Double-strand breaks and tumorigenesis

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1999 • 1,322 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

2001 • 1,206 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Chromosomal stability and the DNA double-stranded break connection

2001 • 1,180 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

The importance of repairing stalled replication forks

2000 • 1,054 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

2001 • 893 citations

The Genetic Basis of Human Cancer

1999 • 827 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

2001 • 691 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

2000 • 575 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

Involvement of Brca1 in S-Phase and G₂-Phase Checkpoints after Ionizing Irradiation

2001 • 537 citations

Chromosome Instability and Defective Recombinational Repair in Knockout Mutants of the Five Rad51 Paralogs

2001 • 519 citations

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

2000 • 491 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

1997 • 438 citations

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

1999 • 406 citations

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

2001 • 392 citations

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

2001 • 379 citations

5 DNA Breakage and Repair

1998 • 363 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

Insights into the functions of BRCA1 and BRCA2

2000 • 335 citations

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

1999 • 327 citations

Genetic polymorphisms in DNA repair genes and risk of lung cancer

2001 • 323 citations

Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

1998 • 317 citations

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

2000 • 315 citations

A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.

2000 • 306 citations

DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study

2001 • 299 citations

Direct DNA binding by Brca1

2001 • 277 citations

Double-strand-break-induced homologous recombination in mammalian cells

2001 • 260 citations

Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

2000 • 247 citations

Double-strand-break-induced homologous recombination in mammalian cells

2001 • 235 citations

The Mre11 complex and ATM: collaborating to navigate S phase

2000 • 234 citations

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

2001 • 227 citations

Recombinational DNA Repair in Bacteria and the RecA Protein

1999 • 213 citations

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

2000 • 194 citations

A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers

2001 • 189 citations

Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group

2001 • 174 citations

Mouse RAD54 Affects DNA Double-Strand Break Repair and Sister Chromatid Exchange

2000 • 170 citations

Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53^−/− Background

1999 • 166 citations

Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53

2000 • 159 citations

Midgestation lethality in mice deficient for the RecA-related gene,Rad51d/Rad51l3

2000 • 154 citations

A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.

2001 • 152 citations

Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas.

1999 • 142 citations

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer

1999 • 135 citations

The contribution of homologous recombination in preserving genome integrity in mammalian cells

1999 • 132 citations

Tumorigenesis in mice carrying a truncating Brca1 mutation

2001 • 129 citations

Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene.

2001 • 128 citations

Cellular and Biochemical Impact of a Mutation in DNA Ligase IV Conferring Clinical Radiosensitivity

2001 • 125 citations

Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

2001 • 107 citations

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

2001 • 104 citations

Identification of Rad51 alteration in patients with bilateral breast cancer

2000 • 103 citations

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

1999 • 96 citations

Breast Carcinomas Arising in Carriers of Mutations in BRCA1 or BRCA2: Are They Prognostically Different?

1999 • 95 citations

Mutations in the RAD54 recombination gene in primary cancers

1999 • 77 citations

Brca1 required for T cell lineage development but not TCR loci rearrangement

2000 • 72 citations

Genetic Disorders Associated with Cancer Predisposition and Genomic Instability

1999 • 71 citations

A Novel Human Rad54 Homologue, Rad54B, Associates with Rad51

2000 • 66 citations

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

2001 • 58 citations

Common nonsense mutations in RAD52.

1999 • 34 citations

Apparent human BRCA1 knockout caused by mispriming during polymerase chain reaction: Implications for genetic testing

2001 • 27 citations

Double-Strand Break Repair and Homologous Recombination in Mammalian Cells

2001 • 10 citations