Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

2003 • 1,157 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

DNA end-joining: from yeast to man

1998 • 586 citations

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

1998 • 581 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Repair of DNA double strand breaks by non-homologous end joining

2003 • 366 citations

5 DNA Breakage and Repair

1998 • 363 citations

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

1998 • 361 citations

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

1996 • 349 citations

Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

2003 • 317 citations

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

1999 • 295 citations

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

2004 • 262 citations

Genomic integrity and the repair of double-strand DNA breaks

2001 • 247 citations

Double-strand breaks and tumorigenesis

2001 • 243 citations

The DNA‐dependent protein kinase: the director at the end

2004 • 209 citations

Recent Advances in Understanding V(D)J Recombination

1997 • 196 citations

DNA-dependent protein kinase

1997 • 181 citations

Interactive competition between homologous recombination and non-homologous end joining.

2003 • 173 citations

A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation.

1997 • 165 citations

Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts.

1985 • 143 citations

Non-homologous End Joining Requires That the DNA-PK Complex Undergo an Autophosphorylation-dependent Rearrangement at DNA Ends

2004 • 138 citations

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

2004 • 138 citations

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

2004 • 135 citations

Backup pathways of NHEJ are suppressed by DNA‐PK

2004 • 128 citations

The role of DNA dependent protein kinase in synapsis of DNA ends

2003 • 122 citations

The mammalian XRCC genes: their roles in DNA repair and genetic stability

2003 • 118 citations

The DNA-Activated Protein Kinase — DNA-PK

1996 • 111 citations

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

2000 • 102 citations

DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues

1999 • 94 citations

Repair of DNA Covalently Linked to Protein

2004 • 83 citations

The kinase activity of DNA-PK is required to protect mammalian telomeres

2003 • 82 citations

Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK

2000 • 79 citations

Raf-1 is required for T cell IL2 production.

1993 • 78 citations

Differential etoposide sensitivity of cells deficient in the Ku and DNA- PKcs components of the DNA-dependent protein kinase

1998 • 62 citations

Distinct Pathways of Nonhomologous End Joining That Are Differentially Regulated by DNA-dependent Protein Kinase-mediated Phosphorylation

2003 • 61 citations

Severe combined immunodeficient cells expressing mutant hRAD54 exhibit a marked DNA double-strand break repair and error-prone chromosome repair defect.

2001 • 28 citations

Analyses of TCRB Rearrangements Substantiate a Profound Deficit in Recombination Signal Sequence Joining in SCID Foals: Implications for the Role of DNA-Dependent Protein Kinase in V(D)J Recombination

2000 • 27 citations

The isolation and genetic analysis of V79-derived etoposide sensitive Chinese hamster cell mutants: two new complementation groups of etoposide sensitive mutants

1999 • 25 citations

Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs

1996 • 17 citations

The MurineDNA-PKcsGene Consists of 86 Exons Dispersed in More Than 250 kb

1997 • 16 citations

Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions

2004 • 9 citations

Evolving "faces" of the next generations of pediatric patients.

1997 • 4 citations