all roads lead to death

2002 • 893 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

2000 • 540 citations

Familial Haemophagocytic Reticulosis

1952 • 539 citations

Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis

2001 • 529 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Incidence in Sweden and Clinical Features of Familial Hemophagocytic Lymphohistiocytosis

1991 • 432 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

2002 • 363 citations

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes.

1985 • 300 citations

Perforin Is a Major Contributor to NK Cell Control of Tumor Metastasis

1999 • 290 citations

Spectrum of Perforin Gene Mutations in Familial Hemophagocytic Lymphohistiocytosis

2001 • 253 citations

Granzyme B: pro-apoptotic, antiviral and antitumor functions

2003 • 247 citations

Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and γδ T Cells

2004 • 246 citations

Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members

2002 • 244 citations

Electrostatic Control of the Membrane Targeting of C2 Domains

2002 • 222 citations

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain

1997 • 195 citations

A proportion of patients with lymphoma may harbor mutations of the perforin gene

2005 • 182 citations

Different roles for rcytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses

1996 • 171 citations

Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

1999 • 151 citations

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

2002 • 145 citations

Calcium-dependent Plasma Membrane Binding and Cell Lysis by Perforin Are Mediated through Its C2 Domain

2004 • 145 citations

Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions

2005 • 135 citations

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis

2005 • 111 citations

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

1991 • 104 citations

Ca2+ Signaling Modulates Cytolytic T Lymphocyte Effector Functions

1998 • 90 citations

Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells.

1986 • 84 citations

Familial Haemophagocytic Reticulosis

1958 • 82 citations

Perforin defects of primary haemophagocytic lymphohistiocytosis in Japan

2002 • 77 citations

Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences

2004 • 75 citations

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene

2004 • 72 citations

Dual Mechanisms of Apoptosis Induction by Cytotoxic Lymphocytes

1998 • 72 citations

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore‐forming protein, perforin, and the serine protease, granzyme B

1995 • 63 citations

A pore-forming protein, perforin, from a non-mammalian organism, Japanese flounder, Paralichthys olivaceus

2004 • 58 citations

Atypical features of familial hemophagocytic lymphohistiocytosis

2004 • 56 citations

Mapping Low Molecular Weight Plasma Proteome of Chronic Lymphoblastic Leukemia Patients Using MALDI-TOF Mass Spectrometry.

2004 • 5 citations

Deleted Work

1955 • 0 citations