Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Wnt genes

1992 • 799 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.

1993 • 616 citations

Signal transduction by the Wnt family of ligands

1998 • 474 citations

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

1999 • 409 citations

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1996 • 396 citations

A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled

1996 • 369 citations

Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin

1998 • 366 citations

Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

1999 • 365 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

1998 • 302 citations

Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

1994 • 292 citations

Dishevelled Proteins Lead to Two Signaling Pathways

1999 • 291 citations

Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription

1999 • 251 citations

Signaling by wingless in Drosophila

1994 • 200 citations

The genetic basis of patterned baldness in Drosophila

1994 • 182 citations

Isolation and Characterization of a Mouse Homolog of the Drosophila Segment Polarity Gene dishevelled

1994 • 182 citations

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas

1997 • 130 citations

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

1996 • 110 citations

Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.

1992 • 103 citations

Isolation and characterization of mouseDishevelled-3

1996 • 101 citations

The role of Wnt genes in vertebrate development

1992 • 64 citations

Regulation of Ribosomal S6 Protein Kinase-p90^rsk, Glycogen Synthase Kinase 3, and β-Catenin in Early Xenopus Development

1999 • 60 citations

Signalling via phosphoinositide 30H kinases

1997 • 33 citations