Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

1999 • 1,212 citations

HLH-94: A treatment protocol for hemophagocytic lymphohistiocytosis

1997 • 504 citations

CD8+ T-cell selection, function, and death in the primary immune response in vivo

2000 • 159 citations

Defective Natural Killer Cell Function in Patients with Hemophagocytic Lymphohistiocytosis and in First Degree Relatives

1998 • 137 citations

Age-Related Decline of Perforin Expression in Human Cytotoxic T Lymphocytes and Natural Killer Cells

1998 • 129 citations

Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.

1990 • 106 citations

Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo.

1990 • 100 citations

Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

1990 • 93 citations

Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes

1995 • 88 citations

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

1987 • 86 citations

Familial erythrophagocytic lymphohistiocytosis.

1991 • 51 citations

Cytotoxic activity against tumour cells mediated by intermediate TCR cells in the liver and spleen

1996 • 47 citations

Expansion of CD56+ NK T and γδ T cells from cord blood of human neonates

1998 • 46 citations

Genetic analysis of familial erythrophagocytic lymphohistiocytosis

1984 • 44 citations

Nuclear translocation of granzyme B in target cell apoptosis

2000 • 35 citations

The role of cisplatin in treatment regimens for squamous cell carcinoma of the head and neck.

1991 • 29 citations

Flow cytometric detection of perforin in normal human lymphocyte subpopulations defined by expression of activation/differentiation antigens

1998 • 28 citations

Phenotypical and functional analyses of natural killer cells from low NK activity individuals among healthy and patient populations.

1995 • 16 citations

Flow Cytometric Analysis on Perforin Induction in Peripheral Blood Mononuclear Cells with Interleukin-2 or OK-432

1992 • 11 citations

Deleted Work

1955 • 0 citations