Biology and Pathogenesis of Lymphocytic Choriomeningitis Virus Infection

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Identification of α-Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus

1998 • 675 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTION

1969 • 345 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I Expression

1991 • 308 citations

Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression

1995 • 289 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells

2000 • 283 citations

Dystroglycan inside and out

1999 • 282 citations

Concepts in Viral Pathogenesis

1984 • 272 citations

Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease

1972 • 262 citations

HLA-A11 Epitope Loss Isolates of Epstein-Barr Virus From a Highly A11 ⁺ Population

1993 • 255 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

1994 • 243 citations

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

1991 • 231 citations

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

1994 • 226 citations

Effect of oncogenic virus on muscle differentiation.

1975 • 182 citations

Virus-Induced Alterations in Homeostasis: Alteration in Differentiated Functions of Infected Cells in Vivo

1982 • 182 citations

H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.

1976 • 173 citations

STUDIES ON CELL-MEDIATED IMMUNITY TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN MICE

1973 • 167 citations

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.

1988 • 166 citations

PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTION

1970 • 163 citations

Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection

1998 • 159 citations

Differences in Affinity of Binding of Lymphocytic Choriomeningitis Virus Strains to the Cellular Receptor α-Dystroglycan Correlate with Viral Tropism and Disease Kinetics

2001 • 158 citations

Molecular anatomy of viral persistence

1991 • 148 citations

Organ-specific selection of viral variants during chronic infection.

1988 • 148 citations

Progress in Medical Virology

1968 • 147 citations

Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte

1999 • 146 citations

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

1995 • 145 citations

PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY

1936 • 144 citations

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus

1986 • 138 citations

IMMUNOPATHOGENESIS OF ACUTE CENTRAL NERVOUS SYSTEM DISEASE PRODUCED BY LYMPHOCYTIC CHORIOMENINGITIS VIRUS

1972 • 134 citations

TOGA: An automated parsing technology for analyzing expression of nearly all genes

2000 • 133 citations

Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production.

1984 • 131 citations

Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection

1989 • 127 citations

Alterations of acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus

1977 • 126 citations

Ueber die Mosaikkrankheit der Tabakspflanze

1892 • 125 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.

1990 • 119 citations

Virus-lymphocyte interactions IV. Molecular characterization of LCMV Armstrong (CTL+) small genomic segment and that of its variant, clone 13 (CTL−)

1988 • 118 citations

Viral perturbation of endocrine function: disordered cell function leads to disturbed homeostasis and disease

1984 • 116 citations

IMMUNOPATHOGENESIS OF ACUTE CENTRAL NERVOUS SYSTEM DISEASE PRODUCED BY LYMPHOCYTIC CHORIOMENINGITIS VIRUS

1972 • 113 citations

Virus neutralization and virus-induced immune complex disease. Virus-antibody union resulting in immunoprotection or immunologic injury--two sides of the same coin.

1975 • 111 citations

Virus Persists in β Cells of Islets of Langerhans and Is Associated with Chemical Manifestations of Diabetes

1984 • 107 citations

H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Effector Functions in Vivo

1976 • 99 citations

Expression of differentiated functions in cancer cells

1982 • 95 citations

Detection of a high frequency of virus-specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus.

1998 • 95 citations

Virus-Induced Immunosuppression

1993 • 93 citations

In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection.

1989 • 93 citations

Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

1995 • 91 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

How Viruses Escape from Cytotoxic T Lymphocytes: Molecular Parameters and Players

1997 • 89 citations

Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment

1985 • 89 citations

The Immune Response to Viruses

1989 • 87 citations

In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.

1991 • 86 citations

Cutting Edge: Detection of a High Frequency of Virus-Specific CD4+ T Cells During Acute Infection with Lymphocytic Choriomeningitis Virus

1998 • 86 citations

LYMPHOCYTIC CHORIOMENINGITIS INFECTION OF MICE AS A MODEL FOR THE STUDY OF LATENT VIRUS INFECTION

1958 • 84 citations

CTL Escape Viral Variants

1995 • 83 citations

Molecular basis of organ-specific selection of viral variants during chronic infection

1991 • 83 citations

The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2

1985 • 80 citations

Immune therapy of a persistent and disseminated viral infection

1987 • 77 citations

The Genes for Color Vision

1989 • 77 citations

Recent clinical isolates of cytomegalovirus suppress human cytomegalovirus-specific human leukocyte antigen-restricted cytotoxic T-lymphocyte activity

1986 • 75 citations

Virus-lymphocyte interactions

1978 • 74 citations

Cytotoxic T Lymphocyte Control of Acute Lymphocytic Choriomeningitis Virus Infection: Interferon , but Not Tumour Necrosis Factor , Displays Antiviral Activity in vivo

1989 • 72 citations

Berichte der Kommission zur Erforschung der Maul- und Klauenseuche bei dem Institut für Infektionskrankheiten in Berlin

1898 • 66 citations

Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation

1992 • 64 citations

Perturbation of differentiated functions during viral infectionin Vivo I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency

1985 • 63 citations

Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virus

1990 • 63 citations

Virus-Induced Behavioral Alteration of Mice

1977 • 63 citations

Binding of Viral Antigens to Major Histocompatibility Complex Class I H-2Db Molecules Is Controlled by Dominant Negative Elements at Peptide Non-anchor Residues

1996 • 62 citations

Defining Parameters for Successful Immunocytotherapy of Persistent Viral Infection

2000 • 61 citations

A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome

1996 • 60 citations

Antiviral Action of Immune Lymphocytes in Mice Infected with Lymphocytic Choriomeningitis Virus

1972 • 60 citations

CTL Escape Viral Variants

1995 • 59 citations

Ultrastructural localization of viral antigens in the CNS of mice persistently infected with lymphocytic choriomeningitis virus (LCMV).

