Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Reversal of human cellular senescence: roles of the p53 and p16 pathways

2003 • 1,342 citations

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2004 • 1,246 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Protection of mammalian telomeres

2002 • 926 citations

The p16INK4a/CDKN2A tumor suppressor and its relatives

1998 • 917 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Telomerase Maintains Telomere Structure in Normal Human Cells

2003 • 738 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

Raf proteins and cancer: B-Raf is identified as a mutational target

2003 • 454 citations

Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

2002 • 425 citations

Beginning to Understand the End of the Chromosome

2004 • 416 citations

Adult human mesenchymal stem cell as a target for neoplastic transformation

2004 • 345 citations

Activation of telomerase in a human tumor.

1994 • 289 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

Tumor suppressor genes in normal and malignant hematopoiesis

2002 • 237 citations

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

2004 • 219 citations

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

2002 • 211 citations

Telomerase is not an oncogene

2002 • 193 citations

The tumor-suppressive functions of the human INK4A locus

2003 • 192 citations

p53 gene mutations in human epithelial skin cancers.

1993 • 179 citations

Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.

2003 • 147 citations

The good, the bad and the ugly: the practical consequences of centrosome amplification

2003 • 137 citations

Risky immortalization by telomerase

2000 • 132 citations

Involvement of the INK4a/Arf gene locus in senescence

2003 • 109 citations

Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

2003 • 97 citations

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

2003 • 94 citations

Ras redux: rethinking how and where Ras acts

2003 • 91 citations

Molecular and Cell Biology of Replicative Senescence

1994 • 86 citations

Alterations and hypermethylation of thep14ARF gene in gastric cancer

2000 • 86 citations

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

2003 • 82 citations

Association of p16INK4a and pRb inactivation with immortalization of human cells

2002 • 56 citations

Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma.

2004 • 55 citations

Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts

2004 • 51 citations

Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals

2003 • 49 citations

Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization

2004 • 37 citations

Understanding transformation: progress and gaps

2004 • 32 citations

Cell Immortality and Hallmarks of Cancer

2003 • 25 citations

The Significance of p16INK4a in Cell Defences Against Transformation

2004 • 15 citations

Occurrence and expansion of trisomy 7 in a fibroblast strain from a centenarian individual☆

1999 • 7 citations