Response of aged mice to primary virus infections

Prevention and Control of Influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP)

2001 • 4,817 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

„Natural”︁ killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell

1975 • 1,090 citations

Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong

2003 • 978 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

Coordinated and Distinct Roles for IFN-αβ, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection

2002 • 594 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.

1981 • 345 citations

Herpes Zoster in Older Adults

2001 • 318 citations

Respiratory Syncytial Virus Pneumonia among the Elderly: An Assessment of Disease Burden

1999 • 296 citations

Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly

2002 • 241 citations

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

2001 • 195 citations

Decline in mitogen induced proliferation of lymphocytes with increasing age.

1987 • 192 citations

Effect of Age on Cytotoxic T Lymphocyte Memory as well as Serum and Local Antibody Responses Elicited by Inactivated Influenza Virus Vaccine

1993 • 189 citations

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

1995 • 179 citations

Influenza: Its Control in Persons and Populations

1986 • 177 citations

Biology and Pathogenesis of Lymphocytic Choriomeningitis Virus Infection

2002 • 172 citations

Age-related changes in Type 1 and Type 2 cytokine production in humans.

2002 • 164 citations

Specific Humoral Immunity in the Elderly: in vivo and in vitro Response to Vaccination

1993 • 159 citations

Age‐related changes in lymphokine production related to a decreased number of CD45RB^hi CD4⁺ T cells

1991 • 154 citations

T cell–dependent production of IFN-γ by NK cells in response to influenza A virus

2004 • 151 citations

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

2002 • 140 citations

Depression of cell-mediated immunity in old age and the immunopathic diseases, lupus erythematosus, chronic hepatitis and rheumatoid arthritis.

1973 • 124 citations

Defective generation but normal maintenance of memory T cells in old mice

2002 • 122 citations

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

2003 • 118 citations

Herpes Simplex Virus Type 2 Virion Host Shutoff Protein Regulates Alpha/Beta Interferon but Not Adaptive Immune Responses during Primary Infection In Vivo

2003 • 116 citations

Influenza in senescent mice: impaired cytotoxic T-lymphocyte activity is correlated with prolonged infection.

1991 • 111 citations

The immune response of aged mice to influenza: Diminished T-cell proliferation, interleukin 2 production and cytotoxicity

1983 • 106 citations

Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells

2002 • 93 citations

Systemic and local antibody responses in elderly subjects given live or inactivated influenza A virus vaccines

1989 • 83 citations

Respiratory viral infections in the elderly

1999 • 81 citations

Innate Immune Responses to LCMV Infections: Natural Killer Cells and Cytokines

2002 • 74 citations

Interleukin-10 Production by Splenic CD4+ Cells and Cell Subsets from Young and Old Mice

1994 • 71 citations

Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium lonophore A23187-stimulated T cells from elderly humans

1989 • 69 citations

Hemagglutinin-specific cytotoxic T-cell response during influenza infection.

1977 • 66 citations

INFLUENZA

2000 • 59 citations

Diminished T-cell response to influenza virus in aged mice.

1983 • 57 citations

T Cell Responses to Viral Infections: Lessons from Lymphocytic Choriomeningitis Virus

2002 • 56 citations

Passive serum antibody causes temporary recovery from influenza virus infection of the nose, trachea and lung of nude mice.

1988 • 56 citations

Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples

1996 • 51 citations

Pulmonary immune response of young and aged mice after influenza challenge.

1995 • 47 citations

Heterotypic Immune Mice Lose Protection against Influenza Virus Infection with Senescence

1993 • 44 citations

Variations in Activity of the Human Natural Anti-Gal Antibody in Young and Elderly Populations

1995 • 43 citations

Important infections in elderly persons.

1981 • 42 citations

Depletion of T Cells by Type I Interferon: Differences between Young and Aged Mice

2005 • 40 citations

Soluble Interleukin 2 Receptors Released from Mitogen Stimulated Human Peripheral Blood Lymphocytes Bind Interleukin 2 and Inhibit IL2 Dependent Cell Proliferation

1989 • 36 citations

Clinical significance of serum hepatitis C virus titers in patients with chronic type C hepatitis.

1996 • 35 citations

Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection

2003 • 31 citations

Age-related changes in interferon-α/β receptor expression, binding, and induction of apoptosis in natural killer cells from C57BL/6 mice

2000 • 25 citations

Basal Natural Killer Cell Activity of Young versus Elderly Humans

1995 • 24 citations

Influenza A/Brazil/78(H1N1) infection in the elderly.

1981 • 24 citations

Cellular immune responses to influenza.

2003 • 20 citations

In Vivo generation of antigenic variants of murine retroviruses

1989 • 19 citations

Decreased IL-2, IFN-γ, and IL-10 Production by Aged Mice During the Acute Phase of E55+ Retrovirus Infection

2002 • 17 citations

Genetic differences in the age-associated decrease in inducibility of natural killer cells by interferon-α/β

2000 • 16 citations

Friend virus replication as a function of age

1987 • 15 citations

Effect of Age on Viral Infections: Possible Role of Interferon

1987 • 15 citations

Diminished T cell surveillance function in old mice infected with lymphocyte choriomeningitis virus.

1977 • 15 citations

Evidence for age-dependent impairment of antiviral 2′,5′-oligoadenylate synthetase/ribonuclease l-system in tissues of rat

1993 • 14 citations

Effect of Non-H-2-linked Genes on Anti-virus Immune Responses and Long-Term Survival in Mice Persistently Infected with E-55+ Murine Leukemia Virus

1995 • 14 citations

Prolonged E55+ Retrovirus Expression in Aged Mice Is Associated with a Decline in the Anti-Virus Immune Response

2001 • 11 citations

Differences in the Immune Response During the Acute Phase of E-55+ Murine Leukemia Virus Infection in Progressor BALB and Long Term Nonprogressor C57BL Mice

1998 • 11 citations

Murine Leukemia Virus Infection in Immunocompetent Adult Mice

1993 • 10 citations

T cell–dependent production of IFN-γ by NK cells in response to influenza A virus

2004 • 9 citations