1983 • 59 citations

Viral Persistence in Neurons Alters Synaptic Plasticity and Cognitive Functions without Destruction of Brain Cells

1996 • 59 citations

Selective disruption of growth hormone transcription machinery by viral infection.

1992 • 58 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants.

1984 • 57 citations

Viral infection of neurons can depress neurotransmitter mRNA levels without histologic injury

1988 • 56 citations

Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains

1984 • 55 citations

Viral Alteration of Cell Function

1989 • 53 citations

Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus

1988 • 52 citations

Interaction between antigenically different cells. Virus-induced cytotoxicity by immune lymphoid cells in vitro.

1969 • 51 citations

Competitive selection in vivo by a cell for one variant over another: implications for RNA virus quasispecies in vivo

1996 • 50 citations

Suppression of Lymphocytic Choriomeningitis Virus—Induced Growth Hormone Deficiency Syndrome by Disease-Negative Virus Variants

1996 • 48 citations

Abrogation of tolerance to a chronic viral infection.

1991 • 47 citations

Cytotoxic T Lymphocytes Cleanse Viral Gene Products from Individually Infected Neurons and Lymphocytes in Mice Persistently Infected with Lymphocytic Choriomeningitis Virus

1993 • 46 citations

Vaccination to Treat Persistent Viral Infection

2000 • 44 citations

Effect of chronic viral infection on the immune system. I. Comparison of the immune responsiveness of mice chronically infected with LCM virus with that of noninfected mice.

1973 • 44 citations

MANUSCRIPT PREPARATION

1975 • 42 citations

Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence

1994 • 41 citations

Neurotransmitter abnormalities in Borna disease

1988 • 40 citations

Progress in Medical Virology

1974 • 39 citations

Virus Can Alter Cell Function Without Causing Cell Pathology: Disordered Function Leads to Imbalance of Homeostasis and Disease

1984 • 37 citations

Infection with Cytotoxic T-Lymphocyte Escape Mutants Results in Increased Mortality and Growth Retardation in Mice Infected with a Neurotropic Coronavirus

1998 • 36 citations

Behavioral effects of persistent lymphocytic choriomeningitis virus infection in mice

1994 • 35 citations

Lymphocytic choriomeningitis virus selectively alters differentiated but not housekeeping functions: Block in expression of growth hormone gene is at the level of transcriptional initiation

1989 • 31 citations

Pathology of the choroid plexus in spontaneous immune complex disease and chronic viral infections

1974 • 31 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus and in vitro properties

1985 • 29 citations

Perturbation of differentiated functions in Vivo during persistent viral infection III. Decreased growth hormone mRNA

1987 • 29 citations

DISEASE ACCOMPANYING IN UTERO VIRAL INFECTION

1972 • 28 citations

Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus.

1983 • 26 citations

Tissue-mediated selection of viral variants: correlation between glycoprotein mutation and growth in neuronal cells

1994 • 23 citations

Variants able to cause growth hormone deficiency syndrome are present within the disease-nil WE strain of lymphocytic choriomeningitis virus

1996 • 21 citations

Role of the major histocompatibility complex in targeting effector T cells into a site of virus infection

1986 • 19 citations

Cloning and expression analyses of mouse dystroglycan gene: specific expression in maternal decidua at the peri-implantation stage

1996 • 19 citations

Rous-Whipple Award Lecture. Viruses and diseases of the twenty-first century.

1993 • 19 citations

Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons

1993 • 18 citations

The pathogenesis of cellular injury associated with persistent lcm viral infection. Abstr.

1969 • 17 citations

Role of Viral Strains and Host Genes in Determining Levels of Immune Complexes in a Model System: Implications for HIV Infection

1991 • 16 citations

Dissecting the molecular anatomy of the nervous system: Analysis of RNA and protein expression in whole body sections of laboratory animals

1986 • 15 citations

Disruption of Differentiated Functions during Viral Infection in Vivo

2001 • 14 citations

Persistent infection with lymphocytic choriomeningitis virus enhances expression of MHC class I glycoprotein on cultured mouse brain endothelial cells.

1991 • 12 citations

Molecular anatomy of viral disease

1987 • 12 citations

An Old Nemesis in New Clothing: Viruses Playing New Tricks by Causing Cytopathology in the Absence of Cytolysis

1985 • 12 citations

Treatment with anti-tumor necrosis factor α does not influence the immune pathological response against lymphocytic choriomeningitis virus

1990 • 11 citations

Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency.

1990 • 11 citations