Activation of ras oncogene in aflatoxin-induced rat liver carcinogenesis.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

1976 • 850 citations

RNA tumor viruses

1982 • 833 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 • 736 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

1980 • 387 citations

Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat.

1967 • 352 citations

Dietary aflatoxins and liver cancer – a population based study in Kenya

1973 • 304 citations

Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.

1977 • 252 citations

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse.

1986 • 250 citations

Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver.

1978 • 246 citations

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

1986 • 235 citations

Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse.

1986 • 177 citations

Aflatoxin B-oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes guanine substitution in nucleic acids

1977 • 172 citations

A Case-Control Dietary Study of Primary Liver Cancer Risk from Aflatoxin Exposure*

1982 • 167 citations

Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors.

1987 • 135 citations

Oncogenes and human cancer: cause or consequence?

1986 • 127 citations

Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene

1983 • 97 citations

Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1.

1986 • 97 citations

A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-rasoncogene

1986 • 93 citations

Carcinogenesis in rats by aflatoxins B1, G1, and B2.

1969 • 90 citations

Multifactoral etiology of human liver cancer

1984 • 86 citations

Activation of N-ras in a Human Melanoma Cell Line

1985 • 80 citations

Highly repeated DNA families in the rat.

1984 • 74 citations

Molecular cloning of an oncogene from a human hepatocellular carcinoma.

1986 • 71 citations

An examination of the relative resistances to aflatoxin B¹ and susceptibilities to γ-glutamyl p-phenylene diamine mustard of γ-glutamyl transferase negative and positive cell lines

1981 • 60 citations

Comparison of aflatoxin B1 and aflatoxin G1 binding to cellular macromolecules in vitro, in vivo and after peracid oxidation; characterisation of the major nucleic acid adducts

1979 • 55 citations

Carcinogen specificity in the activation of transforming genes by direct-acting alkylating agents

1985 • 44 citations

gamma-Glutamyltranspeptidase and the ras-induced transformation of a rat liver cell line.

1986 • 33 citations

Effect of formation and removal of aflatoxin B1:DNA adducts in 10T 1/2 mouse embryo fibroblasts on cell viability.

1980 • 25 citations

An alternative assay system for the detection of transforming genes

1984 • 7 citations

Identification of human N-ras as the common oncogene in NIH 3T3 cells transformed with DNAs from human primary hepatic cancer and hepatoma 7402 line.

1986 • 5 citations

A system for transformation of rat liver cells in vitro by acute treatment with aflatoxin

1987 • 4 citations