Neonatal Hepatitis Induced by α ₁ -Antitrypsin: a Transgenic Mouse Model

Liver Disease in Alpha₁-Antitrypsin Deficiency Detected by Screening of 200,000 Infants

1976 • 787 citations

Heterozygous MZ Alpha1-Antitrypsin Deficiency in Adults with Chronic Active Hepatitis and Cryptogenic Cirrhosis

1981 • 200 citations

The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes.

1987 • 196 citations

Amino acid substitution Glu→Lys in α₁‐antitrypsin PiZ

1976 • 180 citations

Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency.

1976 • 172 citations

Multiple tissues express alpha 1-antitrypsin in transgenic mice and man.

1988 • 153 citations

Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice.

1987 • 126 citations

Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice

1987 • 117 citations

The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA.

1985 • 99 citations

The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice

1987 • 56 citations

Detection of Pi Z phenotype individuals by alpha-1-antitrypsin (AAT) immunohistochemistry in paraffin-embedded liver tissue specimens

1986 • 33 citations

Human α₁ ‐antitrypsin expression in Xenopus oocytes

1985 • 10 citations