Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Type I Interferon-mediated Stimulation of T Cells by CpG DNA

1998 • 361 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells

2000 • 355 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Thymic aging and T‐cell regeneration

1997 • 244 citations

Antigen-independent changes in naive CD4 T cells with aging.

1996 • 240 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

Restoration of T-cell homeostasis after T-cell depletion

1997 • 218 citations

Interleukin-2, Interleukin-15, and Their Receptors

1998 • 198 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

1999 • 175 citations

Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

1997 • 157 citations

Age‐related changes in lymphokine production related to a decreased number of CD45RB^hi CD4⁺ T cells

1991 • 154 citations

Early activation defects in T lymphocytes from aged mice

1997 • 148 citations

Aging and T-cell-mediated immunity

1999 • 146 citations

Lifespans of naive, memory and effector lymphocytes

1993 • 133 citations

Lymphocyte homeostasis

1997 • 133 citations

Upregulation of surface markers on dying thymocytes.

1995 • 122 citations

From naive to effector ‐ alterations with aging

1997 • 118 citations

Aging and the immune system

1997 • 109 citations

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.

1996 • 84 citations

Age Differences in Eicosanoid Production of Mouse Splenocytes: Effects on Mitogen-induced T-cell Proliferation

1994 • 84 citations

The Growth of the Very Large CD8+ T Cell Clones in Older Mice Is Controlled by Cytokines

2001 • 81 citations

Prostaglandin E2 inhibits human T-cell proliferation after crosslinking of the CD3-Ti complex by directly affecting T cells at an early step of the activation process

1987 • 70 citations

Accessory Function and Properties of Monocytes from Healthy Elderly Humans for T Lymphocyte Responses to Mitogen and Antigen

1993 • 51 citations

G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4⁺ cells of older lupus mice

1997 • 44 citations

Macrophage-induced T cell mitogen suppression with age.

1980 • 43 citations

Lymphoblastoid Interferon-α Inhibits T Cell Proliferation and Expression of Eosinophil-Activating Cytokines

1996 • 41 citations

Molecular Determinants of Insulin Action

1993 • 38 citations

Increased production of TGF-beta and Il-6 by aged spleen cells

1993 • 35 citations

Macrophages suppress lectin-induced proliferation of lymphocytes from aged rats

1993 • 31 citations