Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

c-MYC: more than just a matter of life and death

2002 • 1,147 citations

Rules for Making Human Tumor Cells

2002 • 928 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

Myc activates telomerase

1998 • 650 citations

Cancer and ageing: rival demons?

2003 • 498 citations

Telomeres, stem cells, senescence, and cancer

2004 • 480 citations

Myc pathways provoking cell suicide and cancer

2003 • 461 citations

Beginning to Understand the End of the Chromosome

2004 • 416 citations

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

1999 • 404 citations

Telomerase: A target for cancer therapeutics

2002 • 331 citations

Taking the Study of Cancer Cell Survival to a New Dimension

2002 • 302 citations

Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation

2003 • 250 citations

Transformation of normal human cells in the absence of telomerase activation

2002 • 154 citations

Derivation of human tumor cells in vitro without widespread genomic instability.

2001 • 126 citations

Myc

2004 • 109 citations

Mammalian telomeres and telomerase: why they matter for cancer and aging

2003 • 104 citations

Immortalization and Transformation of Human Cells

2002 • 84 citations

Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karyotyping to the analysis of glioblastoma multiforme

2004 • 58 citations

Characterization of the 1p/19q Chromosomal Loss in Oligodendrogliomas Using Comparative Genomic Hybridization Arrays (CGHa)

2004 • 52 citations

Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts

2004 • 51 citations

High-Resolution Analysis of Genetic Events in Cancer Cells Using Bacterial Artificial Chromosome Arrays and Comparative Genome Hybridization

2003 • 49 citations

Telomerase immortalization of human neural progenitor cells

2004 • 31 citations

Immortalization of human osteoblasts by transferring human telomerase reverse transcriptase gene

2004 • 28 citations

Cell Immortality and Hallmarks of Cancer

2003 • 25 citations

Immortalization and characterization of human myometrial cells from term-pregnant patients using a telomerase expression vector

2004 • 24 citations

Application of spectral karyotyping to the analysis of the human chromosome complement of interspecies somatic cell hybrids

2003 • 21 citations

Rapid localization of transgenes in mouse chromosomes with a combined Spectral Karyotyping/FISH technique

2002 • 18 citations